Online ISSN: 2515-8260

Keywords : Serum osteoprotegerin

Physiological and biochemical markers of arterial stiffness fluctuate with age in apparently healthy people

Anzarul Hasan, Surendra Prasad Singh

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 10085-10092

Objectives: Arterial stiffness develops with age and is an independent risk factor for
cardiovascular disease. The brachial ankle pulse wave velocity (baPWV) and serum
osteoprotegerin (OPG) are two new physiological and biochemical measures used to
assess arterial stiffness. We looked at how age affects physiological and biochemical
measures of arterial stiffness.
Materials and methods: It were a cross-sectional, observational study on 118 apparently
healthy male and 114 female patients aged 30–>60 years who did not have any
cardiovascular or peripheral vascular disease and were not on any antihypertensive or
lipid-lowering medication. The following parameters were measured: brachial systolic
blood pressure (bSBP), brachial diastolic blood pressure, central systolic blood pressure
(cSBP), central diastolic blood pressure (cDBP), heart rate, augmentation index
(AIx[percent]), and baPWV. The recorded data were used to calculate the mean arterial
pressure (MAP), pulse pressure (PP), and PP ratio (PPR). Serum samples were
analysed in order to determine the OPG level and lipid profile. The Kruskal–Wallis’s
test was used to compare the differences between the parameters.A Spearman
correlation analysis was used to see if there was any relationship between baPWV and
other parameters. To identify the factors linked with baPWV, multiple linear regression
analysis was used. P 0.05 was deemed statistically significant.
Results: Males had significantly larger height, weight, and PPR values than females.
Females exhibited considerably greater BMI, AIx (percentage), cSBP, cPP, and brachial
PP values than males. In comparison to younger boys, older males showed considerably
higher AIx (percent), cPP, and brachial PP. In compared to younger girls, older females
had considerably greater AIx (percent), cPP, brachial PP, serum cholesterol,
triglyceride (TG), low-density lipoprotein cholesterol (LDLc), and very LDLc (VLDLc).
Serum OPG levels were discovered to be a primary factor influencing baPWV values in
both males and females.Other cardiovascular measures such as cSBP, cDBP, cMAP,
brachial SBP, and MAP influenced baPWV values in both genders, while serum
cholesterol and LDLc influenced baPWV values in the male participants in the current
study. Serum TG and OPG levels were found to be highly linked with baPWV in both
genders, according to regression analysis