European Journal of Molecular & Clinical Medicine

AIM:To study the efficacy of steroid nasal spray alone and steroid nasal spray with oral steroids in patients of ethmoidal polyposis with chronic rhinosinusitis.
MATERIALS AND METHODS: All the patients with presentation of chronic sinusitis with ethmoidal polyposis, fitting in the definition of the study and fulfilling the inclusion criteria had a detailed history taking of the concerned complaints. Steroid therapy was given to each patient in the study for 6 weeks. One group of patients were given topical steroid in form of mometasone nasal spray for 6 weeks (Group A) and the other group was given mometasone nasal spray along with 8 mg of methylprednisolone for 15 days in a tapering dose (Group B). Each patient underwent a thorough radiological examination of the nose following steroid therapy.
RESULTS: The symptoms were significantly reduced in both of our research groups, but the most improvement was shown in those who had both systemic and local steroid therapy. The odds of improvement with topical steroid treatment only is 0.1905 times that of the odds of improvement with topical and systemic steroid treatment based on CT PNS in all individuals. The symptom and polyp size reduction rate was significantly greater in Group B individuals than in Group A (p value-0.01209) as evidenced on CT PNS.
CONCLUSION: In conclusion the results of this study indicate that thrice daily administration of 8 mg oral preparation of methylprednisolone for 15 days and topical steroid in the form of nasal spray for 6 weeks is an efficacious treatment for chronic rhinosinusitis with ethmoidal polyposis. It also provides significant relief of symptoms, reduction in polyp size and overall control of mucosal inflammation and tissue remodeling (p value- 0.012)

Background: Chronic rhinosinusitis (CRS) represents a common source of ill health, affecting 5%–12% of the general population. The present study was conducted to assess patients with chronic rhinosinusitis.
Materials & Methods: The present study was conducted to analyze patients with Chronic Rhinosinusitis. Medical records of 120 patients were reviewed with a clinical diagnosis of Chronic Rhinos sinusitis. Complete demographic records and complete history were recorded. The data was tabulated and subjected to statistically analysis. The statistical analysis of the data was done using SPSS version 20.0 for windows. The p-value less than 0.05 was predetermined as statistically significant.
Results: Medical records of 120 patients were reviewed with a clinical diagnosis of Chronic Rhinosinusitis. Maximum patients had history of reactive airway disease (25%) followed by history of tobacco exposure (18.33%). 33.33% patients had rhinorrhea the most common symptom followed by congestion (26.66%). The results on comparison were observed to be statistically non-significant (p>0.05).
Conclusion: The present study concluded that the most common symptom experienced by patients was rhinorrhea and maximum patients had past medical history of reactive airway disease.

Background:Chronic rhinosinusitis (CRS) affects approximately millions of individuals
every year. It is characterized by inflammation of nose and paranasal sinuses, thus
becoming one of the most common disorders of the upper airway. The present study was
conducted to assess cases of chronic sinonasal diseases & nasal polyposis using functional
endoscopic sinus surgery.
Materials & Methods: 72 patients of chronic sinonasal diseases & nasal polyposis of both
genders were assessed radiologically as well as endoscopically. All patients underwent
functional endoscopic sinus surgery, using the Messerklinger’s approach. They were
recalled for 6 weeks.
Results: Out of 72 patients, males were 42 and females were 30. Endoscopic findings were
DNS in 34, middle turbinate hypertrophy in 18, inferior turbinate hypertrophy in 5,
enlargedaggernasi in 6, Mpd in middle meatus in 5 and edematous/polypoidal up in 4
cases. The difference was significant (P< 0.05). Clinical features were nasal discharge in
62, nasal obstruction in 48, sneezing in 57, headache in 61, post nasal drip in 35 and
epistaxis in 29. The difference was significant (P< 0.05).
Conclusion: Chronic rhinosinusitis is common among all people. Functional endoscopic
sinus surgery is useful in these patients.