European Journal of Molecular & Clinical Medicine

Background: COVID-19 pandemic originated in the city of Wuhan in Hubie province of China and within three months of its origin the disease extended to nearly 221 countries in the world.
Objective: The objective is Study of hematological and various biochemical Markers in COVID-19 patients admitted in a tertiary care centre .
Methodology: In this single-center study, records of 170  patients hospitalized with COVID-19 were studied for hematological profile and biochemical markers. Records of patients with laboratory-confirmed COVID-19 disease hospitalized between April  2020, to August  2020, were included in the analysis.
Result: A total of 170  patients were enrolled of Age Group  20-80 year of which 80% (136/170) were asymptomatic and 20% (34/170) symptomatic. 17% patients had co-existing illnesses. Clinical spectrum among COVID-19 patients varied from being asymptomatic to having symptoms like fever, dry cough, breathlessness with few progressing to respiratory failure and multi-organ failure. In our study, 96.0% (163/170) recovered while 4.0% (7/170) died. Mean age, total leucocyte count (TLC), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and lactate dehydrogenase (LDH) ,Procalcitonin, CRP, D dimer of severely ill patients were significantly higher than those of patients with non-severe illness.
Conclusion: The clinicians may consider the hematological and biochemical parameters in the patients with COVID-19 in future decision-making.  Elevated NLR, TLC, LDH, C-Reactive Protein, Procalcitonin, D dimer and lymphopenia were seen in the symptomatic patients especially manifesting severe disease. Early intervention and periodic monitoring of these parameters in patients, especially with severe disease may help in improving disease outcome

Low plasma homocysteine (Hyc) level during an uncomplicated pregnancy was first demonstrated by Kang et al. almost 20 yrs ago, & this has subsequently been confirmed by numerous investigators. Plasma homocysteine concentrations are 30-60% lower in pregnant women than in non-pregnant women & the lowest levels are observed in the second trimester.
The study was a hospital based prospective study & carried out in the setting of department of Pathology & department of Obstetrics and Gynae, N.S.C.B Medical College over 100 Females. Homocysteine Tests are conducted at Path Care Labs. The cases with Pre-eclampsia have higher probabilities of having raised Hcy by 1.92% more compared with Non Pre-eclamptic cases and 0.21 at the worst being the Upper and Lower limits of 95% confidence intervals for Odds Ratio (OR=0.66). As per our study the Hcy levels were much raised in patients who were not taking Fe/Folate supplements (50.9%) as compared to those taking Fe/Folate supplement (4.3%) & this difference is highly significant indicating that Folate supplements help in keeping Hcy levels normal.