European Journal of Molecular & Clinical Medicine

Background: The spontaneous pregnancy loss for a women can be physically and emotionally taxing. Spontaneous abortion is the term given to a miscarriage or termination of a pregnancy that takes place before the twentieth week of gestation on its own. Pregnancies that end in a natural abortion within the first trimester are the only ones that can be referred to as having a "early pregnancy loss." Pregnancies that have a prior history of spontaneous abortions ought to be regarded as high-risk pregnancies, and additional precautions ought to be taken during the ante-natal period in preparation for these outcomes. The goal of this study is to look into the outcomes of pregnancies among women who had a history of spontaneous abortions in previous pregnancies.
Methods: In the department of Obstetrics and Gynecology, Dr. D.Y. Patil Medical College, Hospital, and Research Centre in Pune, a prospective and comparative research was conducted. The sample size for the study was 400, with study group of 200 cases and control group of 200 cases.
Patients with history of spontaneous abortion in previous pregnancy, irrespective of cause and period of gestation were included in study population. For control group, patients with history of previous term delivery, irrespective of mode of delivery were included
Results: In threatened abortions, we observe that 20 (10%) patients had symptoms of threatened abortions while 13 (6.50%) patients had threatened abortions in control group. There are more number of cases of threatened abortion in previous abortion cases when compared to previous normal delivery.

Low plasma homocysteine (Hyc) level during an uncomplicated pregnancy was first demonstrated by Kang et al. almost 20 yrs ago, & this has subsequently been confirmed by numerous investigators. Plasma homocysteine concentrations are 30-60% lower in pregnant women than in non-pregnant women & the lowest levels are observed in the second trimester.
The study was a hospital based prospective study & carried out in the setting of department of Pathology & department of Obstetrics and Gynae, N.S.C.B Medical College over 100 Females. Homocysteine Tests are conducted at Path Care Labs. The cases with Pre-eclampsia have higher probabilities of having raised Hcy by 1.92% more compared with Non Pre-eclamptic cases and 0.21 at the worst being the Upper and Lower limits of 95% confidence intervals for Odds Ratio (OR=0.66). As per our study the Hcy levels were much raised in patients who were not taking Fe/Folate supplements (50.9%) as compared to those taking Fe/Folate supplement (4.3%) & this difference is highly significant indicating that Folate supplements help in keeping Hcy levels normal.