European Journal of Molecular & Clinical Medicine

Enlarged prostate is one of the most common urinary tract illness encountered in elderly males. Prostate volume is a well-established single most important predictor for management of patients with prostatomegaly, presenting with lower urinary tract symptoms. The aim of this study is to find a correlation between IPSS, PSA and prostate volume measured by transrectal ultrasound and its impact on patient management. A total of 120 men >40 years of age with lower urinary tract symptoms underwent transrectal ultrasound for the estimation of prostate volume after the laboratory investigation for prostate specific antigen levels in blood and response to clinical questionnaire for International Prostate Symptoms Score. The prostate ranged from 10 cc to 130 cc, mean being 37.04 cc +18.81. As per grading by IPSS, 52 patients (43.3%) had severe symptoms, followed by moderate symptoms in 44 patients (36.6%) and only 24 patients (20%) were having mild symptoms. PSA values ranged from .04 to 19.5 ng /ml. with a mean value of  4.2 + 1.89 ng / ml. Significant correlation is found between prostate volume, IPSS and PSA with moderate but statistically significant correlation between IPSS and PSA. Thus, combined parameters of prostate volume, IPSS and PSA could serve as an eminent tool for making clinical decisions and surgical management of patients with lower urinary tract symptoms due to enlarged prostate

Background: Benign prostatic hyperplasia (BPH) is highly prevalent in elderly men and often results in lower urinary tract symptoms (LUTS). The present study was conducted to compare the efficacy of tadalafil with tamsulosin in the treatment of lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH).
Materials & Methods: 78 patients of diagnosed with LUTS secondary toBPHwere divided into 2 groups. Group I were given tadalafil 5 mg and group II tamsulosin 0.4 mg. Maximum flow rate (Qmax), Postvoid residual urine (PVR), International Prostate Symptom Score (IPSS), International Prostate Symptom Score Quality of life (IPSS QoL) and Sexual Health Inventory for Men (SHIM) scoring were compared.
Results: mean prostate size in group I was 32.5 gram and in group II was 30.1 gram. Qmax was 13.6 ml/sec in group I and 12.8 ml/sec in group II. PVR was 51.4 ml in group I and 83.2 ml in group II. IPSS was 12.7 in group I and 14.9 in group II, IPSS QoL was 2.3 in group I and 3.0 in group II. The difference was significant (P< 0.05).
Conclusion: Once daily tadalafil 5 mg is well tolerated and can be considered for the treatment of LUTS secondary to BPH when associated with ED

Objective: To examine the potential clinical implications of the voiding position in asymptomatic Indian men.
Materials and methods: Men between the ages of 20 and 70 were included in our prospective research of men. The subjects were required to complete a 3-day voiding diary, and uroflowmetry was performed in accordance with our department's normal methodology.
Results: Qavg and Qmax were 17.5 and 28.7 mL/s on average. The typical V24 and F24 were respectively 1653.7 mL and 6.5. The biggest single voided volume (r = 0.308, P = 0.002), the smallest single voided volume (r = 0.500, P = 0.001), the daytime voided volume (r = 0.378, P = 0.001), the nighttime voided volume (r = 0.533, P = 0.001), and Vavg (r = 0.704, P = 0.001) were all positively correlated with the mean V24. PVR (r = 0.415, P<0.001), night time frequency (r = 0.353, P<0.001), and voiding frequency (r = 0.345, P < 0.001) were all strongly correlated with mean age.
Conclusion: The uroflowmetry parameters of elderly men are significantly influenced by the voiding position. It was discovered that voiding while sitting was ideal for elderly men, but it was impossible to tell what effect the voiding position had in healthy young men. To further understand this problem, more investigation is required.