Keywords : GABA
Clinical Depression; Are Biochemicals the Culprit Behind?
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 3, Pages 11674-11692
Background:Depression is a medical condition, illness of the brain in which an individual is conquered by the feeling of sadness, hopelessness, guilt and so on. Depression is one of the commonest human blight, mental illness causing more ‘years lost to disability’ (YLD) than any other illness and the sufferer learns to live with it, adapts it both mentally and physically. WHO fact sheets states that depression affects nearly 350 million people; yet, difficult to recognise initially, then diagnose and ultimately treat. Since the disease creates disinterest in day-to-day activities, it also affects dietary pattern of the person, leading to inadequate, imbalanced diet essential for maintaining mental health. B Complex vitamins; pyridoxal phosphate, folate and cobalamin plays an important role in maintaining good physical and mental health as these act as co-enzymes and co-factors in metabolic processes. Biosynthesis of GABA, the inhibitory neurotransmitter of the brain requires PLP. Aim and Objective: Estimateserum levels of vitamin B6, B9, B12along with GABA, TSH and total cholesterol in controls and the cases. To evaluate the association of study biochemical variables with disease severity.
Materials and Methods: Present study is an experimental case control study performedon 204 people (102 controls and 102 patients) including both males and females between 18-65 years of age. Participants demoFigureic factors were recorded and biochemical variables were assayed. Hamilton Depression Rating Scale-17 items(HDRS) was used to rate the severity of depression.
Results: Most patients 47.1% enrolled in the study had mild form of depression. Females, married individuals, less educated and those belonging to middle income group of individuals of the study were more depressed. Serum levels of vitamin B6, B9, B12 were much lower in depressed subjects. Whereas, GABA levels were elevated in depressive patients.
Conclusion: Findings of the resultant study shows low levels of pyridoxal phosphate, folate, cobalamin and total cholesterol and higher GABA levels in newly diagnosed depression patients.