Online ISSN: 2515-8260
Keywords : WHO/ISUP grading
EXPRESSION OF P53 IN UROTHELIAL CARCINOMA AND ITS CORRELATION WITH THE GRADE OF THE TUMOR – A TWO YEARS STUDY IN A TERTIARY HOSPITAL
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 4, Pages 439-451
BACKGROUND
In India Urothelial carcinoma of bladder constitutes about 7% of all male cancers. It is associated with high morbidity and mortality.Current grading system in application by WHO/ISUP divides Urothelial malignancies as low and high grade tumors by morphological criteria. Grading Urothelial carcinomas depending on morphological criteria alone is some times difficult in limited tissue. In such cases tumor grading by alternative methods like IHC expression is useful. In the present study we have evaluated the diagnostic utility of p53 in grading Urothelial carcinomas.
MATERIALS AND METHODS :
The present study is an observational study conducted at department of Pathology, Gandhi Medical College/Hospital, Secunderabad for over a period of two years from June 2016 to May 2018. A total of 30 TURBT and Cystectomy specimens diagnosed as Urothelial carcinoma on routine H&E were included in the study. These tissues were later subjected to IHC markers for p53. The slides are reviewed and expression of these markers was evaluated and correlated with grade. The results were statistically analyzed.