Online ISSN: 2515-8260

Keywords : Hyperbaric 0.5% Bupivacaine

A comparative study of intrathecal bupivacaine 0.5% heavy with fentanyl versus intrathecal bupivacaine 0.5% heavy with buprenorphine in lower limb and lower abdominal surgeries

Dr. Mrunalini Alugolu, Dr.Padmavathi Bodiga, Dr. Pratiksha Chitta, Dr Praveena Thaduri

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 2342-2352

Aims: The aim of the study is to compare the anaesthetic efficacy of intrathecal
hyperbaric 0.5% Bupivacaine with 25mcg Fentanyl and intrathecal hyperbaric 0.5%
Bupivacaine with 60mcg Buprenorphine for lower abdominal and lower limb surgeries
Materials and methods: The present study was undertaken in Sixty patients (of either
sex belonging to ASA I and II physical status) posted for elective lower abdominal and
lower limb surgeries (under Spinal Anesthesia) were selected and were randomly
allocated into two groups; Buprenorphine (Group B), and Fentanyl (Group F).
Results: The demographic profile with regard to age ,gender, ASA grading, average
duration of surgery were comparable in all the groups. The onset of block , mean time
for onset of motor blockade,mean time for sensory regression, mean time for regression
to bromage ‘1’ , mean duration of analgesia was the difference between the groups was
statistically significant.Intraoperative heart rates were comparable among the two
groups (p<0.005). isolated incidents of Bradycardia were noticed – but were neither
statistically significant nor clinically significant. There was gradual fall in the SBP and
DBP towards 30 minutes into surgery followed by a stable state .Both the groups were
comparable (p>0.05) with regard to their MAP, although hypotension was noticed in
both the categories of patients.All the adverse events were mild in nature which
required no intervention. No episodes of respiratory depression, dry mouth, PDPH were
noted in any of the subject in both the groups.
Conclusions: Intrathecal Buprenorphine (60mcg) is superior over intrathecal Fentanyl
(25mcg) as an adjuvant to Intrathecal hyperbaric 0.5% Bupivacaine when prolongation
of spinal anaesthesia is desired.