Online ISSN: 2515-8260

Keywords : leukopenia


ASSESSMENT OF RISK FACTORS FOR ENTERIC PERFORATION IN CASES OF TYPHOID FEVER PATIENTS OF WEST ZONE OF RAJASTHAN

Dr. Manish Jakhar, Dr. Manoj Mali

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 6, Pages 1049-1052

Background:
The present study was conducted to assess risk factors for enteric perforation in cases of typhoid fever.
Materials & Methods: 58 cases of typhoid fever of both genders were included. Group I had typhoid fever patients having enteric perforation and group II had typhoid fever patients with no enteric perforation. Symptoms, signs and laboratory findings were recorded.
Results: Out of 58 patients, males were 32 and females were 26. Symptoms were diarrhea seen in 65% and 34%, vomiting in 70% and 52%, abdominal pain in 86% and 47%, constipation in 38% and 13% in group I and group II respectively. Signs were high fever (>38.3°C) in 94% and 90%, abdominal distention in 45% and 32%, hepatosplenomegaly in 86% and 36%, abdominal rigidity in 50%, confusion in 52% and rebound tenderness in 100%. Laboratory findings were anemia        in 15% and 12%, leukopenia in 54% and 22%, gas under diaphragm was 75%, thrombocytopenia in 65% and 22% and elevated transaminase in 58% and 43% respectively. The difference was significant (P< 0.05). Risk factors for enteric perforation was male gender, age >40 years and leukopenia (P< 0.05).
Conclusion: Authors found that risk factors for enteric perforation were male gender, age >40 years and leukopenia. Typhoid fever and its complications remain an important cause of morbidity in resource-poor countries.

STUDY OF CLINICAL OUTCOME IN ADULT PATIENTS WITH SEROLOGICALLY PROVEN DENGUE SYNDROME AT A TERTIARY HOSPITAL.

Panuganti Raveen, Panuganti Ratnachary, K. Sudharani

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 4, Pages 755-762

Background: Dengue fever is an acute febrile illness (AFI) caused by one or more dengue viruses belonging to genus Flavivirus and transmitted by Aedes aegypti mosquito. The exact clinical and laboratory profile is crucial for early diagnosis and management of patients. Present study was aimed to study clinical outcome in adult patients with serologically proven dengue syndrome at a tertiary hospital.
Material and Methods: Present study was hospital based, observational study, conducted in patients of age > 18 years, of either gender, with acute febrile illness, with serologically proven dengue syndrome admitted in wards & ICUs.
Results: We studied 210 serologically proven dengue patients in present study. Majority of patients were from 31-40 years age group (29.05%), were male (60.48%), NS 1 Positive (81.90%). In present study, non-severe dengue (83.81%) cases were more as compared to severe Dengue fever(DHF) (16.19%). Laboratory findings such as hematocrit < 36%, leukopenia, thrombocytopenia, reactive lymphocytes, prolonged PT, prolonged APPT, SGOT>40 IU/L & SGPT >40 IU/L were common in severe dengue group as compared to non-severe dengue group & difference was statistically significant (p