Online ISSN: 2515-8260

Keywords : Morphological Differentiation

Expression of P53 In Ovarian Tumors’ And Its Correlation To The Morphological Differentiation: Report From A Tertiary Care Hospital Of Bihar

Major Ragini Thapa,Col Ravikant Narain,Major Amit Rajan,Col Alok Sen, Suchismita

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 4, Pages 1431-1436

Ovarian tumors represent 3% of female malignancies, with over 140,000 worldwide annual associated deaths.Epithelial tumors constitute over 90% of all the ovarian cancers.This study aims to evaluate the expression of p53 by immunohistochemistry (IHC) in the different histological types and grades of epithelial ovarian tumors (EOT) and attempts to compare it with various Clinicopathological prognostic factors, namely, age, clinical presentation, stage, gross morphology, histopathology, grade, serum CA-125, etc.Materials and Methods: EOT specimens from 40 patients received in the Department of Pathology, Indira Gandhi Institute of Medical Science, Patna, Bihar, India from January 2021 to December 2021 were studied. Ethics committee permission was obtained, and ethical practices were followed. All specimens obtained were subjected to detailed gross and histopathological examinations.Results: Among the 40 cases of EOT, 24 (60%) were benign, 6 (15%) were borderline, and rest 10 (25%) were malignant. Serous malignancies were the largest group with followed by mucinous and clear cell carcinomas.Conclusion: Understanding of p53 staining patterns is mandatory to use it along with a panel of other antibodies for the correct classification and further research of morphologically confusing EOT