Online ISSN: 2515-8260

Keywords : Cardiac biomarkers


Dr Thomas mathew, Dr Manju M Haneefa

European Journal of Molecular & Clinical Medicine, 2023, Volume 10, Issue 1, Pages 4451-4456

Acute coronary syndrome (ACS) remains one of the leading causes of mortality worldwide. The prevalence of Coronary artery disease and the incidence of ACS are very high among Indians.
Objectives-The primary aim of this study was to assess the varying clinical presentation of patients with ACS and to determine the effectiveness of various treatment modalities establish an association between base line variable and ACS presentation.
Methods-A retrospective descriptive study was conducted in Department of Medicine (Cardiology) in MGM Muthoot Hospital, Kozhencherry for the period of One year. Medical records of patients admitted with ACS during the period of study. A total of 100 patients admitted with ACS through Non probability convenience sampling technique.
Results-There is significant association between outcome and Type-II diabetes mellitus.Since the p value is 0.048 is less than 0.05, there is significant association between outcome and Hypertension.Since the p value is 0.528 is greater than 0.05, there is no significant association between outcome and Dyslipidemia but no association with demographic profile. 2 the association between treatment modality and outcome is highly significant (p<0.05). PTCA was found to be most common treatment modalities done in more than 90% of patients.
Conclusion-The study reveals that from the Chi-square test analysis, it is found that there is no significant association between outcome and base line variables. But the significant association has been obtained between complications, Treatment modalities and outcome since the ‘p’ value is 0.000.Furthermore, studies with large sample size must be conducted for better accuracy of results with longer duration.

Evaluation of cardiac biomarkers in predicting severity of dengue fever

Dr. Chetan Kerur, Dr. Khizerulla Sharief, Dr. Mohana , Dr. Pragalatha Kumar

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 2508-2513

Dengue virus will affect several systems of the body. Myocardial involvement may be the direct effect of the virus itself or may be due to cytokine production. Myocarditis has a varied presentation, it may be clinical or subclinical. Myocarditis can present as cardiac failure, Electrocardiogram (ECG) changes (sinus bradycardia, sinus tachycardia, T wave inversion), 2 D Echocardiography changes (reduced ejection fraction) and elevated cardiac enzymes (Troponin T, CPK, CPK-MB, LDH, N terminal-BNP). The study was approved by the institutional ethical committee. Informed written consent was obtained from the parents of each patient before enrollment. History and examination findings were recorded in a pre-structured proforma. Children with clinically diagnosed dengue fever (WHO criteria) & serologically confirmed and admitted cases between the age group of 2months to 18 years formed the study group. In 110 biomarker positive cases, 32(17.3%) had a shock, 14 (7.6%) had bleeding manifestations, 78(42.2%) cases had elevated SGOT and SGPT and PT and aPTT elevated in 84(45.4%) and 44(23.8%) cases respectively.