European Journal of Molecular & Clinical Medicine

Background: The estimated prevalence of fatty liver in the general population averages around 14-25 % with rising prevalence in the presence of risk factors. Liver biopsy continues to be the ultimate and specific investigation for assessing the nature and severity of a spectrum of liver diseases. Present study was aimed to study clinical & histological profile of patients with nonalcoholic fatty liver disease.
Material and Methods: This study was retrospective and prospective, observational study, conducted in patients with increased echo texture of liver on routine ultra-sound scan, suggestive of fatty liver disease, prior to performing percutaneous liver biopsy, the proper preparation of a patient is important, with attention to a detailed knowledge of the procedure, a complete history and physical evaluation, medication use, and fresh clotting parameters.
Results: In present study, among 60 patients, 36 (60%) were females and 24(40%) were males. Majority were from the age group of 41- 50 years (36.66%), followed by 51-60 years (30 %).  Commonest symptom was fatigability and malaise (66.66%), followed by right upper abdominal discomfort (46.66%), Jaundice (10%), ascites (10%), UGI Bleed (8.3%) patients and 20 (33.33%) patients were asymptomatic at the time of diagnosis. The commonest clinical sign was of hepatomegaly or palpable liver (90%), edema (35 %), abdominal distension (18.33 %), splenomegaly (16.67 %) & icterus (13.33 %). Various risk factors noted were dyslipidemia (61.67 %), diabetes mellites (58.33 %), hypertension (53.33 %), overweight (50 %), obese (46.67 %) & coronary artery disease (40 %). 7 patients underwent biopsy. Of these 4.28% patient showed steatohepatitis, 42.86% patients showed simple fatty change and 14.28% patient had cirrhosis. Other 28.57% had no specific changes.
Conclusion: Our findings were consistent with the earlier concept that non-alcoholic steatohepatitis was prevalent in obese females with diabetes and hyperlipidemia.

Background: Non-alcoholic steatohepatitis is a clinicopathological syndrome, characterized by the development of histological features comparable to those induced by excessive alcohol intake without alcohol abuse. This study is an attempt to evaluate the clinical, biochemical and histological profile of non-alcoholic steatohepatitis in this tertiary hospital in Rayalasema.
Material and Methods: Present study was single-center, prospective, observational study, conducted in patients of all ages, either gender, who are found to have increased echo texture of liver on routine ultra-sound scan.
Results: The present study was conducted on 60 patients, comprised of 36(60%) males and 24(40%) females. Majority were from the age group of 41 to 50 years there were 22 (36.66%) cases of which 12 (54.54%) were males and 10 (45.46%) were females.  The commonest symptom was fatigability and malaise (66.66%), followed by right upper abdominal discomfort (46.66%), Jaundice (10%), ascites (10%), UGI Bleed (8.3%) patients and 20 (33.33%) patients were asymptomatic at the time of diagnosis and diagnosis was established due to abnormal sonographic finding and abnormal liver function tests during investigations for other causes. Hyperlipidemia (61.67%), diabetes mellitus (58.33%), obesity (46.67%) & overweight (50%) were the most commonly associated risk factors noted. 7 patients underwent biopsy. Of these 4.28% patient showed steatohepatitis, 42.86% patients showed simple fatty change and 14.28% patient had cirrhosis. Other 28.57% had no specific changes.
Conclusion: This study demonstrates that features suggestive of the metabolic syndrome are observed more frequently in patients with non-alcoholic steatohepatitis, share many of the systemic disorders that constitute insulin resistance syndrome, hyperlipidemia, hypertension, obesity, type 2 diabetes and hepatic steatosis.