Online ISSN: 2515-8260

Keywords : serum calcium


STUDY OF THE ROLE OF SERUM PARATHORMONE LEVEL AS A RELIABLE INDICATOR OF HYPOCALCAEMIA FOLLOWING TOTAL THYROIDECTOMY

Abhishek S Padil, M S Kannur, Yatheesh H M, Munawar Ala, Lancelot Lobo

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 12110-12115

Background: Postoperative hypoparathyroidism manifesting as hypocalcaemia is still one of the most common complications seen in patients undergoing total thyroidectomy, despite every effort by the surgeon to preserve the parathyroid glands during surgery. Incidence varies from 0.5 to 65%(1). In the present study, we aimed to evaluate the role of serum Parathormone level as a reliable indicator of hypocalcaemia following total thyroidectomy. Material and Methods: Present study was a cross-sectional, observational study conducted in all the patients undergoing Total thyroidectomy at a tertiary hospital.
Results: In this study, the total number of patients included was 42. 90.5 % were female, and 9.5 % were male. In the present study, 57.1% (n=24) had benign disease, and 42.9 %(n=18) had malignant disease. The mean serum PTH value was 16.38 ± 7.70pg/dl among the benign group and 13.66 ± 5.40pg/dl in the malignant group. Serum PTH was lower among the malignant group than the benign group but was not statistically significant. The difference between pre-operative and post-operative values of corrected calcium levels was statistically significant. The correlation between the pre-operative and post-operative corrected calcium parameters showed a good positive correlation and is significant with a p-value of 0.007. The post-operative corrected calcium (<8mg/dl) and serum PTH (<15pg/m) showed a good positive correlation with significant p-value of
Conclusion: Serum PTH hormone levels should be evaluated for all the patients undergoing total thyroidectomy at 24 hours postoperatively, which is a reliable early predictor for patients who can develop hypocalcaemia even before serum calcium levels drop and hence predicting patients at risk of developing hypocalcaemia and treating them prophylactically.

Study of thyroid disorders in relation to bone biochemical parameters

Sangeeta Kapoor, Biswajit Das, Shikha Saxena, Umme Afifa

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 1263-1269

Background: Thyroid hormones are essential for normal skeletal development and normal bone metabolism in adults but can have detrimental effects on bone structures in states of thyroid dysfunction. Present study was aimed to study thyroid disorders in relation to bone biochemical parameters (Serum calcium, Serum phosphorus, serum ALP & vitamin D) at a tertiary care hospital.
Material and Methods: Present study was single-center, cross sectional, observational study, conducted in patients with thyroid disorders, 18-70 years age, visiting Medicine OPD for their regular thyroid check-up, underwent estimation of thyroid hormones profile (TSH, T4, T3, serum calcium, serum phosphorus, serum ALP & vitamin D.
Results: In present study 300 patients, majority were from 36-45 years (47.67 %), female (71 %) and had co-morbidities as diabetes mellites (18 %), hypertension (29.67 %). Majority were euthyroid (38 %) while others were Hypothyroid (28 %), Subclinical Hypothyroid (20 %) & Hyperthyroid (14 %). Serum calcium levels in euthyroid patients (8.634 ± 0.711mg/dl) were more than that of hypothyroid patients (8.125 ± 0.838 mg/dl ), Subclinical Hypothyroid patients (7.760 ± 00.81mg /dl) & Hyperthyroid patients (8.10 ± 1.213 mg/ dl ), difference was statistically highly significant (p- 0.001). Serum phosphorus levels in euthyroid patients (3.634 ± 0.421 mg/dl) were less than that in Hypothyroid patients (3.80 ± 0.854 mg /dl), Subclinical Hypothyroid patients (3.690 ± 0.422 mg/ dl ) & Hyperthyroid patients (4.021 ± 0.698g /dl), difference was statistically significant (p- 0.004). Serum ALP levels in euthyroid patients (112 ± 39.806 mg/dl) were less than that of hypothyroid patients (138.143 ± 86.695 mg /dl) & more than levels in Subclinical Hypothyroid patients (94.90 ± 15.442 mg/dl) & Hyperthyroid patients (106.143 ± 31.749 mg/dl), difference was statistically highly significant (p- 0.001). Conclusion: All patients with various thyroid disorders should be periodically evaluated for bone biochemical parameters (Serum calcium, Serum phosphorus, serum ALP & vitamin D) for early diagnosis of bone related disorders and0 to decide treatment protocol.