Online ISSN: 2515-8260

Keywords : peptic ulcer disease


Dr. Anuradha Dnyanmote, Dr. Reina Khadilkar, Dr. Prajwal Shanti

European Journal of Molecular & Clinical Medicine, 2023, Volume 10, Issue 1, Pages 1908-1919

Global health concerns include peptic ulcer disease (PUD). Recent findings indicate a global decline in peptic ulcer disease. Peptic ulcer perforation remains a severe health concern despite all of this. The pattern of perforated PUD varies by location due to sociodemographic and maybe environmental factors. Perforated PUD is seen in young males in poor nations like ours. In comparison, perforated PUD patients in industrialised nations are mostly older and have smaller gender inequalities. Due to the close association between drinking and smoking among young males, emerging nations have high rates. Despite the high number of cases in our area, perforated peptic ulcer disease is rare. We aim to provide our hospital's experience with perforated PUDs, including incidence, clinical presentations, treatment results, and morbidity and mortality

Study of Risk Factors for Recurrence of Peptic Ulcer Disease

Dr. Abhishek Deepak, Dr. Subhendu Mohanty, Dr. Esha Singhal, Dr. Manisha Jindal

European Journal of Molecular & Clinical Medicine, 2023, Volume 10, Issue 1, Pages 2976-2979

Background: To study the risk factors for recurrence of peptic ulcer disease.
Materials & methods: A total of 100 subjects were enrolled. The age group included was 15 to 80 years. Possible risk factors including nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin and alcohol were analysed. Recurrence rate were assessed. Student's t-test was used to compare means, chi-square test was performed. A P-value of <0.05 was considered statistically significant.
Results: PUD was diagnosed using endoscopy and histology in 80 (80%) and by clinical diagnosis in 20 (20%) patients. The recurrence rate of PUD was 28% which was seen in 28 patients.
Conclusion: The recurrence rate of PUD was 28%. The use of NSAID and H. pylori infection were risk factors for recurrence of PUD.

Descriptive study of non-traumatic perforative peritonitis at a tertiary care hospital

Dr. Somashekhar L Samagandi, Dr. SB Rajashekar, Dr. Gurubasavana Gouda Yale, Dr. Vishwajith K

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 7, Pages 2155-2160

Introduction: Peritonitis is defined as inflammation of the serosal membrane that lines abdominal cavity and organs contained therein. Secondary peritonitis caused due to non-traumatic hollow viscous perforation is a common occurrence in this country which requires emergency surgical intervention. In our prospective study we tried to find out the incidence of perforative peritonitis which presented to our tertiary care hospital with respect to age and gender, relative frequency of anatomical site of perforation, their causes, presentation, treatment and outcome.
Methods: The study has been based on the analysis of 98 cases of non-traumatic perforated peritonitis patients admitted to our tertiary hospital, during the study period with prior inclusion criteria.
Each patient was examined thoroughly, after taking a detailed history and social demographic factors were noted. Cases were admitted as emergency and relevant immediate investigations were done. The diagnosis was made with history, clinical features and radiology to support the diagnosis.
Out of 98 cases, 92 underwent emergency laparotomy, at laparotomy the site of perforation, its pathological conditions, the amount of peritoneal contamination were noted. Perforation site specific operative procedures were done. In post-operative period, patients were closely monitored and complications were managed appropriately.
Results: Out of 98 cases 84(85.7%) were males. 25(32.7%) of the patients were in a age group of 21-30 years. Majority (35.7%) of the cases presented after 24-48 hours to our hospital. Pain abdomen was the most consistent symptom present in all the cases. Smoking (43.12%) and NSAIDs(21.4%) were the most important risk factors. Duodenum was the most common site of perforation (43.9%) followed by ileal (24.5%) and gastric (21.4%). In postoperative period 34.3% of patients had some form of complication and death occurred in 8 patients (8.16%).
Conclusion: Non-traumatic perforative peritonitis is more common in young age group (21-30 years) with male preponderance and is more common in rural population. Smoking and NSAIDs are the most common causative factors although it is multifactorial. Peptic ulcer disease is the most common cause of perforation. Delayed presentation to the hospital is the most common cause of morbidity and mortality

Clinicopathological Study Of Peptic Ulcer Perforation At Tertiary Care Hospital

Dr. Veershetty, Dr. Sagar Z, Dr. Dhananjaya BM, Dr. Ranjith BS .

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 7, Pages 9754-9762

Peptic ulcer disease and its complications remains a common problem encountered by surgeons all over, despite all the progress made in the diagnosis and treatment both medically and surgically for this condition. Among these, duodenal ulcer is definitely more prevalent than gastric ulcer. The study period was 22 months including follow up, comprising of 55 patients, who are satisfying inclusion criteria admitted in Tertiary care centre. It is a prospective, descriptive study. In our study males are affected more commonly than females, with 20-30years being the most common age group. Duodenal ulcer perforation predominates over gastric ulcer perforation with benign condition being the most common cause behind perforation, and patients diagnosed clinically and radiologically and treated surgically(Graham’s/modified Graham’s omental patch repair). Earlier the presentation better is the prognosis and also probability of early discharge and lower medical co-morbidities.


Dr. Vijay BN

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 12137-12140

Immediate treatment of perforated ulcer has been established procedure for some time now. It can be stated that immediate definitive surgery like truncal vagotomy with drainage procedure or proximal gastric vagotomy (PGV) after simple closure with or without an omental patch, for a perforated peptic ulcer offers the prospects of a permanent cure with a mortality and morbidity comparable to that of patients with elective surgery, also chances of complication like the biliary leak after simple closure of perforation is much less than after definitive surgery for perforated duodenal ulcer. Out of 50 cases admitted, all 50 cases were subjected to emergency laparotomy. At laparotomy, site of perforation, size of perforation and amount of peritoneal contamination were determined. Following definitive procedure i.e., closure of perforation with posterior G.J. or with bilateral truncal vagotomy and simple closure of perforation with or without omental patch were done. Simple closure of perforation with omental plug (Graham's patch) was procedure of choice and was done in 39 cases (78%). Definitive surgery (bilateral truncal vagotomy with posterior gastric-jejunostomy) was done in 11cases (22%) definitive surgery was done in those patients, who had perforation for less than 24 hrs. were hemodynamically stable and who had previous history of peptic ulcer disease and were treated for PUD (Patient having Chronic Ulcer) similar seasonal variation of perforation.