Keywords : systemic involvement serological diagnosis
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 1, Pages 1666-1673
Background: Dengue fever is an acute febrile illness, approximately 0.3-14.9% develops severe manifestations that result in ICU admission, and 1-5% dies without early recognition and proper treatment. Present study was aimed to study clinical outcome in patients with dengue syndrome at a tertiary hospital.
Material and Methods: In present study was hospital based, observational study, conducted patients > 18 years age, had acute fever of < 10 days duration, had positive dengue serology (IgM antibodies/ NS-1) after at least 5 days of onset of fever. Treatment details were noted & final outcomes were analysed.
Results: In present study, 130 patients satisfying study criteria were included. Majority patients were from 31-40 years (29.23 %) followed by 41-50 years (24.62 %) & 19-30 years (21.54 %). Male patients (63.85 %) outnumbered female patients (36.15 %). Majority of patients had DF with warning sign (59.23 %), Dengue without warning sign (26.15 %) & Severe Dengue fever (DHF) (14.62 %). 23.85 % patients required hospitalization for > 6 days. Common clinical features in present study were fever (96.92 %), headache (83.85 %), myalgia (63.85 %), body pain (53.85 %), vomiting (43.08 %) & joint pain (33.08 %). As per dengue serology majority were NS 1 positive (75.38 %) as compared to NS1 positive + antibody (IgM) (24.62 %). In cases of severe Dengue fever (DHF) (n= 19) crystalloids (100 %), colloids (78.95 %), PRBC (57.89 %), platelets (73.68 %) & FFP (31.58 %). Most of patients discharged uneventfully (68.42 %) while 5 deaths (26.32 %) were noted. Overall mortality in present study was 5.38 %.
Conclusion: Severe dengue disease, platelet count less than 50000, systemic involvement were common findings among patients died during course of treatment.