Online ISSN: 2515-8260

Keywords : Burden

Drug Resistant Tuberculosis – Clinical profile and Resistance pattern in tertiary care teaching hospital.

Dr Rohit Dixit

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 7, Pages 548-554

Background: This drug resistant TB is a growing concern around the world. It accounts for huge financial and public health burden. Though drug resistant TB is not new to India but proper surveillance and treatment remains the mainstay in tackling this global problem. The primary objective was to study the clinical profile and drug resistance pattern of TB patients. The Secondary objective was to effectively diagnose and treat the DR TB.
Methodology: It was a cross sectional observational study conducted at department of General medicine at Raichur Institute of Medical Sciences (RIMS), Raichur. All the patients of Drug resistant tuberculosis (DR TB) who attended RIMS were included in the study. All the patients with drug resistance pattern were included in the study after taking their consent. Statistical analysis was done using SPSS Ver 21.
Results: A total of 552 TB cases were screened for drug resistance. Out of them 39 were found to drug resistant TB. The mean age of presentation in males was 39.92 years and in females it was 36.08 years. Patients who completed higher education and who were employed were more in number compared to others. All the classical symptoms of TB like cough with expectoration, fever, shortness of breath was seen in these patients. Among the 39 DR TB patients, 30 patients had previously suffered from TB. Out of these 30 patients, 18 (60%) were defaulters, 7 (23%) were irregular and 4 (14%) were treatment failure. Thirty two (82.05%) patient showed resistance to either Rifampicin or INH and remaining 7 (17.95%) patients showed resistance to both rifampicin and INH.
Conclusion: Drug resistance was predominantly mono resistance to either rifampicin or INH but MDR TB were also seen. Patients were educated regarding treatment compliance

Association of caregiver burden with cognition in persons suffering from Schizophrenia

Dr. SVR Naga Pavan Kumar Kampalli, Dr. Prasanna Kumar Neredumilli, Dr. Phaniram Vavila

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 5, Pages 39-45

Introduction: Schizophrenia is a chronic psychiatric illness which ahas enormous impact on the persons suffering from the illness as well as the persons taking care of them. Cognitive deficits are common in the persons suffering from Schizophrenia, which further lead to impairment in the daily living of the individual. Caregiving of persons with Schizophrenia places a significant burden on the caretakers and this study tries to study the association between the caregiver burden and the cognitive deficits in persons suffering from Schizophrenia.
1)      To measure the cognitive deficits in persons suffering from Schizophrenia.
2)      To find the caregiver burden in the caregivers of persons suffering from Schizophrenia.
3)      To find the relationship between the caregiver burden with cognition of persons suffering from Schizophrenia.
Materials and Methods: This is an cross-sectional study and the study sample consisted of 60 persons suffering from Schizophrenia and their respective caregivers attending the Government Hospital for Mental Care, Visakhapatnam. Persons suffering from Schizophrenia’ cognitive status was assessed using the Cognitive Assessment Interview (CAI). Caregivers’ sociodemographic data was taken and the caregivers’ burden was assessed using the Burden Assessment Schedule (BAS). Statistical analysis of the data was carried out using SPSS software version 23.
Results: The mean Global Cognitive assessment score was 2.73 with a S.D. of 0.74. The mean score of caregiver burden according to the BAS was 76.9 with a S.D. of 6.7. There was a statistically significant correlation between the global cognitive score and the caregiver burden (r=0.783, p<0.01).
Conclusions: This study concludes that there is cognitive impairment seen in persons suffering from Schizophrenia. Caregivers of persons suffering from Schizophrenia have significant burden. There is a significant correlation between the cognitive impairment and the caregiver burden.