European Journal of Molecular & Clinical Medicine

Background: Propofol is one of the most commonly used anaesthetic drugs. Extensive researches have been done on the factors affecting the induction dose requirement of propofol forbetter hemodynamic stability. In the literature there is no mention on the dose requirement of propofol in the hydrated patients. This prospective randomized double blind study was done to assess the effect of preloading on induction dose requirement of propofol in patients undergoing general anaesthesia requiring endotracheal intubation.
Materials and Methods: Two hundred forty adult patients requiring endotracheal intubation under general anaesthesia were randomly divided into two groups, the study group and the control group. Study group received 20 ml/kg of normal saline over 2 hours, 4 hours prior to the induction of general anaesthesia and control group did not receive any fluid preloading. General anaesthesia was induced with titrated doses of propofol with the aid of BIS monitoring. The dose requirement of propofol, hemodynamic stability (HR, SBP, DBP and MAP was measured at intubation (0 min), 1 min, 2 min, and 3 min post intubation) and awareness during anaesthesia was assessed in both the groups.
Results: The dose requirement of propofol in the study group was 00.62±0.12 mg/kg and 1.24±1.30mg/kg in control group. There was no clinically significant change in the hemodynamic parameters between both the groups. None of patients in either group had awareness under general anaesthesia which was assessed post operatively using Brice questionnaire.
Conclusion: Crystalloid preloading reduces induction dose requirement of propofol during general anaesthesia with better hemodynamic stability.