Online ISSN: 2515-8260

Keywords : Non alcoholic fatty liver disease


BIOCHEMICAL CHARACTERISTICS OF NON-ALCOHOLIC FATTY LIVER DISEASE

Ms. Sophy; Dr. Anand Thirupathi

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 8, Pages 62-68

Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease. It encompasses a spectrum of conditions associated with lipid deposition in hepatocytes. It ranges from nonalcoholic steatohepatitis to advanced fibrosis and cirrhosis. The disease is mostly silent and is often discovered through incidentally elevated liver enzyme levels. This study was to analyze the distribution of non-alcoholic fatty liver disease (NAFLD) with reference to age, gender, and socioeconomic status, to look for clinical features A total of 3762 residents were included in the present study including 2328 males and 1434 females with a mean age of 46.37 ± 14.28 years (range 20–92 years).   Measurements were taken for assessment of BMI and blood samples were collected for estimation of fasting blood glucose, Triglycerides, Cholesterol, Alanine transaminase, Aspartate transaminase, Total bilirubin, HDL and LDL.  All the nonalcoholic fatty liver disease patients studied are either overweight or obese and 92% of them are glucose intolerant or diabetics. The fasting blood glucose, serum triglyceride, serum cholesterol, serum uric acid, ALT and ALT/AST ratio values are significantly increased in NAFLD patients compared to controls. Uric acid and ALT/AST ratio are showed best overall discriminatory capacity among all biochemical parameters for NAFLD. NAFLD can be seen in both male and female patients associated with Insulin resistance syndrome and oxidative stress. The ALT/AST ratio is the better biochemical marker for diagnosis of NAFLD.  More large-scale prospective studies can validate our observations, help physicians in early identification of patients who may benefit from therapeutic interventions, and even help them formulate more effective treatment algorithms.  

Frequency of Non-Alcoholic Fatty Liver Disease in patients withDiabetes Mellitus in a Tertiary care Hospital from Southindia

Dr. Charan Neeradi Dr. Triven Sagar Sandepogu Dr. Nagasandhya Katta Dr. Chennakesavulu Dara Dr. Phani Krishna Telluri

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 6, Pages 242-250

Introduction: Nonalcoholic fatty liver disease (NAFLD) prevalence is high, especially in patients with obesity and type 2 diabetes, and is expected to rise steeply in the coming decades. Objective:  We estimated NAFLD prevalence in patients with type 2 diabetes and explored associated characteristics and outcomes.
 
Material and Method: This is a prospective and cross-sectional study was conducted in the Department of Medicine at Tertiary care Teaching Hospital over a period of 6 months. The study population comprised of male and female patients who were diagnosed as having type 2 diabetes mellitus based on their fasting and random blood sugar levels. Frequency and percentages were calculated for categorical variables like sex and non-alcoholic fatty liver diagnosed on abdominal ultrasound. Non-alcoholic fatty liver was stratified among the age, sex and duration of type-2 diabetes mellitus to see the effect modifiers.
 
Results: Out of 320 participants, 200 patients (62.5%) had NAFLD on ultrasound. A total of 320 participants were enrolled for the study, of whom there were 140 (43.75%) males and 180 (56.25%) females. The mean age and mean duration of T2DM are presented. Overall, NAFLD was present in 200 (62.5%) study participants. Moreover, patients having NAFLD were compared with patients having no ultrasonographic evidence of NAFLD. There was no statistically significant difference between the two groups regarding mean age and gender distribution. Though, there was a statistically significant difference amongst the two groups in terms of HbA1c, triglycerides, total cholesterol, LDL and HDL cholesterol and serum uric acid.
 
Conclusion: This study reported an increased frequency of NAFLD in our diabetic population and evaluated in depth the risk factors associated with NAFLD, underpinning the significance of carrying further large-scale studies to assess the effects of lifestyle modification in the form of physical activity and dietary modifications on the status of NAFLD and glycemic control. Taking in to account the results of this study, patients and their treating physicians should emphasize on the modification of the associated factors and it is also advisable to screen diabetic patients for this condition in routine clinical practice. Early detection and timely management will help promote healthy lifestyle and prevent long term complications of the condition

BIOCHEMICAL CHARACTERISTICS OF NON-ALCOHOLIC FATTY LIVER DISEASE

Ms.Sophy, Dr. Anand Thirupathi

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 11, Pages 9599-9606

Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease. It encompasses a spectrum of conditions associated with lipid deposition in hepatocytes. It ranges from nonalcoholic steatohepatitis to advanced fibrosis and cirrhosis. The disease is mostly silent and is often discovered through incidentally elevated liver enzyme levels. This study was to analyze the distribution of non-alcoholic fatty liver disease (NAFLD) with reference to age, gender, and socioeconomic status, to look for clinical features A total of 3762 residents were included in the present study including 2328 males and 1434 females with a mean age of 46.37 ± 14.28 years (range 20–92 years).   Measurements were taken for assessment of BMI and blood samples were collected for estimation of fasting blood glucose, Triglycerides, Cholesterol, Alanine transaminase, Aspartate transaminase, Total bilirubin, HDL and LDL.  All the nonalcoholic fatty liver disease patients studied are either overweight or obese and 92% of them are glucose intolerant or diabetics. The fasting blood glucose, serum triglyceride, serum cholesterol, serum uric acid, ALT and ALT/AST ratio values are significantly increased in NAFLD patients compared to controls. Uric acid and ALT/AST ratio are showed best overall discriminatory capacity among all biochemical parameters for NAFLD. NAFLD can be seen in both male and female patients associated with Insulin resistance syndrome and oxidative stress. The ALT/AST ratio is the better biochemical marker for diagnosis of NAFLD.  More large-scale prospective studies can validate our observations, help physicians in early identification of patients who may benefit from therapeutic interventions, and even help them formulate more effective treatment algorithms.