Online ISSN: 2515-8260

Keywords : Cardiovascular function

Sympathetic Activity and Heart Rate Variability in Response to Cold Pressor Test and Hand Grip Test among Obese and Non-obese Adults: An Original Research Study

M.Shareefa, RVBS Sarma, Sunil Kumar.A.Rayan, Syeda Sobia Harmain

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 7, Pages 952-958

Background: Obesity is a health hazard throughout the world. weight gain and obesity are responsible for a growing threat to health throughout the world objectives: To evaluate and compare the cardiovascular autonomic response to cold pressor test and hand grip test among obese and non-obese adults.Methodology: Cardiovascular  sympathetic  function  tests were carried out in 100 obese adults  and  100 non obese adults  aged  between  28-58  years. Recording of ECG was performed in normal breathing, deep breathing and in condition of cold pressor.Time-domain method was used to record HRV Results: Study demonstrated significant decreased BP(BP)(systolic and diastolic) to cold pressor and to sustained handgrip. Responses in cases were significantly correlated to Body Mass Index. Our findings shows increased sympathetic activity was seen in obese patients and vagal activity was also withdrawn. Conclusion: There is remarkable change observed in the cardiac autonomic dysfunction responses between obese and non-obese subjects. Normal BMI showed a better HRV response to cold pressor test, indicating a better parasympathetic activity as compared to obese subjects. In cold pressor test BP was reduced in obese compared to non-obese individuals suggesting decreased vascular sensitivity to the amplified adrenergic activity in healthy obese individuals(adults).

A study to evaluate the association of HBA1C and Cardiovascular functions among the diabetic and non-diabetic population of a rural setting

K Amrutha, Dr. JM Harsoda

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 4, Pages 3628-3633

Introduction: Diabetes Mellitus (DM) has been progressively growing in prevalence over time, with overall annualised incidence rates per 1000 people rising from 3.0 in the 1970s to 5.5 in the first decade of the 2000s. This alteration resulted in an 83.3 percent rise in the incidence of T2DM, which was higher among males when compared with females.
Materials and Methods: This a prospective observational study undertaken at a rural tertiary care setting where two patient cohorts are made, one with diabetic patients and other with non-diabetic age and gender matched individuals. The study population (Cohort A) consisted of patients with type 2 diabetes attending the Medicine and Cardiology departments from January 2019 to February 2020. The Cohort B included age and gender matched non-diabetic individuals who are the relatives and attending staff of the patients and the working staff of the hospital.
Results and Discussion: HbA1c levels of 6.5 percent or higher in diabetics were linked to an elevated risk of cardiovascular disease. Glycosylation of haemoglobin may also affect RBC membrane lipid protein interactions, increasing internal viscosity, altering the viscoelastic properties of erythrocyte membranes and lowering RBC deformability.
Conclusion: HbA1c may be a valid predictor of cardiovascular mortality and morbidity in diabetics. The data of our study suggest that the healthcare professionals must appraise the values of HbA1c in assessing the cardiovascular risks and outcomes in the diabetes patients.