Keywords : CNS neoplasm
DEMOGRAPHIC PROFILE AND RESPONSE EVALUATION OF GLIOBLASTOMA MULTIFORME IN A CANCER INSTITUTE OF NORTH -WEST INDIA
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 6, Pages 400-407
Background & Objectives-
Glioblastoma multiforme (GBM) is the most common CNS neoplasm worldwide .The aim of this
study is to identify the demographics and response evaluation in the patients of GBM ,diagnosed
between the year 2015-2022 in a cancer institute of Punjab in North West India and determine its
significance, while comparing results with national and international standards.
Materials and Methods-
Demographic data of patients of GBM who underwent treatment at our institute between the year
2015-2022 was obtained retrospectively and comparative evaluation of MRI findings pre and post -
treatment after 6-8 weeks was done, which was followed by response evaluation with the Revised
RECIST guideline (version 1.1).
A total of 82 patients (44 males; mean age 45.61±15.96 years and 38 females; mean age
46.07±15.14 )were diagnosed with GBM over the period of 2015 to 2022 .The incidence is highest
amongst the age group 41-50 years in males (14.63%) and 31-40 years in females (17%).Out of 82
patients ,16 patients (19.51%) achieved a Complete Response (CR) ,47 patients (57.32%) achieved
a Partial Response(PR),14 patients(17.07%) had a Progressive disease(PD) and 5 patients(6.10%)
had a Stable Disease(SD). Complete Response was higher in females(13.41%) than males(6.10%).
The present study on the demographic profile of GBM patients in a cancer institute of Punjab in
North West India between the year 2015-2022 produced overall incidence higher in males (54%)
and in the age group (41-50years in males) and (31-40 years in females) which is a decade earlier
than found in international studies ,while being at par with previous studies conducted in India.