European Journal of Molecular & Clinical Medicine

Uterine Arterio Venous Malformation is defined as the rare pathology and difficult to quantify, with approximately 100 cases reported in the literature. Yazawa & O'Brien suggested pelvic sonographies of patients to rule out cause of  uterine bleeding, reported variable incidences of Arterio Venous Malformation 4.5% and 0.6% respectively.(2) Main Pathophysiology is formation of  direct communication amongst uterine arteries and veins & absence of intervening capillaries. It is life-threatening as profuse bleeding per vagina is the typical presentation. In this article, 32 year female G2P1L1 (Urine Pregnancy Test was done in the hospital) with amenorrhea since 2 months followed by vaginal bleeding since 20 days. Ultrasound of pelvis -increased vascularity with involving vessels of sub-endothelium and myometrial and Retained Products Of Conception, which complicated the diagnosis. She was investigated. As she was hemodynamically stable, she underwent expectant management and responded well

Objective: Uterine artery Doppler flow assessment during early pregnancy can help in the prediction of pre-eclampsia. The present study aimed to assess the role of uterine artery Doppler ultrasound in early prediction of pre-eclampsia at 13-16 weeks of gestation.
Methodology: This observational study included 80 antenatal women, aged 16-35 years, with 13-16 weeks of gestational age with singleton pregnancy, from December 2017 - June 2019. Demographic data, medical history was collected. Doppler assessment of the uterine arteries was performed at 13-16, 24-26 weeks of gestation to record uterine artery diastolic notch (UADN) and uterine artery Doppler indices, viz, resistance index (RI) and pulsatility index (PI). Pregnancy events, delivery and neonatal outcome were noted during follow up. Statistical analysis was performed by using R software (Version 3.6.0).
Results: Prevalence rate of pre-eclampsia was 12.5%.  At 12-16 weeks, UADN was seen in 35% cases with mean RI, PI of 0.62 and 0.96. At 24-26 weeks, it was noted in 15% of the study cases (RI: 0.53 and PI: 0.79). A significant (P<0.05) association was observed between UADN at 24-26 weeks and development of pre-eclampsia. At 13-16 weeks gestation, the specificity and positive predictive value (PPV) for UADN were 70.49 and 35.7%, respectively; whereas when UADN and RI were considered together, the specificity and PPV increased to 100%.
Conclusion: The uterine artery Doppler ultrasound effectively predicted the development of pre-eclampsia during early pregnancy (13 to 16 weeks gestation) screening.

Background and objectives:
Complications during pregnancy are frequently associated with adverse outcomes for the mother and foetus. These complications may result from preexisting maternal conditions and prior obstetric complications. A higher risk of developing intrauterine growth restriction, Hypertensive disorder is associated with impaired trophoblastic invasion of the maternal spiral arteries. The objective of study is the to predict this complication of hypertensive disorder and IGUR in 1st and 2nd trimester pregnancy by using Doppler study on uterine and umbilical arteries.
Method:
This study on Uterine and umbilical arteries Doppler Ultrasound assessment among pregnant women in 1st and 2nd trimester to predict hypertensive and IUGR disorder, There were a total of 200 women enrolled in the study, same 1st trimester pregnant women continuation with 2nd trimester for Doppler study. Data were obtained from 200 registered patients attending prenatal OPD in hospitals between 1st and 2nd trimester.
Results:
In the present study we found that Uterine artery Doppler RI: 12%, PI: 10 %, S/D: 12 % in first trimester, and Uterine artery Doppler RI: 38%, PI: 34 %, S/D: 38 %, ED Notch: 18 % in 2nd trimester and 15 % of women had raised SBP and DBP Of the total 200 pregnant women.
Conclusion:
Uterine and umbilical artery Doppler has potential. Clinicians would have the chance to stop the condition before it shows clinical symptoms by implementing an ultrasound screening programme in high-risk pregnant mothers.