Keywords : Hypertensive disorders in pregnancy
A PROSPECTIVE STUDY OF SERM CALCIUM, MAGNESIUM, URIC ACID AND LIVER ENZYMES IN PREGNANCY INDUCED HYPERTENSION
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 3, Pages 1328-1333
Introduction: Hypertensive disorders in pregnancy (HDP) are one of the deadly triads, along with hemorrhage and infection, and are responsible for 10.8% of maternal mortality in India. In preeclampsia and eclampsia, significant changes are seen in various biochemical parameters like uric acid and serum calcium. Hyperuricemia due to oxidative stress is associated with deleterious effects on endothelial dysfunction, oxidative metabolism, platelet adhesiveness, and aggregation. Hence, elevated serum uric acid is highly predictive of increased risk of adverse maternal
and fetal outcomes. Blood calcium has a relaxant effect on the blood vessels of pregnant women.
Materials and Methods: A prospective study was conducted at the department of Obstetrics and Gynecology, Kakatiya Medical College and MGM hospital, Warangal from1st October 2021 to 30th September 2022 (1 year).We have selected 100 cases and 100 controls. The control group was women who fulfill the same previously mentioned criteria, but who did not develop hypertension during the 3rd trimester. They were all normotensive with a systolic blood pressure of 130 mmHg or less and a diastolic blood pressure of 80 mm Hg or less.
Results: The present study includes 100 cases with pregnancy induced hypertension and 100 controls with normal healthy pregnancy. Age Distribution in Study Population Mean ± SD of age showed no significant difference with Mean ± SD of cases at 22.62 ± 3.61 yrs. compared to that of controls at 23 ± 4.04 yrs. and a p-value of 0.62. Gestational Age in Study Population Mean gestational age showed high significance with Mean ± SD of cases at 36.38 ± 4.19 weeks compared to that of controls at 39.62 ± 1.16 weeks with a p value of < 0.001.
Conclusion: Possibly, serial measurements of the serum uric acid and liver enzymes from early pregnancy can bring forward a selected group of high risk women for treatment. Thus, it can be concluded that Calcium and Magnesium can be evaluated at an early date so that such mineral deficiencies can be treated by appropriate Calcium and Magnesium supplements. Uric acid and Liver enzymes can possibly be used as biomarkers for identifying and avoiding adverse pregnancy outcomes by prompt intervention