Online ISSN: 2515-8260

Keywords : fentanyl as adjuvant to low dose bupivacaine


A comparative study of intrathecal bupivacaine versus fentanyl as adjuvant to low dose bupivacaine in cesarean section: Report from a tertiary care centre of Maharashtra

Kaushikee Ranjan Verma, Amol Bhalerao, Upendra Nath Verma

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 7, Pages 3393-3398

Introduction: The choice of anesthesia for cesarean section is determined by multiple factors, including the indication for operative delivery, its urgency, patient and obstetrician preference and skill of anesthetists. The aim of this study was to compare and determine the efficacy of intrathecal fentanyl as an adjuvant to bupivacaine in cesarean section.
Materials and Methods: An observational study was conducted by Department of Anesthesiology and critical care, Dr. Balasaheb Vikhe Patil Rural Medical College & hospital, Loni. The study duration was 12 months from November 2021 to October 2022. A total of 100 pregnant females were randomly divided into two groups, with 50 patients in each group: Group I: Received intrathecal injection of 0.5% hyperbaric bupivacaine 2 mL (10mg). Group II: Received intrathecal injection of 1.8 ml (8 mg) of 0.5% hyperbaric bupivacaine plus 0.5 ml (25 ug) fentanyl. Results were expressed as mean ±standard deviation or number (%). Comparison between different parameters were performed using unpaired t test. Comparison between categorical data was performed using chi squire test. The data was considered significant if p value < 0.05.
Results: The mean age of the patients enrolled in the study was 24.7 with a SD of 7.2 years. The duration of the surgery ranged from 76.2 minutes to 44.5 minutes with a mean duration of 50.4 minutes and a SD of 11.2 minutes. There was no significant difference between group I and II based on age distribution and duration of surgery.
Conclusion: By its synergistic effect with 0.5% hyperbaric bupivacaine it provides better intraoperative and postoperative analgesia, good hemodynamic stability, less incidence of complications like nausea, vomiting and shivering without compromising the safety of mother and the fetus.