European Journal of Molecular & Clinical Medicine

Background: The estimated prevalence of fatty liver in the general population averages around 14-25 % with rising prevalence in the presence of risk factors. Liver biopsy continues to be the ultimate and specific investigation for assessing the nature and severity of a spectrum of liver diseases. Present study was aimed to study clinical & histological profile of patients with nonalcoholic fatty liver disease.
Material and Methods: This study was retrospective and prospective, observational study, conducted in patients with increased echo texture of liver on routine ultra-sound scan, suggestive of fatty liver disease, prior to performing percutaneous liver biopsy, the proper preparation of a patient is important, with attention to a detailed knowledge of the procedure, a complete history and physical evaluation, medication use, and fresh clotting parameters.
Results: In present study, among 60 patients, 36 (60%) were females and 24(40%) were males. Majority were from the age group of 41- 50 years (36.66%), followed by 51-60 years (30 %).  Commonest symptom was fatigability and malaise (66.66%), followed by right upper abdominal discomfort (46.66%), Jaundice (10%), ascites (10%), UGI Bleed (8.3%) patients and 20 (33.33%) patients were asymptomatic at the time of diagnosis. The commonest clinical sign was of hepatomegaly or palpable liver (90%), edema (35 %), abdominal distension (18.33 %), splenomegaly (16.67 %) & icterus (13.33 %). Various risk factors noted were dyslipidemia (61.67 %), diabetes mellites (58.33 %), hypertension (53.33 %), overweight (50 %), obese (46.67 %) & coronary artery disease (40 %). 7 patients underwent biopsy. Of these 4.28% patient showed steatohepatitis, 42.86% patients showed simple fatty change and 14.28% patient had cirrhosis. Other 28.57% had no specific changes.
Conclusion: Our findings were consistent with the earlier concept that non-alcoholic steatohepatitis was prevalent in obese females with diabetes and hyperlipidemia.

Background: Liver biopsy is done for diagnosing liver diseases and is the gold standard for managing liver disorders, giving details of diagnosis, progression of disease and response to treatment.
Aim: To study liver biopsies and to correlate them with different age groups and to evaluate different hepatic lesions.
Results: A retrospective study of 60 liver biopsies was done during the period May 2021 to May 2022. Staining was done with H & E and the slides were examined using light microscope. Among these, 41 cases were males and 19 cases were females. Out of 60 cases, 14(23.3%) cases each were of cirrhosis and hepatocellular carcinoma, 11(18.3%) cases were of chronic hepatitis, 6(10%) cases were of fatty liver, 3(5%) cases were of biliary atresia, 4(6.6%) cases were of liver abscess, 2(3.3%) cases were of glycogen storage disorder, 1 case each of degenerative liver disease, liver cell dysplasia and miliary tuberculosis. Liver biopsy was inadequate in 3(5%) cases.
Conclusion: Examination using microscopy done in liver biopsy presents a spectrum of pathological variations and helps to diagnose the diseases and guides the physicians for appropriate treatment.