Online ISSN: 2515-8260

Keywords : Lycopene


OBTAINING OIL FROM RECYCLED MATERIALS AND ITS USE IN THE FOOD INDUSTRY

Xayrullo Qanoatov Murodullayevich; Dilorom Saribayeva Akramjanovna; Umidjon Rahimov Yunusjonovich; Omon Mansurov Abduvaliyevich

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 455-461

According to the analysis of the chemical composition of secondary raw materials during tomato processing, substances containing lycopene and unsaturated fatty acids in tomato have proven anticancer properties and are also used for atherosclerosis and ischemic diseases of the heart. Medical tomato oil, its use in various types of salad, dishes and canned meat contributes to normal digestion.

Enhanced Lycopene Delivery Using Estrogen Receptor Targeted Nanoparticles For Breast Cancer Therapy

Rajesh Khathuriya; Shailesh Sharma; Upendra K. Jain; Jitender Madan

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 2830-2836

Lycopene has extensively been shown to inhibit tumor growth in nude mice bearing Breast. However, high tumor-suppressive Lycopene dosages encumber the development of oral controlled-release formulations because of a short biological half-life (< 2 h), poor absorption, low aqueous solubility, and extensive first-pass metabolism. Here, we present the design, fabrication, optimization, characterization, and biologicalevaluation of estrone-conjugated lycopene -loaded gelatin nanoparticles for targeting estrogen receptor- positive breast cancer MCF-7 cells. Gelatin nanoparticles (GN) were uniformly compact sized, stable
at physiological pH, and showed good drug entrapment efficiency.