Online ISSN: 2515-8260

Keywords : Anti Tubercular Treatment

Lipid Profile Pattern among Tuberculosis Patients During Anti-Tubercular Treatment Period in A Tertiary Care Hospital at Mandya: Longitudinal Observational Study

Dr. Mohankumar C.K., DR. Bindiya J., Dr. Tejaswi Pritviraj H.K., DR. Hugara Siddalingappa

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 7, Pages 5008-5014

Background: Tuberculosis is one of the oldest diseases afflicting humans with significant mortality. Several studies have shown strong association between tuberculosis and hypocholesterolaemia, hypocholesterolaemia can be both consequence of tuberculosis or a risk factor for tuberculosis.
Methods: A longitudinal observational study was conducted inDepartment of Pulmonology of MIMS, Mandya for a period of one year from April 2021 to April 2022 recruiting 107 patients. Data was collected using Pre-tested semi-structured questionnaire including sociodemographic details, diagnostic details, treatment category, lab investigation details. 
Results: This study involved 107 newly detected tuberculosis patients. Total cholesterol at the diagnosis being 136.62, at the end of IP being 163.27, which increased to 182.57 at the completion of treatment. The mean triglyceride value at the diagnosis, at the end of IP and at the completion was 115.17,  134.37 and 152.21 respectively. The mean LDL levels showed increasing trend from the point of diagnosis to completion of treatment, the values being 89.71 at the diagnosis, 101.81 at the end of IP  and 113.1 at the completion of treatment. It was also found that mean HDL, LDL , VLDL and Triglyceride levels were found to show increasing trend during the course of treatment and pairwise analysis of the lipid profile in different phases of treatment was found to be statistically significant.
Conclusion: Completion of successful tuberculosis treatment is associated with increase in blood lipid levels, the current study adds to the existing literature