European Journal of Molecular & Clinical Medicine

BACKGROUND :-
Colon cancer is known to be the third most deadly and fourth most commonly diagnosed cancer in the world. In this research we study the anti-cancer properties of the plant leaf extract of Tecoma stans. There has always been a need for anti-cancer agents, since the commercially available synthetic drugs have their own limitations due to undesirable side effects. AIM :- To analyse the antioxidant and cytotoxic activity of Hydroethanolic leaf extract of Tecoma stans in colon cancer cell lines.
 
MATERIALS AND METHODS :-
Human colon cancer cell line (HT -29) was brought from NCCS, Pune, India. Cell viability test and Gene expression analysis were carried out for P-I3 and Akt mRNA Gene expression using MTT and PCR respectively. The results were analyzed using appropriate statistical tools.
RESULT :-
Results suggest that maximum reduction of cell proliferation was at dosage of (100-500 μg/ml) of the Hydro ethanolic leaf extract of Tecoma stans used in the study when compared to untreated group. At doses of 300 g/ml and 400 g/ml, the cancer cells were severely suppressed and mRNA expression of P-I3 and Akt was significantly reduced as compared to control.
 
CONCLUSION :-
The research carried out revealed that leaf extracts of Tecoma stans have diverse pharmacological spectrum and contain anti-cancer behavious. Research on this plant is increasing day by day because of its potent pharmacological uses. However further investigations involving the isolation on screening models of constituents are needed for further confirmation of various potential of Tecoma stans

Background :   Vigorous growth of cells leads to cancer. Tecoma Stans, a flower which consists of anti - cancer properties. One of such anti - cancer properties is the pro - apoptotic role in melanoma cell line (A-375). This is an in vitro study. The intervention is a hydroethanolic extract of Tecomastans on the melanoma cell line. The gene expressions chosen for this study are P53, caspase 3 and caspase 9. Aim of this study is to assess the pro apoptotic role of Tecomastans in melanoma.
 
Materials and methods : Human skin cancer (A - 375) was brought from NCCS, Pune, India. Cell viability test using MTT assay and Gene expression analysis for P53, caspase 3 and caspase 9 were carried out using MTT and PCR respectively. The results were analyzed using appropriate statistical tools using ANOVA and Duncan’s  test.
 
Results : The study suggestin MTT assay, the percentage of cell viability is observed to decrease on induction of Tecoma Stans.Caspase 9, mRNA  gene expression decreases on induction of dosages 300mg/ml and 400mg/ml of Tecomastans. P53 gene expression increases on induction of dosages 300mg/ml and 400umg/ml of Tecomastans. Caspase 3 gene expression doesn’t show any significance on induction of dosages 300mg/ml and 400mg/ml of Tecomastans.  
 Conclusion : Tecomastans consists of pro apoptotic property which is one of the anti cancer properties in melanoma when acted on the gene expressions P53, caspase 3 and caspase 9.

Flavonoids, alkaloids, quinones, tannins, and traces of saponins and amino acids were found in Tecoma stans. The presence of phytochemicals has been recorded in almost all sections of the plant (leaves, root, flower, seed, fruit, bark) and hence the plant's usage in medical domains. Cancer, along with cardiovascular illnesses, is one of the main causes of death worldwide. The goal of this study is to see if tecoma stans hydro ethanolic leaf extract has anti-cancer properties against liver cancer.
Human liver cancer cell line (HepG2 ) was brought from NCCS, Pune, India. Cell viability test and Gene expression analysis were carried out for Wnt and beta catenin mRNA Gene expression using MTT and PCR respectively. The results were analyzed using appropriate statistical tools

Background: Tumor is a disease caused by abnormal cells dividing out of control. Lung tumor is a type of tumor that primarily affects smokers. Coughing, wheezing, chest pain, and other symptoms of lung tumor include these. Tecoma stans, popularly known as yellow bells, flowering perennial shrub endemic to the United States that belongs to the Bignoniaceae family of trumpet vines. It possesses antimicrobial, antispasmodic, antidiabetic, antibacterial, and trypsin inhibitor effects, among other things.
Aim: to investigate on the lung tumour cell line A549, Tecoma stans hydroethanolic leaf extract has an antioxidant and anti-proliferative effect.