Online ISSN: 2515-8260

Keywords : Bcl-xl


The effect of exercise-induced dopamine replica in colon cancer cell line (HT-29) prevention via apoptotic signaling pathway

N.Vishal Prakasam; Lavanya Prathap; Selvaraj Jayaraman; Preetha. S

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 8, Pages 706-715

During exercise we release a lot of hormones and neurotransmitters. Dopamine is one among the hormones which is released in several parts of the mid brain during exercise. It is said that exercise can help to avoid many diseases and even cancer.. In 2020 the number of cases diagnosed were 104,610 all around the world .In this study we analysed the role of endogenous dopamine replica over gene expression of Apoptotic and tumor suppressor gene against colon cancer prevention.
Human colon cancer cell line (HT -29) was brought from NCCS, Pune, India. Cell viability test and Gene expression analysis were carried out for apoptotic and tumor suppressor gene using MTT and PCR respectively. The results were analyzed using appropriate statistical tools using ANOVA and Duncan’s test.

TECOMA STANS HYDRO ETHANOLIC LEAF EXTRACT ANTIOXIDANT AND ANTIPROLIFERATIVE EFFECT ON LUNG CANCER CELL LINE A-549.

Faaizah Fathima; Lavanya Prathap; Dr. Selvaraj Jayaraman; Preetha. S

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 8, Pages 716-728

Background: Tumor is a disease caused by abnormal cells dividing out of control. Lung tumor is a type of tumor that primarily affects smokers. Coughing, wheezing, chest pain, and other symptoms of lung tumor include these. Tecoma stans, popularly known as yellow bells, flowering perennial shrub endemic to the United States that belongs to the Bignoniaceae family of trumpet vines. It possesses antimicrobial, antispasmodic, antidiabetic, antibacterial, and trypsin inhibitor effects, among other things.
Aim: to investigate on the lung tumour cell line A549, Tecoma stans hydroethanolic leaf extract has an antioxidant and anti-proliferative effect.