Online ISSN: 2515-8260

Keywords : flavonoids

Role Of Flavonoids In Cancer Prevention: Chemistry And Mode Of Action

Harpreet Kaur; Tanu Bansal

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 3608-3625

Plants derived compounds have been successfully used as anti-cancer medicine so far. Paclitaxel, pomiferin, roscovitine are the few examples of plant derived drugs. There are a number of plant constituents which are being studied for their anticancer activity and still there are a number of natural products that are under various stages of clinical trial. Many researchers are working on these compounds so as to find out their mode of action and selectivity of cancer cell line. Exhaustive work is being done to get promising anti-cancer agents in future. In the present review, naturally occurring flavonoids have been considered and their role in controlling cancer is being investigated. A study of their mode of actions and categorization of their molecular targets have been done.


Dr. S. Kowsalya; Dr K.M.K. Masthan; Dr N.Aravindha Babu

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 1741-1746

Green tea becomes one of the most popular beverages consumed worldwide, because of its many scientifically proven advantageous effects on human health it has gained attention in recent years . which is also rich in health-promoting flavonoids account 30% of the dry weight of a leaf, includes catechins and their derivatives. Several studies has proved that green tea catechins, such as epigallocatechin gallate, prevent growth of periodontal pathogens and decrease the destruction of periodontal tissue.

In-Vitro Anti-Proliferative Effect Of Flavonoid Extract Of Amaranthus Viridis (Kolitis) Leaves Against MCF-7 Breast Adenocarcinoma Cell Line

Allysa Camille M. Malicdem; Michkaella Lorena O. Aducal; Jireh C. Cuasay; Denise Ansherina A. Dalisay; Alexander I. Mendoza; Glenda Marie E. Napiza; Carina R. Magbojos; Oliver Shane R. Dumaoal

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 4129-4140

Cancer is one of the major concerns in health and medicine. Studies have been done by previous researches on the medicinal value of flavonoids present in Amaranthus viridis. However, limited claims were available in terms of their anti-proliferative ability against cancer cells. Flavonoid extracts were prepared by semi-purification using ethanol and ethyl acetate. Phytochemical screening using UV-Vis spectrophotometry was used to verify the presence of flavonoids. MTT cytotoxicity assay using MCF-7 breast cancer cells was employed to determine the cytotoxic effect of the plant extract. Four concentrations of the extract of A. viridis leaves were used as treatment to cultured cells. Doxorubicin and DMSO were used as the positive and negative control, respectively. An inhibition concentration (IC50) of 18.33 ug/mL of the extract was reported after the assay, indicating that the administration of the treatment caused the death of the cells as seen when the yellow dye was not reduced into a purple formazan. Statistical analysis on the IC50 of doxorubicin and the A. viridis extract showed significant relationship, which indicated that doxorubicin has a more potent cytotoxic activity, though the extract had promising effects as seen in its IC50 being less than 30 ug/mL. These results can be attributed to the presence of the flavonoid quercetin which has been found out to possess cytotoxic effects against cancer cells. With these findings, a more natural, less toxic, cost-efficient and more readily available treatment regimen can be utilized for the management of cancer.


Parida Mirkhamidova; Dilnoza Babakhanova; Mavjuda Rahmatullayeva; Rano Alimova; Gafurjan Mukhamedov

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 886-898

The total amount of biologically active compounds - antioxidants, flavonoids, and vitamin C in different trees for example in Morusnigra L., Prunuspersica L., Serasus Vulgaris L., and Juglansregia L. leaves were found at different seasons. The results showed that the highest concentration of antioxidants in spring was found in walnuts and peaches than in the summer season. The number of walnut leaves was about 9.105 ± 0.05 mg/g, and in peach, leaves were about 9.082 ± 0.075 mg/g. In spring, the content of flavonoids in the leaves of grapes was high and amounted to 4721 ± 0.521 mg/g, in the summer their number was 3825 ± 0.255 mg/g, and in the fall there was a decrease in flavanoids to 1.460 ± 0.2253 mg/g. In the spring, in the stalks of grapes, flavonoids were 4.386 ± 0.046 mg/g, in cocoons 0.348 ± 0.023 mg/g.


Sudarsan R; Lakshmi T; Anjaneyulu K

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 1701-1713

A wide range of organic compounds that are naturally occurring called flavonoids are primarily found in a large variety of plants. Some of the sources include tea, wine, fruits, grains, nuts and vegetables. There are a number of studies that have proven that a strong association exists between intake of dietary flavonoid and its effects on mortality in the long run. Flavonoids at non-toxic concentrations are known to demonstrate a wide range of therapeutic biological activities in organisms. The contribution of flavonoids in prevention of cancer is an area of great interest in current research. A variety of studies, including in vitro experiments and human trials and even epidemiological investigations, provide compelling evidence which imply that flavonoids’ effects on cancer in terms of chemoprevention and chemotherapy is significant. As the current treatment methods possess a number of drawbacks, the anticancer potential demonstrated by flavonoids makes them a reliable alternative. Various studies have focussed on flavonoids’ anti-cancer potential and its possible application in the treatment of cancer as a chemopreventive agent. This article summarizes the effects of flavonoids in relation to its anticancer potential and its clinical application in treatment of oral cancer.

Quantitative And Qualitative Analysis Of A Liquid Extract Obtained On The Basis Of Wormwood

Yuldasheva Shahlo Khabibullaevna; Tukhtaev Khakim Rakhmonovich

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 3336-3345

The work is devoted to the development of the technology of composition and the study of the chemical composition of the liquid extract based on bitter wormwood - Artemisia Absinitum L. grown in the territory of Uzbekistan. The addition of tansy and pumpkin seeds to the composition of wormwood makes it possible to obtain liquid dosage forms with an enhanced anthelmintic effect. The study used methods of spectrophotometry, thin layer chromatography, qualitative chemical analysis, ionization plasma analysis, etc. The liquid extract was standardized by quantitative determination of flavonoids. A number of factors have been identified that influence the optimal technology for obtaining a liquid extract from plant materials. A method has been developed for the quantitative determination of the amount of flavonoids using spectrophotometry in the wavelength range of 350-450 nm. The content of the sum of flavonoids in extracts varies in terms of a standard sample of rutin in the range from 1.2860 to 1.5871% (mg / ml). For elemental analysis, the method of inductively coupled plasma mass spectrometry was used, on the basis of which important macro- and microelements were found in the composition of the liquid extract.
The studied indicators of the microbiological purity of the extract comply with the requirements of the State Pharmacopoeia XI issue 2.