European Journal of Molecular & Clinical Medicine

The Antiphospholipid syndrome (APS) is an autoimmune condition characterized by recurrent arterialor venous thrombosis and/or pregnancy morbidity in the presenceof persistently positive circulating antiphospholipid antibodies. Present study was carried out to study incidence of Antiphospholipid antibody syndrome and to study clinico-pathologic correlation of APS with special reference to Lupus anticoagulant.
Material & Methods: A prospective analysis was performed in 50 patients who were suspected to have Antiphospholipid syndrome as per the diagnostic criteria. Patients with history of thrombosis, recurrent miscarriages, or k/c/o SLE who were suspected of having Antiphospholipid syndrome were included in the study.
Results: Out of 50 patients which were included in our study, (24%) were males & (76%) were females. This showed that, there was a female predominance with F: M ratio of 3.16:1. The leading presentation was bad obstetric history (multiple miscarriages, etc.) in (56%) referred cases followed by Deep Vein Thrombosis in (10%) & Portal & splenic vein thrombosis in (10%) cases. (48%) cases showed prolonged aPTT while (52%) were normal aPTT. (32%) were DRVVT positive while (68%) cases were DRVVT negative. Thrombosis was leading presentation in (11.75%) dRVVT positive cases followed by (31.25%) of Bad obstetric history (12.5%) cases were BOH + DVT. Out Of 16 APS patients, (87.50%) cases had Primary APS & (12.50%) cases had Secondary APS.
Conclusion: we conclude that any obstetric / thrombotic event should be investigated further by aPTT / dRVVT testing to reduce morbidities associated with the complication