European Journal of Molecular & Clinical Medicine

The aim of the present study was to find a correlation between histopathological, radiological findings, and immunohistochemical findings in neoplastic breast lesions.
Methods: This study was a prospective study conducted at the Department of Pathology, Government Medical College and Rajindra Hospital Patiala, Punjab. A total of 70 cases of neoplastic breast lesions over a period of 2 years, which had BIRADS score reports, received in the pathology department as trucut biopsies, lumpectomy, and mastectomy specimens were examined histopathologically and immunohistochemistry (ER, PR, HER-2/neu) was done.
Results: In the present study, the age ranges from 14 to 80 years. Out of 70 patients with breast lumps, the highest percentage (42.9%) was seen in females aged 21 to 40 years (30 out of 70). Mean+ S.D age was 37.06 + 17.04. The median age was 35 years. The most common BIRADS category was category 3 with 30 out of 70 cases (42.9%) followed by category 4 with 21 out of 70 cases (30%). 10 cases (14.3%) were seen in category 5. In 70 breast lump cases studied, a broad spectrum of histopathological neoplastic breast lesions like benign, borderline, and malignant were identified. In benign breast lesions, the most common was a fibroadenoma, which was present in 48.6% of the cases. Among malignant breast lesions, the most common was an invasive ductal carcinoma which was present in 30% of the cases. 4 cases with borderline histopathology were also identified. A comparison of all the parameters showed a high diagnostic accuracy of 87.14%, a sensitivity of 89.66%, and a specificity of 85.37% in BIRADS and histopathology. Immunohistochemistry revealed 77.14% ER/PR positive and HER2 negative cases, 17.14% HER2/neu positive, 5.7% triple-negative, and 5.7% triple-positive tumors.
 
Conclusion: The present study concludes that, there is a statistical correlation between radiological (BIRADS), histopathological diagnosis, and immunohistochemistry findings in neoplastic breast lesions. All these techniques have high sensitivity, specificity, and accuracy in making the final diagnosis.
The aim of the present study was to find a correlation between histopathological, radiological findings, and immunohistochemical findings in neoplastic breast lesions.
Methods: This study was a prospective study conducted at the Department of Pathology, Government Medical College and Rajindra Hospital Patiala, Punjab. A total of 70 cases of neoplastic breast lesions over a period of 2 years, which had BIRADS score reports, received in the pathology department as trucut biopsies, lumpectomy, and mastectomy specimens were examined histopathologically and immunohistochemistry (ER, PR, HER-2/neu) was done.
Results: In the present study, the age ranges from 14 to 80 years. Out of 70 patients with breast lumps, the highest percentage (42.9%) was seen in females aged 21 to 40 years (30 out of 70). Mean+ S.D age was 37.06 + 17.04. The median age was 35 years. The most common BIRADS category was category 3 with 30 out of 70 cases (42.9%) followed by category 4 with 21 out of 70 cases (30%). 10 cases (14.3%) were seen in category 5. In 70 breast lump cases studied, a broad spectrum of histopathological neoplastic breast lesions like benign, borderline, and malignant were identified. In benign breast lesions, the most common was a fibroadenoma, which was present in 48.6% of the cases. Among malignant breast lesions, the most common was an invasive ductal carcinoma which was present in 30% of the cases. 4 cases with borderline histopathology were also identified. A comparison of all the parameters showed a high diagnostic accuracy of 87.14%, a sensitivity of 89.66%, and a specificity of 85.37% in BIRADS and histopathology. Immunohistochemistry revealed 77.14% ER/PR positive and HER2 negative cases, 17.14% HER2/neu positive, 5.7% triple-negative, and 5.7% triple-positive tumors.
Conclusion: The present study concludes that, there is a statistical correlation between radiological (BIRADS), histopathological diagnosis, and immunohistochemistry findings in neoplastic breast lesions. All these techniques have high sensitivity, specificity, and accuracy in making the final diagnosis.