European Journal of Molecular & Clinical Medicine

Background: Lichen planus (LP) is animmune mediated inflammatorydiseaseof skin and
mucous membranes without a clear etiology. Interleukin-6 (IL-6) is a pro-inflammatory
cytokinewith variousbiologicaland pathological impactson immunity, acute phase response
andinflammation. ExcessiveIL-6production can play a role in the pathogenesis of several
pathological conditionslike psoriasis.
Aim:This study aimed to evaluate serum IL-6 levels inLP patients alongwithassessment
ofitscorrelation with disease severity.
Patients and methods: Twenty-one adult patients with LP as well astwenty-one healthy adult
controls were enrolled in the study. The total score of LP severity was estimated for all
patientsby calculation of the affected body surface area in cutaneous LP patients and clinical
scoring system with visual analogue scale for pain assessment for oral LP.Serum IL-6 levels
were measured in all participants using enzyme-linked immunosorbent assay.
Results:The mean serumIL-6 levels were significantly higher in patients than controls (P <
.002). A positive correlation wasnoticed between serum IL-6 with both cutaneous LP (P
<0.004) and oral LP (P <0.005) severities.

Background: Juvenile idiopathic arthritis (JIA) is a term that encompasses all forms of
arthritis that begin before a patient is aged 16 years that persist for more than 6 weeks and
are of unknown origin. It is the most common childhood chronic rheumatic disease and
causes much disability. We investigated the relation of serum 14-3-3 η (eta) protein in
oligoarticular JIA (OJIA) and; the disease activity and severity.
Methods: This study is a case control study including 14 JIA patients and 14 control
group. Patients were (6 males and 8 females).14-3-3η was measured for all patients and
control volunteers by enzyme-linked immunosorbent assay (ELISA) technique. ANA was
measured by indirect immunofluorescence (IIF) technique. Disease activity was assessed
by the Juvenile Arthritis Disease Activity Score27 (JADAS-27). Functional ability was
assessed by childhood health assessment questionnaire (CHAQ), and disease severity was
assessed by juvenile arthritis damage index (JADI). Radiological damage was assessed by
Poznanski score.
Results: Elevated 14-3-3 η levels were detected in 5/14 (35.7%) patients. Positivity for 14-
3-3 η was significantly related to disease activity, severity and ANA. Positivity for 14-3-3 η
had no significant correlation with CHAQ or Posnanski score.
Conclusion: Serum 14-3-3 η can be detected in oligoarticular JIA patients, and appears to
correlate with disease activity, severity and (ANA). But no correlation with CHAQ or
Poznanski score.

Numerous studies in the past have been conducted to determine the prevalence of malocclusion in different populations. These show extreme variations and it is only right to determine the prevalence in a referred population. Class III malocclusion even though it is the least common, treatment planning and treatment is quite difficult, thus characteristics of class III malocclusion need to be studied in detail.The aim of the study is to evaluate the prevalence of crowding among patients with class III malocclusion visiting Saveetha dental college and hospitals. A retrospective study was done using case sheets of patients visiting the university hospital from June 2019- February 2020. About 100 case sheets of patients visiting the department of orthodontics containing information on malocclusion type and crowding was retrieved and analysed using SPSS 20.0. The study included 100 patients out of which 74% were males and 26% were females.Crowding was observed in 51% of the patients with class III malocclusion. Out of which 62.75% of the patients were reported to have minimal crowding ,31.37% had moderate crowding and 5.88% had severe crowding of the mandibular incisors. There was no statistically significant association between age, gender, and severity of crowding as determined by pearson's chi-square tests.Within the limits of the study, it can be concluded that mild mandibular crowding was the most common finding in class III malocclusion patients.

Dental fluorosis is a sign of prolonged high fluoride exposure. The aim of the study is to assess the severity of dental fluorosis among the patients visiting a Dental College in Chennai, Tamilnadu. A retrospective institution based study was conducted by evaluating and analysing 291 patient case records visiting a dental hospital from December(2019) to March(2020) who had signs of dental fluorosis. Data such as age, gender, type of dental fluorosis were documented from the online database of saveetha dental college - DIAS Dental Information Archiving Software. Ethical approval was obtained by the institutional ethical board at Saveetha University. The data was examined by two examiners. The data collected was reviewed and subjected to statistical analysis using IBM SPSS software version 20.0. The present study shows Females and middle aged patients with dental fluorosis visit dental hospitals more frequently.