Online ISSN: 2515-8260

Keywords : vaccination

Antibody response in healthcare workers to COVISHIELD vaccination in a tertiary care hospital

R Mahesh Reddy, Yasmin Muhammed, Kundan Tandel

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 1933-1939

Background: SARS CoV-2 infection has become a major public health concern. India started Covid-19 vaccination from January 16, 2021, after the approval of two candidate vaccines namely COVISHIELD ™ and COVAXIN ™. The present study was conducted to see the neutralizing antibody response to trimeric S protein of SARS CoV-2 in health care workers (HCWs) with 2 doses of COVISHIELD vaccination in a tertiary care hospital.
Methodology: A prospective cohort study was conducted among 156 healthy adult health care workers in a tertiary care centre, vaccinated during January-March 2021. They were divided into two groups, the first group comprised of individuals who were previously RT-PCR positive (n=36) for SARS CoV-2, and second group comprised of those who were RT-PCR negative (n=120). Blood samples were collected from all participants, the first sample on the day of vaccination, second sample after 4 weeks of vaccination, and third after 8 weeks of vaccination to measure the IgG antibodies against the SARS CoV-2 ‘S’ protein using a chemiluminescent quantitative immunoassay.
Results: The spike protein-specific IgG antibody titre was demonstrated reactive cut-off in 98.3% of the participants after 2 doses of vaccine. The median antibody titre declined from 710.5 (IQR, 338.5-1577.5) to 266 (IQR, 116-557.75) in RT-PCR positive HCWs after 8 weeks of vaccination whereas it increased from 45.1 (IQR, 31.475-76.575) to 83.4 (IQR, 52.075-104) in RT-PCR negative HCWs.
Conclusion: We could demonstrate the development of an adequate spike protein-specific IgG titre against SARS CoV-2 following vaccination with 2 doses of COVISHIELD in HCWs.

Adverse events following COVID vaccination among undergraduate students in a medical college, South India: A cross sectional study

Dr. Nandini RC, Dr. Tejashwini K, Dr. Shanthi M, Dr. Dilip Kumar, Nishitha Gowda

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 1786-1802

Background: COVID Vaccination has given a ray of hope in fighting against coronavirus disease 2019 (COVID-19).Since the experiences are relatively new to all, it is important to monitor safety of vaccines in a real-world setting. With this background, this study was conducted.
Objective: To assess the pattern of AEFI among undergraduate students.
Methods: This cross-sectional study was conducted in a Hospital setting with 200 vaccinated medical students being enrolled in the study and Data were analysed using SPSS version 20.00.
Results: Total of 200 medical students, 142(71%) and 74(37%) of study subjects had one or more AEFI following COVID-19 vaccination following 1st and 2nd dose respectively. All the AEFI’s (100%) were only minor reactions.
Conclusion: The study reflected that COVID-19 vaccination caused only mild and non-serious AEFI in most of the vaccine recipients. Hence the vaccine given can be considered safe. 

Immune Response Of The Organism Of Newborns Karakul Sheep Lambs To Vaccination

Ruzikulov R.F.

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 4438-4444

There was studied the immunological structure of populations of karakul sheep lambs, vaccinated against colybacterios, salmonellosis and anthrax antigen from the age of 2-3 days tile 2-3 weeks. There was revealed the nature of wavelike character of the immune reaction of an organism of newborn animals of vaccination. There was determined the immunomodulation role of anti idiotypic antibodies.

Treatment Strategies Of Cholera: A Review

Clara Basumatary; Rajinder Kaur; Sukhminderjit Kaur

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 4889-4899

Cholera is a contagious diarrheal disease which spreads through contaminated food and water. It is caused by Gram negative bacterium Vibrio cholerae of the O1 or O139 serogroup. Cholera can potentially spread as epidemic or endemic. If undiagnosed and untreated at the earlier stages, it can result in dehydration and death. Different endeavors are made for the treatment of cholera. Oral rehydration therapy (ORT), use of antimicrobials and antibiotics, probiotics and vaccinations are amongst the various alternative modes of treatment that can be used to treat cholera depending upon the severity of the disease. Also, antibiotics like tetracycline, azithromycin and doxycycline can be used synergistically for the treatment of acute infection and intense dehydration. Researchers have also advocated the use of different vaccines including oral cholera vaccine. In this review, we have provided a brief overview of the cholera disease and its pathogenesis along with different treatment strategies that can be used to treat it or reduce its symptoms.

Nasopharyngial carriage, serotypic landscape and sensitivity to S. Pneumoniae antibiotics in children before and after the implantation of vaccination in Uzbekistan

Elmira Shamansurova; Gulnoza Makhkamova; Shoira Agzamova

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 2393-2400

Abstract. This article presents the results of a study of the nasopharyngeal carriage of
Streptococcus pneumoniae in 76 organized children before vaccination and 77
unorganized vaccinated children in Tashkent. It was found that the frequency of
nasopharyngeal carriage of pneumococcus is higher in children of closed children's
groups. The disappearance of the most common pneumococcal serotypes after vaccination
indicates the effectiveness of vaccination


Karthiga Devi. G; Deepika Rajendran; Pradeep D

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 224-237

Infection control practices are important in a clinical setup to avoid the risk of infection among the patients and practitioners. Proper infection control measures such as proper basic disposal and sterilization of instruments that are basic infection control measures should be directly followed in a clinical setup. This study aims to access the knowledge, attitude and practice regarding occupational hazards and infection control measures among dental students. The study was conducted among dental undergraduates and postgraduates.The study group consisted of 3rd year, 4th year and Interns and Postgraduate students. Total number of students included in the study was 121 participants. The data was collected and analysed through IBM SPSS statistical analysis. Descriptive statistics were done. About 90.9% of the dental students answered that the dental clinics are more prone for infectious disease. Among all the dental students, 76.9% of the students experienced the accidental injury in clinics. Among them 44.6% of the students reported that needle injury was the cause for the occupational injury followed by 21.5% of scalpel blade, 4.1% of burs. About 11.4% of dental students were not immunized against Hepatitis B virus (HBV). Among them who received vaccination, 43.8% of them had completed the three recommended doses of HBV vaccination. The students know the importance of infection control and the knowledge among all students about the protocols about infection control was high but practice was quite low. A better knowledge of infection control is essential for safe practice in dentistry. This will ensure the provision of better and safer dental health-care service for the population.


Fahad Abdulrasheed Alafghani, Mohammad Qaseem Alturkostani, Ramez Saad Allehyani, Jaber Essa Alhaij, Basel Hussain ALrefaei, Bashaer Bashah Alnadwi, Amer Saeed alnadwi, Abdulrahman Hassan Alghamdi, Ebtesam abd almohsen fahad, Nehal Abdulrahman Koshak

European Journal of Molecular & Clinical Medicine, 2019, Volume 6, Issue 1, Pages 228-238

       The Kingdom of Saudi Arabia (KSA) annually hosts more than three million Muslim pilgrims from around 184 countries during the Hajj pilgrimage. Respiratory tract infection (RTI) is a major public health challenge during the Muslim pilgrimage to Makkah. It is necessary to take health precautions among these pilgrims the uptake of health preventive measures among Hajj pilgrims from Saudi Arabia, bacteremia, otitis media, and bacterial meningitis, in addition to a significant cause of sinusitis, osteomyelitis, septic arthritis, endocarditis, and peritonitis. Complications of each of these diagnoses are common. Pneumonia is one of the leading causes of hospitalization and intensive care unit among pilgrims in Saudi hospitals during Hajj. During the 1986 Hajj season, pneumonia was the second most common cause of hospitalization with the highest case fatality ratio among those aged over 50 years, therefore pneumococcal vaccination is recommended. Clinical symptoms, signs and physical examination findings alone cannot differentiate pneumonia disease from infections caused by other pathogens,to our knowledge there is no study that has explored the knowledge, attitude, and practices related to pneumococcal infection and vaccination among all Hajj pilgrims in KSA.
Aim of the study:To assessment of awareness and Attitude toward Prevention of Pneumococcal Infection and vaccination among Hajj and Umrah Pilgrims from Makkah in 2018
.Methods:Methods: Across sectional descriptive study conducted among pilgrims who resident in Makkah city during May 25, 2018 to 24 October 2018  Hajj 2018,  Our total Sample size of pilgrims participants were (500)
Results: the majority of participants (67.0%) have a weak knowledge while Range (1-21) Mean± SD (8.155±3.011). While more than half of them (61.0%) have a positive attitude about the disease, while Range (0-8) Mean± SD (3.944±1.098
)Conclusion:Before Hajj doctors must teach and inform all the participants about how to deal with any infectious disease, particularly pneumonia.Significant opportunities for improving Knowledge and awareness among Hajj pilgrims about the importance of using preventive health measures. Moreover, emphasizes the need for better communication between official health authorities in Saudi Arabia and all Hajj pilgrims regarding Hajj health information.