Online ISSN: 2515-8260

Keywords : prevention


MODERN CONCEPTS OF THE CAUSES OF DEVELOPMENT, PREVENTION AND PRINCIPLES OF TREATMENT OF DENTAL CARIES IN CHILDREN

Rakhmatova Dilnora Saidjanovna

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 1, Pages 1477-1482

Caries can have a significant impact not only on the condition of the dentition, but also on general somatic health in general. As a result of the progression of caries, the occurrence of pain can lead to a decrease in the child's ability and unwillingness to drink, chew, there is a restriction in the choice of foods (sour fruits and vegetables, solid food), loss
of appetite. Malnutrition can lead to weight loss, iron deficiency, and stunted growth and physical development

Covid-19 Infected Case Estimation In India Using 5-Pl Model

Parag Nijhawan; Parminder Singh; Vishika Goyal; Manish Kumar Singla

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 10, Pages 84-90

On 11th February 2020, Corona-virus was declared as a disease, COVID-19, by the World Health Organization (WHO). In December 2019, China became the first country to report its first case of COVID-19. The novel Corona-virus started spreading at an uncontrollable pace across the world and was therefore declared as a Pandemic disease in March 2020 by the WHO. In this manuscript, the India’s epidemic situation with total no. of days as 242, starting from 13th January till 10th of September 2020 is being predicted. The 5-PL model is used to predict the reported data. Nonlinear regression techniques in MATLAB to predict the parameters. In an attempt to do so, it has been observed that the prediction seems to be quite close to the actual on ground situation. This will certainly help the decision makers in implementing improved strategic decision making to counteract, and restrict the spread of the COVID -19.

Role Of Indigenous Agencies In Prevention And Handling Covid 19 In Indonesia

Miracle. Soplanit; Saartje Sarah Alfons r; La Ode Anggar; Sabri Fataruba

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 10, Pages 2165-2171

This study aims to determine and analyze the role of traditional institutions in the prevention and handling of covid 19 in Indonesia. The research was conducted using a normative juridical approach which was a descriptive analysis of qualitative analysis. This study found the answer that the Indigenous Archipelago Institution has a significant and strategic role in the prevention and handling of covid 19 in Indonesia. Indigenous peoples with a variety of local wisdom have a variety of ways to deal with the Covid 19 epidemic. This can be found in Southeast Maluku kei communities with Hawear adat (SASI) applied to prevent Covid 19, but also can be found in the Banua Lemo indigenous people, who are in the Village Bonelemo, West Bajo District, Luwu Regency, South Sulawesi. Baso 'Gandangsura, Head of the Bonelemo Village, stated that in the face of the Corona outbreak they had made various prevention efforts based on local local wisdom.

Improving the epidemiology, epizootology, and prevention of echinococcosis in Uzbekistan

Sh.M. Rasulov; G.S. Matnazarova; A. Mirtazayev; N.T. Xamzayeva

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 3029-3052

Echinococcus (Echinococcus granulosus) is a parasitic disease
that occurs in some mammals and humans, is transmitted orally, infects human
parenchymal organs (liver, lungs, spleen, and various other organs), and is
chronic, causing echinococcal vomiting. The Republic of Uzbekistan is an
endemic area for echinococcosis. According to official data, the damage rate is
6-9 people per 100,000 population. The number of surgeries performed
annually due to echinococcosis ranges from 1,000 to 1,500. The article
provides an analysis of the prevalence of echinococcosis among humans and
animals, the long-term (1994-2019) dynamics of echinococcosis among the
population of the Republic of Uzbekistan, routes of transmission, infectious
factors, epidemiological and epizootiological features.

Early Diagnosis And Prevention Of Dentoalveolar Anomalies And Cariogenic Situation In Children Suffering From Diabetes

Kamalova Feruza Rakhmatillaevna; Eshonkulov Golibjon Torakulovich

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 2468-2472

We examined 60 children from 5 to 17 years old in the regional endocrinological dispensary in Bukhara in the children's department with diabetes mellitus. The program "Healthy Tooth" was developed according to the following parameters: anamnesis of life, the state of the periodontium, the state of the mucous membrane of the oral cavity, the intensity of the spread of caries, the state of occlusion, the state of hygiene of the oral cavity, the state of the tongue. In all children, we took into account the following survey indicators: blood sugar level, age, hygiene index, PMA index and indices kp, KPU + Kp, KPU. At the same time, a comprehensive study of the oral cavity was carried out, which included the identification of patients' complaints, anamnesis, and a visual examination.

BIOLOGICAL EFFECT OF INFLUENCE OF PLANT AND SYNTHETIC PREPARATIONS ON EXPERIMENTAL ANIMALS ORGANISM AT CHRONIC INFLUENCE OF PHYSICAL AND CHEMICAL FACTORS

Khamrakulova Mukaddaskhon .; Sabirova Gulchehra .

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 2847-2862

Background:Experimental studies have confirmed the probability of
changes in some carbohydrate and protein metabolism indicators during
dichloromethane intoxication under the conditions of noise and vibration. It is
necessary to use Phytotea’ Gepalyuks’ with potassium for prevention and
treatment by correcting metabolic processes to avoid the adverse effects of
physical and chemical factors on the body.
Objective: Experimental study of the effectiveness of phytotea
“Gepalyuks” and potassium on carbohydrate energy metabolism of the liver and
blood under the influence of chemical and physical factors.
Methods: The experiments were conducted on 98 purebred white rats -
males weighing 160-180 years, contained in vivarium’s usual diet. Animals were
divided into control and experimental groups. Control animals received an
equivalent volume of drinking water, food and were kept in vivarium conditions.
Animals of the experimental group were divided into two groups: The first group
was intragastrically injected 10% of oiled dichloromethane solution in the dose of
1/20 LD50 (255 mg/kg) in conditions of noise (tape recording) at the level of 95-
105 dBA and vibration of 5-16 dBA during 90 days.
with intragastric administration of 10% oily solution of dichloromethane in a dose
of 1/20 LD50 (255 mg/kg), was administered a decoction of phytotea
“Gepalyuks”(1 ml of phytotea per 100 g of animal body weight) in conditions of
noise exposure (tape recording) at the level of 95-105 dBA and vibration of 5-16
dBA during 90 days. Phytotea “Gepalyuks” consists of immortelle sand flower,
yarrow herb, licorice root, peppermint leaves, corn snouts, and rosehip fruit.
Animals were slaughtered on 15, 30, 60 and 90 days from the beginning of the
experience. We took the liver, blood and determined biochemical indicators of
carbohydrate, protein, and pigment metabolism for research.
We studied some carbohydrate energy metabolism indicators to study the
effectiveness of phytotea“Gepalyuks” and potassium orotate under chronic
exposure to dichloromethane, noise and vibration.
Findings: When administered within 90 days, biologically active vegetable
and synthetic preparations in the form of decoction lead to an increase in the
activity of GDG, SDH and MDH and a decrease in the level of pyruvic and lactic
acids in serum and liver.
As a result of experimental studies, it was found that when administered
phytotea “Hepallux” in combination with potassium orotate for 90 days (15, 30,
60 and 90 days) under chronic exposure to dichloroethane, noise and vibration in
biochemical indicators - protein and lipid metabolism and activity of enzymes of
aliphatic amino acids remineralization (AST, ALT) and the content of cholesterol,
total and direct bilirubin in the liver and blood revealed a positive effect.
Conclusions: Application of phytotea “Hepallux” in complex
Potassium orotate causes a pronounced pharmacotherapeutic effect under
the toxic effects of chemical and physical factors - dichloroethane, noise and
vibration. Normalizes or approximates indices of carbohydrate energy (pyruvic,
lactic acids, the activity of GDG, SDG, MDG) metabolism and alkaline
phosphatase to those of the control group in blood and liver. The content of totalprotein, total and free bilirubins, the activity of AST, ALT in serum and liver is
approaching the norm.

Review on Mitochondrial Disease, Therapies and Preventive Measures

Shailza Verma; Sneha Mohan Singh

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 6, Pages 1343-1350

Essential mitochondrial ailment incorporates an amazing scope of acquired vitality insufficiency issue having exceptionally factor sub-atomic etiologies just as clinical beginning, seriousness, movement, and reaction to treatments of assorted multi-framework appearances. Huge advancement has been made in essential mitochondrial sickness demonstrative methodologies, clinical administration, restorative alternatives, and safeguard techniques that are custom fitted to major mitochondrial illness phenotypes also, subclasses. A large portion of the disease cases were grown-ups, and the conclusion of a mitochondrial issue in a grown-up quiet turned out to be moderately direct. Adults present with very much characterized "mitochondrial disorders" and for the most part convey mitochondrial DNA changes that are effortlessly recognized. Kids with mitochondrial scatters are a lot harder to characterize. The purpose of this paper is to review the advancements made for the treatment of mitochondrial diseases so as to prevent the victims from any adverse calamities.

Evaluation Of The Effectiveness Of Montelukast In Children With Recurrent Obstructive Bronchitis

Lim Maksim Vyacheslavovich; Shavazi Nurali Muhammad ugli; Kardjavova Gulnoza Abilkosimovna; Gaybullaev Javlon Shavkatovich; Allanazarov Alisher Boymuradovich

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 2507-2515

Background: The objective of the study was to evaluate the effectiveness of montelukast sodium in the treatment and prevention of recurrent obstructive bronchitis in children.
Methods: 80 children aged 1 to 7 years with recurrent obstructive bronchitis were enrolled and randomly divided into 2 groups. Group I (control) included 40 patients who received standard therapy. Group II (main) included 40 patients who received oral montelukast sodium. The effectiveness of the therapy was evaluated by cough relief, sputum separation, RDAI scale, and modified bronchophonography indicator.
Results: Patients who received montelukast had significantly accelerated elimination of cyanosis (by 0.7 days; P<0.05), cough relief (by 0.9 days; P<0.05), disappearance of respiratory failure (by 0.7 days; P<0.05) in comparison with the control group. Positive dynamics of indicator E:I index was observed on average starting from 3 days (P<0.05) until the last day of inpatient treatment (P<0.01) in patients of the main group in comparison with the control group. The anti-relapse effect of montelukast sodium, detected during follow-up of patients for 12 months after discharge, was established, so the frequency of repeated episodes of the disease was 33-59% less frequent in patients of the main group (P<0.01; P<0.001).
Conclusion: Using of montelukast sodium in recurrent obstructive bronchitis in children contributes to significant progress in the dynamics of the disease, leads to a significant decrease in the severity of bronchial obstruction according to the E: I index. The use of the drug causes a decrease in repeated relapses of the disease within 12 months.

Treatment Of Patients With Asymptomatic And Mild Case Of Covid-19 Infection And Its Prevention In Outpatient Basis By Using Infrared Resonance Therapy

Alisher Alimov; Rustam Rakhimov; Ulugbek Alimov; Alisher Azizov

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 5356-5358

About 7 months, the whole world has been plunged into the coronavirus pandemic. And each time, caronavirus infection surprises medical workers with its new abilities to affect various organs and systems of the body, which makes it more dangerous for humanity [5, 6].
Unfortunately, for now, there is no specific treatment and prevention for Covid-19 have not find out [7, 8]. Non-specific prophylaxis of coronavirus infection is aimed at to close borders and to stop spreading of Covid-19 into the territory of the Republic, regulated by the Resolution of the Cabinet of Ministers of the Republic of Uzbekistan dated March 23, 2020 No. 176 "On additional measures to prevent the spread of coronavirus infection", By the Decree of the President of the Republic of Uzbekistan No. PP-4649 dated March 26, 2020 "On additional measures to prevent the wide spread of coronavirus infection in the Republic of Uzbekistan", by the Decree of the President of the Republic of Uzbekistan No. PP-4652 dated March 26, 2020 "On additional measures to support medical workers and employees of the sanitary and epidemiological service involved in countering the spread of coronavirus infection. " Despite certain advances in drug therapy for patients with Covid-19, the number of temporary disability of patients for several months is increasing, as well as complications associated with thrombosis of the vessels of the heart and brain, leading to disability for all life.
In this regard, the improvement of methods of prevention and treatment in the rehabilitation period of patients with Covid-19 remains an urgent problem of medicine.
During many years in medical practice we use infrared resonance therapy according to the method of R.Kh. Rakhimov to treat various diseases, to disinfect viral infections, pathogenic microflora and to improve vascular microcirculation, as well as to increase immunity [1, 2, 3 and 4].

A Policy Design On Narcotics For The Prevention Of The Use Of Narcotics And Its Bad Impacts Reduction Due To Narcotics Abuse

Sunny Ummul Firdaus; Hartiwiningsih .

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 8, Pages 286-295

This research showed that Law of the Republic of Indonesia on Narcotics has not been able to actualize its legal objectives, particularly for narcotics users, considering that they are only ideally given rehabilitation sanctions, both medically and socially. On the other hand, they are not subject to criminal sanctions, in which it becomes the main legal sanctions. Besides, they get sentenced by the judges who use articles for narcotics traffickers in handling the crimes. Therefore, it is necessary to reformulate the right policies to manage the crimes in narcotics by providing legal certainty between the users and the traffickers, so they have a positive correlation with the way the judges decide cases based on legal certainty.

Positive Deviance Approach; an Efforts to Reduce the Incidence of Dengue Hemorrhagic Fever (DHF) in Pangkep Regency

Arsunan, A. A.; Masyitha Muis; Jumriani Ansar; Ridwan Amiruddin; Wahiduddin .; Indra Dwinata; Muhammad Akbar Nurdin; Rezki Elisafitri; Andi Dirpan; Aisyah .; Ahmad Yani

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 8, Pages 160-167

This study aimed to determine the effect of positive deviance approach on reducing the incidence of Dengue Hemorrhagic Fever (DHF) in Pangkep Regency. This studi used mix-method design to identify positive deviance behavior in preventing DHF and intervene by applying the positive deviance to the community in Pangkep Regency. The number of samples for quantitative data was 126 respondents and qualitative data was 12 informants. Data collection was conducted through Focus Group Discussion (FGD) and interviews. The research data were analyzed using logistic regression test and McNemar tests. The results showed the most influential factor in DHF incidence was positive deviance. Positive deviance behavior to prevent DHF were used long-sleeved clothing, use oil, and planting medicinal plants in the yard. The results of the intervention showed there was a significant influence of intervention using a positive deviance approach to increasing the planting of medicinal plants in the yard to prevent DHF, and there was a decrease in the incidence rate of DHF in Pangkep Regency. Positive deviance approach could be used as an effort to prevent and control DHF.
This study aimed to determine the effect of positive deviance approach on reducing the incidence of Dengue Hemorrhagic Fever (DHF) in Pangkep Regency. This studi used mix-method design to identify positive deviance behavior in preventing DHF and intervene by applying the positive deviance to the community in Pangkep Regency. The number of samples for quantitative data was 126 respondents and qualitative data was 12 informants. Data collection was conducted through Focus Group Discussion (FGD) and interviews. The research data were analyzed using logistic regression test and McNemar tests. The results showed the most influential factor in DHF incidence was positive deviance. Positive deviance behavior to prevent DHF were used long-sleeved clothing, use oil, and planting medicinal plants in the yard. The results of the intervention showed there was a significant influence of intervention using a positive deviance approach to increasing the planting of medicinal plants in the yard to prevent DHF, and there was a decrease in the incidence rate of DHF in Pangkep Regency. Positive deviance approach could be used as an effort to prevent and control DHF.

ORIGIN, EVOLUTION AND HISTORY OF COVID 19 - A REVIEW

Ganesh S,; Jothi priya .A; Lakshminarayanan Arivarasu

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 2222-2229

The coronavirus disease (COVID-19) is a highly transmittable and viral infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which arises in Wuhan, China and spreads all around the world. The Genomic analysis shows that SARS-CoV-2 is related to severe acute respiratory syndrome- like (SARS-like) bat viruses, so bats could be the possible primary reservoir for this disease. The intermediate source of origin is not known, the rapid human to human transfer has been confirmed largely. Most adults or children with COVID-19 infection are with mild flu-like symptoms and a few patients are in critical condition and develop acute respiratory distress syndrome, respiratory failure, multiple organ failure, even death of the individuals. The most commonly reported Symptoms are fever, cough, myalgia or fatigue,pneumonia, and complicated dyspnea,where's less common reported symptoms include headache, diarrhea, halmoprysis, runny nose, and phlegm producing a cough. Still There is no clinically approved antiviral drug or vaccine available for COVID-19.Few broad-spectrum antiviral drugs have been evaluated against COVID-19 in clinical trials, resulting in clinical recovery. The current review is about the history of covid 19.

KNOWLEDGE AND AWARENESS REGARDING RISK FACTORS FOR ORAL CANCER AMONG GAS AGENCY EMPLOYEES IN TIRUPUR

Roshan A; Dr.Keerthi Sasanka; Sridevi. G

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 1646-1657

Cancer is defined as the uncontrollable growth of cells that invade and cause damage to surrounding tissues. Oral cancer appears to be a growth or a pain in the mouth that doesn't go away. Oral cancer, including lip, tongue, cheek, mouth floor, hard and soft palate, sinuses, and pharynx (throat), can be life- threatening if not diagnosed and treated early. Cancer that occurs inside the mouth is sometimes referred to as oral cancer or oral cancer of the cavity. Mortal cancer is one of several types of cancer in a category called head and neck cancers. Mouth cancer and other cancers of the head and neck are often treated in the same way. This study was designed to create and assess awareness on oral cancer among employees of gas agencies in Tiruppur district. A self administered questionnaire prepared and circulated via google form link. The data was manipulated, analysed and tabulated. The obtained data was represented as cumulative percentage in pie charts. Association analysis between age groups of the participants and awareness on oral cancer was done by Pearson Chi square test (SPSS version 22) and the data was depicted in a Bar graph. The results of the study revealed that the participants were aware that smoking, chewing tobacco, and pan leads to increased chance of oral cancer. The present study concludes that the people of Tirupur were aware of the incidence of oral cancer and risk factors associated with it.

LIFE-SAVING ADVANCES IN SKIN CANCER TREATMENT

Yazhlini P; Dr Jayalakshmi Somasundaram

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 350-358

AIM: This study aims to find out about life-saving advances in skin cancer treatment.
INTRODUCTION: Skin malignant diseases are those that emerge from the skin. They are due to the development of abnormal cells that can invade and spread to different parts of the body there are three types of skin cancer- basal cell carcinoma, squamous cell carcinoma and melanomas. Hereditary factors strongly influence the risk factor of skin disease and malignant growth. Basal cell malignant growth develops gradually and can harm the tissue around it, however, it does not spread to distant areas or result in death. Squamous cell skin disease is bound to spread. Melanomas are the most aggressive. Although hereditary variables may have the least impact on skin management growth, most skin cancers are caused due to exposure to UV radiation.
MATERIALS AND METHODS: Review of various scientific literature was done in preparation of the manuscript. Several databases were searched for relevant articles from pub med and Google scholar. Databases of individual journals were searched for keywords such as skin cancer, sunlight on skin cancer, treatment, advances, prevention etc. The exclusion criteria were case reports, review and studies in other languages.
CONCLUSION: From the review, we can know about many recent advances for the cure of cancer. Personalised vaccines, cell therapy, gene editing and micro-treatment are newer technologies for treating cancer. In future cancer can also become a curable disease.

CHLOROQUINE AS A PROPHYLACTIC AGENT FOR COVID-19 INFECTION - A SURVEY AMONG SOUTH INDIAN POPULATION

Keerthana. B; Dr.R.Gayatri Devi; Dr.Ganesh Lakshmanan

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 822-831

COVID 19 being the deadliest disease all over the world regarded as the pandemic, the hope of every people is to get an effective medication that can counter it. There is a strong belief that chloroquine may help in controlling the virus. It is taken as an oral preparation. Chloroquine or hydroxychloroquine is a drug class 4- aminoquinoline. Chloroquine is contraindicated in people with heart disease or diabetes. It has a narrow therapeutic index and can cause toxicity easily.A derivative of chloroquine, hydroxychloroquine was synthesised first in 1946. Chloroquine is primarily used to prevent and treat malaria in areas where malaria remains sensitive to its effects. A self-administered questionnaire was prepared consisting of 10 questions and was distributed to a random population through Google docs and we got almost 100 responses. About 63% of the participants are aware of COVID-19 and chloroquine. SPSS software was used to analyse the data for descriptive statistics and chi-square analysis for association with gender. About 50% of the participants' perception is that chloroquine will protect them from COVID-19, and are aware that hydroxychloroquine and other forms of chloroquine are undergoing a clinical trial of COVID-19. If it succeeds it will have a big impact on the current crisis.

AWARENESS OF VARIOUS MEASURES TAKEN BY DIFFERENT GOVERNMENTS IN CONTROLLING COVID-19 PANDEMIC-A SURVEY

Thirukumaran .; Ganesh Lakshmanan; R.Gayatri Devi

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 492-500

Coronavirus is a newly discovered infectious disease, most people infected by coronavirus experience respiratory illness and require special treatment for recovery. Older people underlying medical problems like cardiovascular disease diabetes chronic respiratory disease develop serious illness.National responses to the COVID-19 pandemic have been varied, and have included containment measures such as lockdowns, quarantines, and curfews. More than 6.15 million cases of COVID-19 have been reported in more than 188 countries and territories, resulting in more than 371,000 deaths. More than 2.63 million people have recovered from the virus.The most affected countries in terms of confirmed cases are the United States, Spain, Italy, France, Germany, the United Kingdom, Turkey and China. The main aim of this study is to determine and rank the measures adopted by each country to fight against covid 19. An online survey was conducted with a self-structured questionnaire comprising 10 questions that were distributed through the google docs. The sample size of this study was 100. The results were analysed by performing the statistical software “SPSS VERSION 20”. The data was represented in the pie chart form. From this study population, 88% of the study population agreed that Covid 19 has to be controlled by all means. Nearly 70% of the population follows social distancing and 56% of them follow self isolation if they have symptoms and every country is working hard to contain it and minimise its impact. It is very important to prevent covid-19, because there is no vaccine found for treatment, preventive methods vary, and have measurements like quarantine, lockdown, curfews, sanitising our hands after coming home, using personal protective equipment. This study helps us to get knowledge about the measurements taken by different countries to control covid-19 and creates awareness on how to prevent covid-19.