Online ISSN: 2515-8260

Keywords : sensitivity


A Study to Correlate Preoperative Ultrasonographic Tirads Scoring System and Postoperative Histopathology of Thyroid Swellings

J.Parthasarathi, D.Ravisundar, M.Praveena, M. Anurag

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 2451-2460

Background:Aim & Objectives: To correlate preoperative TIRADS scoring system with postoperative histopathology of thyroid swellings.
Materials and Methods: A total of 66 patients of thyroid swellings who were treated at the Department of General Surgery, Govt Medical College, Nalgonda, with an age range of 20 – 68 years, were evaluated in this study with respect to age, sex, symptoms type and symptom duration and were investigated with routine hemogram, thyroid profile, FNAC and USG with TIRADS score. The results of USG TIRADS score were compared with the histopathology after excision of the thyroid swelling.
Results: Thyroid swellings are more common in females than in males (M:F ratio = 1:4). Majority of the patients are in the age group of 30-50 years. Swelling in front of the neck is the most common complaint. Majority of the patients had an average duration of symptoms of 6months to 3 years. On clinical evaluation all patients had swelling of thyroid. On USG with TIRADS scoring, TIRADS – 3 is the most common category of the thyroid swelling with 30 patients (45%). On USG TIRADS score, majority were benign lesions 55 (83%), while the rest were malignant 11 (17%). On histopathology, 55 lesions (83%) were benign, while 11 lesions (17%) were malignant. Incidence of malignancy with respect to TIRADS score is TIRADS 2- 4%, TIRADS 3 – 16.7%, TIRADS 4 – 50%, TIRADS 5 – 0%. The present study has a USG TIRADS score sensitivity of 45.5%, specificity of 89.1%, positive predictive value of 45.5%, negative predictive value of 89.1% and accuracy of 81.8%.  The prevalence of malignancy among the patients with thyroid swellings in the present study is 16.7%. USG proved to be a more sensitive modality to evaluate the nodularity of thyroid swellings than clinical evaluation.
Conclusion: The present study was undertaken to evaluate the usefulness of clinical evaluation and USG TIRADS score in management of thyroid nodules High resolution ultrasound is an accurate technique, that has helped to analyse the suspicious sonographic features of thyroid swellings and to assess the risk of malignancy and quantify it using TIRADS score.

Study of culture and sensitivity of renal stone culture

Dr. Kavitha H

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 2910-2914

Renal stones are quiet commonly encountered in this part of the world and are also associated
with complications. The tremendous loss of work hours by this disease is seriously impairing
the work hours as working young population is often hit with this disease. The demography is
never recorded in India but the demography of the western world is available. It is understood
that the stones that are encountered are the tombstones of the bacterias in majority of times.
Million Dollar question is whether the infection preseeds the stone formation or is a
consequence of the same. A number of reasons contribute for the stone formation as
previously recorded by different authors. Approximately 10% of people will have a urinary
stone during their lifetime. This study puts in an effort to find the culture and sensitivity of
renal stone.

DMIST Scale for Predicting Healing Time within 12 Weeks in Patients with Diabetic Ulcer

Suriadi, RN, Ph.D, AWCS; Wida Kuswida Bhakti, RN, Ph.D

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 10, Pages 2285-2293

Background: An assessment scale, namely, the DMIST (deep, moisture, infection/inflammation, size, tissue type of wound bed, type of wound edge and tunnelling/undermining), was designed to identify the healing time of chronic ulcers. An evaluation was then conducted to test the predictive validity of DMIST. This study aimed to evaluate whether the total scores from the DMIST scale could predict healing time of diabetic ulcer.
Method: A prospective study cohort was obtained from the Kitamura Wound Clinic in Pontianak, Indonesia. A total of 33 patients with diabetic ulcer were recruited to participate in the study. Collected data included DMIST score, demographic information, Wagner wound classification, neuropathic status, ankle brachial index, HbA1c level and wound images. Using the DMIST scale, trained data collectors scored patients every 7 days until ulcers were healed or patients were discharged.
Results: A cutoff score of 9 was valid as a predictor of non-healing after 12 weeks. The DMIST scale was found to have high sensitivity (90%) and specificity (96%). The area under the receiver operating characteristic curve was 0.98 (95% confidence interval, 0.856 to 1.000).
Conclusion: The DMIST scale was found to be a valid assessment scale to identify wound healing time in a period of 12 weeks in patients with diabetic ulcer.

Comparative Analysis Of MEMS Piezoelectric Energy Harvesters Capacitive Pressure Sensor Based On The Mechanical Vibrations Using Different Materials

T. Gomathi; Dr.Maflin Shaby

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 4692-4698

MEMS plays a vital role in manufacturing several electronic devices.It has a wide application in electronics manufacturing field.The fabrication of MEMS is very popular because of its miniature size,capacity power,sensitivity,etc. MEMS fabrication is possible even at high resonant frequency devices which can be operated at regular frequencies and greater bandwidths.Simulation is done using COMSOL multiphysics software.A surface capacitive pressure sensor has been simulated using different materials.The capacitance is analysed and the graphs are plotted.

DENTINAL HYPERSENSITIVITY

Dr. S.Aafiya Reshma; Dr K.M.K. Masthan; Dr N.Aravindha Babu; N. Anitha

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 1752-1760

The main aim of this review article is to provide information about Dentin Hypersensitivity(DH). Dentin Hypersensitivity ,a common condition of the teeth, characterized by short sharp pain arising from exposed dentinal tubules in response to stimuli. The article reviews its clinical features, pathogenesis, mechanism, diagnosis, prevention and management. The diagnosis should be accurate and all the differential diagnosis should be omitted. Desensitization remains the major choice for dentin hypersensitivity. The basic principle of treatment of dentin hypersensitivity is to block the patent tubules or block pulpal nerve response.

Non-invasive techniques for detection of oral potentially malignant disorders (OPMDs) - Detect early to treat early

S Swathi; Swetha P; Ravikanth Manyam

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 5, Pages 1206-1214

Oral potentially malignant disorders (OPMDs), the group of conditions with the risk of malignancy being present in a lesion or condition either at the time of early diagnosis or future date. Oral carcinoma is a major global, health care issue with high morbidity and mortality rates to date. Leukoplakia, Erythroplakia, Palatal lesion associated with reverse smoking, Oral Lichen Planus, Oral Sub Mucous Fibrosis, Actinic Keratosis, Discoid Lupus Erythematosus are other OPMDs. The aetiology varies from exogenous factors such as tobacco and various autoimmune disorders or inherited genetic aberrations. Early detection of the lesion is essential to prevent malignant transformation, and also to improve the chances of the patient’s survival. Though tissue biopsy and histological assessment is the gold standard diagnosis for OPMDs, in recent years, demand for non – invasive adjunctive diagnostic techniques are increasing for early detection. With this in view, the early diagnostic methods were divided into 3 main categories such as vital Staining, light-based detection systems, and optical diagnostic technologies. Among the recent developments in optical imaging systems, the tissue autofluorescence, optical coherence tomography have been proved to be considerably efficient. These techniques have proven valuable for screening and monitoring OPMDs. Awareness should be created in public in employing screening methods that are non-invasive, robust and economic thereby it would enhance early detection of oral cancer which gives a positive impact on patient’s survival. This review explains the sensitivity, specificity and limitations as well as their advantages, disadvantages and clinical applications of these techniques and to identify which one is better advisable and adaptable for all population groups

SENSITIVITY AND SPECIFICITY OF FINE NEEDLE ASPIRATION CYTOLOGY [FNAC] IN A THYROID SWELLING

H.V. Nerlekar; A. M. Shah; C.Z. Perdeshi; Amol D. Langale; Umesh B. Choughele

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 4156-4161

The current study was observational study undertaken to study sensitivity and specificity of FNAC in a thyroid swelling. It was observed that majority of patients with goiter were in age group 31-40 years. The majority of patients with goiter were females 50 (89.29%) as compared to males 14 (73.68%). The carcinomas were also more prevalent in females as compared to males. The results of thyroid cytology must be assessed in conjunction with the clinical findings and other investigations like TFT and USG findings, in view of the possibility of false negative or false positive cytological diagnosis. The viability and applicability of cell pattern analysis in applying pattern analysis to the understanding of thyroid cytology is also seen in this study.

VELSCOPE- A RECENT EXAMINATION TOOL IN DENTISTRY

Neha .; Dr. Jayalakshmi Somasundaram

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 359-366

Oral cancer is a global health disease that has a major impact on an individual's health, psychology and
lifestyle. It is the 6th most common cancer in the world and has a high prevalence worldwide, and is found
more in men than women. It is attributed to a myriad of causes which especially include tobacco smoking,
alcohol consumption and chewing betel quid. Survival rates of oral cancer are very poor despite advances
in therapeutic interventions. Detecting oral cancer at an early stage is believed to be the most effective
means of reducing death rates. Thus arises the need for an important diagnostic tool which is able to detect
pre-malignant and malignant lesions at an early stage. Treatment helps only for about 5 years after which
recurrences are seen. The only way to reduce recurrences is early diagnosis. VELscope, also known as
Visually-Enhanced Lesion scope, serves this purpose. It is an important diagnostic tool that uses an autofluorescence
based imaging system to detect lesions and allows enhanced visibility of the premalignant
and malignant lesions. It emits a harmless, non-invasive blue coloured LED fibre optic light that shines in
the patient’s mouth. The fluorescent light is absorbed by normal tissues whereas neoplastic lesions lose
fluorescence and become dark. This helps in quick and non-invasive diagnosis

Velscope- A Recent Examination Tool In Dentistry.

Neha .; Dr. Jayalakshmi Somasundaram

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 2475-2483

Oral cancer is a global health disease that has a major impact on an individual''s health, psychology and lifestyle. It is the 6th most common cancer in the world and has a high prevalence worldwide, and is found more in men than women. It is attributed to a myriad of causes which especially include tobacco smoking, alcohol consumption and chewing betel quid. Survival rates of oral cancer are very poor despite advances in therapeutic interventions. Detecting oral cancer at an early stage is believed to be the most effective means of reducing death rates. Thus arises the need for an important diagnostic tool which is able to detect pre-malignant and malignant lesions at an early stage. Treatment helps only for about 5 years after which recurrences are seen. The only way to reduce recurrences is early diagnosis. VELscope, also known as Visually-Enhanced Lesion scope, serves this purpose. It is an important diagnostic tool that uses an auto- fluorescence based imaging system to detect lesions and allows enhanced visibility of the premalignant and malignant lesions. It emits a harmless, non-invasive blue coloured LED fibre optic light that shines in the patient’s mouth. The fluorescent light is absorbed by normal tissues whereas neoplastic lesions lose fluorescence and become dark. This helps in quick and non-invasive diagnosis.