Online ISSN: 2515-8260

Keywords : SARS-CoV-2


Desirable And Undesirable Effects Of Air Purifier In Clinical Settings During Covid-19 Pandemic

Dr. Shilpi Gupta; Dr. Himangi Dubey; Dr. Amit Rai; Dr. Pallavi Singh; Dr. Nitin Jhunjhunwala; Dr. Shreya Singh

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 6, Pages 233-236

The novel SARS-CoV-2 virus which causes the COVID-19 disease, is mainly transmitted through contact with infected persons according to WHO. Breathing, as well as coughing and sneezing releases tiny infectious droplets into the air which potentially contaminate surrounding surfaces and of course the air in the immediate surrounding. These droplets, so called aerosols, can be of varying sizes, from 1 to over 10 μm (micron or micrometre, 1 micron equates to 0.001 mm). It is assumed by experts that viruses do not fly occasionally in the air but are always enclosed in droplets or attached to other particulate matter. This raises the question in which way ventilation and air-conditioning systems play a role in the transmission or containment of epidemic diseases like COVID-19. Maintaining a healthy indoor air quality thus becomes a general, basic – yet extremely important – necessity. While this is true at all times, it’s imperative in times of a wider health crisis to avoid not only the direct spread of a virus, but to support peoples immune systems to withstand more serious impacts by an aggressive disease and thus reducing pressure on a healthcare system fighting against overload.

Effectiveness of Dexamethasone for Acute Respiratory Distress Syndrome (ARDS) due to Coronavirus: A Systematic Review

Tri Setyawat; Ari Setiyawan Nugraha; Sarifuddin .

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 8, Pages 206-211

Estimates have suggested that up to 12% of patients hospitalized with COVID-19 have required invasive mechanical ventilation, with the majority developing acute respiratory distress syndrome(ARDS). Corticosteroids are the most potent anti-inflammatory drugs. The therapeutic mechanism of corticosteroids might base on attenuating the action of many cytokines that participated in the inflammatory reaction associating severe CAP However, the clinical and efficacy of dexamethasone in COVID-19 patients are currently unclear, so research is needed to know the effectiveness of dexamethasone therapy in patients with COVID-19. This research uses a structured analysis focused on preferred reporting items for systematic reviews and meta-analyzes (PRISMA) in order to classify all existing literature with appropriate keywords. The database using PRISMA (Preferred Reporting Items for Systematic Reviews & Meta Analyses) for instruments and used flowcharts based on the 2009 PRISMA checklist and based on inclusion and exclusion criteria, we found that dexamethasone resulted in a significant increase in the number of ventilator-free days (days alive and free of mechanical ventilation) over 28 days in patients with COVID-19 and moderate or severe ARDS.

COMPOSITION AND USES OF N95 MASKS -A REVIEW

J. Dhivyadharshini; Jayalakshmi Somasundaram; M. P. Brundha

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 1529-1540

The key aim of this article is to provide a description of the structure and uses of N95 mask that is necessary to advance Personal Protective Equipment ( PPE) during this COVID19 pandemic. Examples of personal safety gear designed to shield the user from infectious debris and from fluids contaminating the skin include the N95 respirators and medical masks (skin covers). A commercially available N95 respirator needs a suit factor of one hundred within the work-place to be deemed adequate. While we did not subjectively locate the respiration function needed with the prototype masks to vary from that necessary with a standard N95 filtering face device, this mask should not be used by people with respiratory risk of any sort. Although testers wear the masks easily for an hour, at any point in strenuous work or adverse environmental environments we can not think about their usefulness. This review offers detailed knowledge and appreciation of the structure, applications of N95 masks and, in turn, the advantages of N95 masks over other forms of surgical masks. Limitation and prospective range of the research were also addressed, as this subject is necessary to advance PPE in this COVID19 pandemic. This research contributes greatly to learning about the composition and uses of N 95 masks, and also helps to educate and make the general public informed of the critical role of N 95 masks during this pandemic assault.

OBESITY AS A MAJOR RISK FACTOR IN N- COV DISEASE

J. Dhivyadharshini; A.S.Smiline Girija; Jayalakshmi Somasundaram

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 367-375

The review gives an overview on the relation between obesity and n-CoV disease. A review has been done to understand the correlation of obesity with the n-CoV disease by retrieving a maximum of related articles from various search engines like PubMed, Google Scholar, MeSH, Core, Cochrane, bioRxiv, Semantic scholar and so on published from 2000 to 2020 (till date). Obesity is associated with SARS- CoV-2 which enhances inflammatory response in obese people compared to actual standard BMIs. Obesity is often specifically related to producing inflammation by triggering a cytokine storm in the lungs, which raises the likelihood of ARDS, thereby requiring respiratory assistance for the main issue. Obesity can hinder breathing by hampering the excursion of the diaphragm, inhibit immune responses to critical infection, it is pro-inflammatory and triggers diabetes and even oxidizing tension to worsen cardiovascular activity. This study indicates that obese people through respiratory viruses COVID19 are more likely to be hospitalized comparatively. The implementation of novel ideas on obesity control of ailments will certainly bring about a massive change. Constraining less dependence on recent literature in this area and also upgrading numerous research to increase consciousness among the general public so that they may take measures not to be vulnerable to COVID 19. The current research has shown a strong incidence of obesity in patients participating in medical treatment with SARS-CoV-2. Obesity can be hazard factored to SARS-CoV-2 severity which needs increased attention in susceptible individuals to take preventive measures.