Online ISSN: 2515-8260

Keywords : Epilepsy


FORECASTING EPILEPSY RISK IN CHILDREN BORN FROM PARENTS WITH EPILEPSY

Muslima Mambetkarimova; Dilfuza Ashurova; Yakutkhon Madjidova; Nadira Zakirova; Sherali Ergashev

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 2375-2381

This article details the condition of newborn babies from mothers with epilepsy.
The frequency and nature of epilepsy in children born to mothers with epilepsy are
described. Risk factors for the development of epilepsy in children born to mothers with
epilepsy were determined.

Assessment of Levetiracetam for the Treatment of Epilepsy

Ms. Samera Ali Siddique

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 6, Pages 889-896

Epilepsy is a disease related to central nervous system disorder where brain activity become unusual, thereby a patient experience a seizures or periods of strange behaviour, vibrations, and sometimes loss of consciousness. It might be due to genetic disorder or some sort of brain injury, such as shock or stroke. It requires a long duration treatment of drug therapy for getting cured. As per various researches half of patients do not pass the initial antiepileptic treatment and around 35 per cent are highly resistant to medical treatment, demonstrating the rising requirement for more effectual and improved tolerated medicines. Levetiracetam is an adjunctive management of seizures in victims with epilepsy, the fourth most general neurological chaos distressing individuals of different age groups. Its pharmacokinetic compensation comprise fast and approximately full absorption, limited irrelevant binding with plasma protein, no activation of enzymes, no connections with other products, and unfair metabolism external the liver.Yet another advantage is the provision of an intravenous injection. This has been shown to be efficient as adjunctive treatment for partial-onset refractory seizures, primary widespread tonic-conic seizures, and juvenile myoclonic seizure. In addition, controlled release of carbamazepine was found to be similar to first-line treatment for partial-onset seizure, together in effectiveness and acceptability.

Cytogenetic Evaluation of an Indian Boy with Ring Chromosome 14 Mosaicism: A Case Study and Literature Review

Neelam Thakur

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 4451-4454

The ring 14 chromosome is a rare chromosomal aberration characterized by a distinct
phenotype consisting of dysmorphic features including mental retardation, epileptic
seizures, ocular anomalies, microcephaly, pre-mature birth, late birth cry, skin
pigmentation, short neck and low set ears. Cytogenetic evaluation was done on 17 years
boy who was discovered to have previously undescribed chromosomal abnormality 42, XY,
14(r), -14 +Marker/ 44, XY. The parents had the normal karyotypes that indicate de novo
origin of this abnormality. Stanford - Binet test was performed to assess the degree of
severity of mental retardation and was found to be mild (IQ: 50-55 to 70). To our
knowledge this is the first report evaluated with ring (14) mosaicism. Literature of
published cases is reviewed in this article but none of these reports pertain mosaicism of
this type.

ADVANCED NEUROIMAGING TECHNIQUES IN EVALUATING PEDIATRIC EPILEPSY

K. Sree Kala Priyadharsini; Lakshminarayanan Arivarasu

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 376-382

Accurate localization of the seizure onset zone is important for better seizure outcomes and preventing
deficits following epilepsy surgery. Recent advances in neuroimaging techniques have increased our
understanding of the underlying etiology and improved our ability to noninvasively identify the seizure
onset zone. Using epilepsy-specific magnetic resonance imaging (MRI) protocols, structural MRI allows
better detection of the seizure onset zone, particularly when it is interpreted by experienced
neuroradiologists. Ultra-high-field imaging and postprocessing analysis with automated machine learning
algorithms can detect subtle structural abnormalities in MRI-negative patients. Tractography derived from
diffusion tensor imaging can delineate white matter connections associated with epilepsy or eloquent
function, thus, preventing deficits after epilepsy surgery. Arterial spin-labeling perfusion MRI,
simultaneous electroencephalography (EEG)-functional MRI (fMRI), and magnetoencephalography
(MEG) are noninvasive imaging modalities that can be used to localize the epileptogenic foci and assist in
planning epilepsy surgery with positron emission tomography, ictal single-photon emission computed
tomography, and intracranial EEG monitoring. These advanced structural and functional imaging
modalities can be combined with postprocessing methods to better understand the epileptic network and
obtain valuable clinical information for predicting long-term outcomes in pediatric epilepsy.