Online ISSN: 2515-8260

Keywords : Seizure


Clinical profile and prognosis of prenatal and postnatal women who presented with seizures in a central India tertiary care hospital

Dr. Sarika Rawat, Dr. Avinash Balraj, Dr. Pooja Jain, Dr Roshan Mandloi

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 6, Pages 1110-1114

Background: Convulsions during pregnancy is major cause of maternal and fetal morbidity and mortality. the various causes of seizures during pregnancy include anti-phospholipid syndrome, eclampsia, cerebral vein thrombosis(CVT), thrombotic thrombocytopenic purpura, cerebral infarction, drug and alcohol withdrawal, and hypoglycaemia
Objective: To record and analyze continuous and category variables of antenatal and postnatal patients presenting with seizures.
Materials and Methods: Methodology- the present study conducted in the tertiary care hospital total 270 patient presented with seizure and patient/relative were ready to give consent were included in the study. Study Design: - observational Cross-sectional study.
Result- 65% of the participant were belong to age group of 20-25 years the mean age the mean age of participant with 90 % CI was 23.4667 ±0.7 (±2.98%).64.4% cases were primigravida,and 35.6% were multigravida. morbidity seen in most of cases out of all participant 59.25% were become morbid ,40(29.6%) were remain uncomplicated and 11.11%were died. The mortality rate were observed in our study is 11.11%.Fetal outcome at time of birth the out of all delivery 222 were live birth while 48 were IUD/still birth.
Conclusion- Seizure is serious threat to the maternal and fetal/neonatal health and major contributor of maternal mortality and neonatal mortality.prompt diagnosis and treatment required for it.

A Study of Etiological Profile of New Onset Focal Seizures in Adults

Mahesh A

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 1175-1187

Background: Aim- The aim of this study isto evaluate the etiological profile of new
onset focal seizures in adults.
Materials and Methods: It was a Prospective Observation Cross sectional study. The
ethical committee approval was obtained to carry out the study in the hospital.The
study was carried out during the year from September 2017 to November 2019 for a
period of 26 months. All Adults out- patients and in- patients in the age group of 18 –
70yrs with focal seizures admitted in hospital are evaluated during the period of Study.
Total 50 were included in the study. Detailed history was taken and seizures categorized
according to the classification based on new 2017 International League Against Epilepsy
(ILAE) classification of seizures.
Results: In our study Focal Seizures with impaired awareness are the most common
focal Seizure Type. The age group, most commonly affected is 18 to 30 years.
Granulomatous lesions and Cerebrovascular accidents are the most common cause of
Focal Seizure in younger age group in older age group patients, vascular Pathology is
the most common cause of Focal Seizures. Among Central Nervous System
infections/granulomatous lesions of brain, Nerocysticercosis and tuberculomas are most
common. Incidence in male is more than in female. T.B. Meningitis and Cerebral
Malaria can also present as focal Seizures. CECT & MRI Brain is helpful, when the CT
was inconclusive. There is no significant difference in incidence of Neurocysticercosis
between Vegetarians and Non – Vegetarians. All patients with cerebrovascular
accidents, with focal seizures responded well with AEDs, anti-cerebral edema
measures,& anti platelet drugs in ischemic strokes All patients of Ring enhancing
lesions responded well to treatment with Anti-Epileptic Drugs.
Conclusion: It is mandatory to deal carefully with each case of adult onset seizure with
a tailor-made approach. Identification and awareness about the etiological factors and
seizure type help in better management of these patients. Primary care physicians play
a pivotal role in identifying patients with adult onset seizures and should encourage
these patients to undergo neuroimaging so as to arrive at an appropriate etiological
diagnosis. In the face of recent advances in neuroimaging techniques, the future
prospective management of adult onset seizures appears bright and convincing

ADVANCED NEUROIMAGING TECHNIQUES IN EVALUATING PEDIATRIC EPILEPSY

K. Sree Kala Priyadharsini; Lakshminarayanan Arivarasu

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 376-382

Accurate localization of the seizure onset zone is important for better seizure outcomes and preventing
deficits following epilepsy surgery. Recent advances in neuroimaging techniques have increased our
understanding of the underlying etiology and improved our ability to noninvasively identify the seizure
onset zone. Using epilepsy-specific magnetic resonance imaging (MRI) protocols, structural MRI allows
better detection of the seizure onset zone, particularly when it is interpreted by experienced
neuroradiologists. Ultra-high-field imaging and postprocessing analysis with automated machine learning
algorithms can detect subtle structural abnormalities in MRI-negative patients. Tractography derived from
diffusion tensor imaging can delineate white matter connections associated with epilepsy or eloquent
function, thus, preventing deficits after epilepsy surgery. Arterial spin-labeling perfusion MRI,
simultaneous electroencephalography (EEG)-functional MRI (fMRI), and magnetoencephalography
(MEG) are noninvasive imaging modalities that can be used to localize the epileptogenic foci and assist in
planning epilepsy surgery with positron emission tomography, ictal single-photon emission computed
tomography, and intracranial EEG monitoring. These advanced structural and functional imaging
modalities can be combined with postprocessing methods to better understand the epileptic network and
obtain valuable clinical information for predicting long-term outcomes in pediatric epilepsy.