Online ISSN: 2515-8260

Keywords : Glucose

Mathematical modeling of Glucose, Insulin, -Cell Mass: Homotopy Perturbation Method Approach

K. Saranya; T. Iswarya; V. Mohan; K. E. Sathappan; L. Rajendran

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 3513-3530

kinetics. This paper provides the theoretical and numerical solutions of the
nonlinear differential equation system.The homotopy perturbation method (HPM) is used to find
analytical expressions of the glucose, Insulin, and  -cell mass respectively. A comparison is
also provided between analytical approximation and numerical simulation. A reasonable
agreement between theoretical and simulation results is founded.

Deep Learning Techniques based Non-invasive detection of fasting Blood Glucose Level measurement using Electrochemical Saliva

D. Arul Kumar; Dr.T. Jayanthy

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 1598-1607

In Deep learning methods such as automatic encoder, long-term short-term memory (LSTM) and repetitive neural network (RNN), in mixed group of population, fasting blood glucose level (FBGL) was used to detect the BG level. The Indian population is healthy and sick. The appearance of high FBGL from the electrochemical parameters of human saliva, redox potential, pH, concentration of sodium, and calcium ions was evaluated. Samples were taken from 175 randomly particular persons, half of healthy patients and half of those with diabetes. Models were trained with 70% of all data and tested in the remaining set. In every algorithm, the data points were randomly crossed three times before the model was implemented. The effectiveness of machine learning techniques is presented in terms of the four parameters that are statistically significant, the accuracy, the sensitivity, and the F1 score. The proposed analysis shows that the RNN-based deep learning method yields better results. This deep learning technique to measure blood glucose level non-invasively using electrochemical saliva will helps the society to control the diabetes effectively.

Advanced Glycation End-Products In Diabetes Complications

Anush N; Bineesh C. P.; Jeena Gupta; Pranav Kumar Prabhakar

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 2190-2198

Diabetic complications, such as, retinopathy, nephropathy lead to blindness and end stage renal failure respectively, various neuropathies, and ultimately increased mortality. While the exact mechanisms that lie behind the pathological changes associated with diabetes remain obscure, however, it is widely believed that chronic or intermittent hyperglycemia may alter various metabolic pathways at the tissue level, for instance, increased flux through the polyol and the hexosamine pathways as well as a persistent activation of protein kinase C (PKC). Reducing sugars such as glucose and fructose may react non-enzymatically through their carbonyl groups with free amino groups of proteins (commonly the Ɛ amino group of lysine) to form a Schiff base intermediate which then rearranges to a more stable structure known as Amadori product. The Amadori products generated by the aforementioned Maillard reaction may then undergo further reactions, including dehydration, oxidation and rearrangement resulting in the irreversible formation of heterogeneous advanced glycation end products (AGEs)

Evaluation Of Hba1c As A Valid Tool For Risk Assessment In Ischemic Stroke And TIA

Prof. Dr. Pravati Tripathy, Debjani Nayak, Pratibha Khosla; Sahil Kumar; Anshul Bhateja; Ravneet Kaur; Sukhminder Singh; Gurinder Kaur

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 8, Pages 4773-4777

Background: Stroke is the second leading cause of death in the world in the last two decades. The present study was conducted to evaluate HbA1C as a valid tool for risk assessment in ischemic stroke and TIA.
Materials & Methods: 50 patients who were diagnosed with acute ischemic stroke or TIA, were included. Diagnosis of acute ischemic stroke was made on CT/MRI scan. Estimation of HbA1C was done by photometric test using ion exchange resin. Estimation of blood glucose level was done by glucose oxidase method.
Results: Group I was non- diabetic having 10, group II was pre- diabetic having 8 and group III was diabetic having 22 patients. There were 30 (60%) males and 20 (40%) females. In group A there were 6 males and 4 females, group B had 10 males and 8 females while in group C there were 14 males and 8 females. The sex distribution amongst the three groups did not reveal any statistical difference, and hence all the three groups were comparable.
Conclusion: HbA1C is a novel marker for determining the glycaemic status of a person. In cases of acute ischemic stroke and TIA, HbA1C should be used as a screening tool in determining the previous glycaemic status, prevalence of prediabetes and differentiate it from stress hyperglycaemia.

Correlation Of Hba1c With Lipid Profile In Patients Of Ischemic Stroke Or TIA

Sahil Kumar; Sukhminder Singh; Gurinder Kaur; Ravneet Kaur; Anshul Bhateja; Aprajita Sharma

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 8, Pages 4778-4785

Background: Stroke is the second leading cause of death in the world in the last two decades. The present study was conducted to evaluate correlation of HbA1C with lipid profile in patients of ischemic stroke or TIA.
Materials & Methods: 50 patients of acute ischemic stroke or TIA, were assessed for glycosylated blood glucose and lipid profile level.
Results: There were 10 patients in age group of <50years, 6 patients in age group of 50-60 years, 16 patients in age group 60-70 years, 11 patient in age group of 70-80 years and 7 patients in age group >80 years. The mean FBS (mg/dl) in group I was 96.6, in group II was 116 and in (%) group III was 163, RBS (mg/dl) was 132.1, 157 and 205.6 in group I, II and III respectively, HbA1C (%) was 5.3, 6.15 and 8.43, mean cholesterol level (mg/dl) was 148.6, 151.1 and 220.5, LDL (mg/dl) was 91.6, 97.5 and 154.21, HDL (mg/dl) was 41, 39.8 and 37.6, TG (mg/dl) was 106.9, 192.2 and 175.5 in group I, II and III respectively. The difference was significant (P< 0.05).
Conclusion: HbA1C can be helpful in the management and outcome of patients of ischemic stroke and TIA.


Prabhav Kumar Iyer; Dr. Deepika Rajendaran; Dr. Sarvana Dinesh S.P

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 660-676

Hyperglycemia is a condition in which there is an increase in the blood glucose level of the person. It is one of the most common systemic conditions in middle aged Indians. It is important for a dentist and dental students to be aware of the condition especially while performing invasive procedures as delayed wound healing, coma and hypoglycemic shock are some of the most common complications encountered in some patients. Hence, it is important to know about this condition to prevent any kind of medical emergency on a dental chair. The aim of the study was to assess the knowledge and attitude of dental students while managing hyperglycemic patients indicated for extraction. This study was carried out in a self administered questionnaire format among the students of a dental university. The questionnaire was created on an online platform called “Survey Planet” and was filled by 100 students. The questionnaire consisted of the major aspects of knowledge on hyperglycemia and how students will manage the patient before performing the extraction procedure on them. Based on the tabulated results, it was seen that dental students have greater knowledge towards dealing with hyperglycemic patients indicated for extraction. 64% said that they can perform extraction on a hyperglycemic patient. 93% said that they would test an elderly patient to check their blood glucose level before the procedure. 72% were aware of the management of hyperglycemia. 45% of the participants said that they would do the treatment only after the patient consulted a physician. 11% said that they would deny the treatment. 82% of the participants said that they would keep the appointment for the extraction in the morning. Thus we can conclude that dental students have good knowledge and attitude toward managing hyperglycemic patients indicated for extraction