Online ISSN: 2515-8260

Keywords : Pathology

Clinico pathological features and outcomes of gist: A five year retrospective data from a tertiary cancer care centre in south India

Naveen Ravel, Teena Rajan, Sathiyamoorthy P.N., Arun Ramanan, Chodavarapu Dheeraj, Meena K, Pothala Vijayalakshmi

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 10728-10732

Background and aims: Gastrointestinal stromal tumours (GISTs) are the most common
mesenchymal neoplasms that arise in the gastrointestinal tract.They constitute about
0.1-3% of all GI tumours. Annual incidence is 1.2 per 105 individuals. Surgery remains
the main stay of treatment. The use of adjuvant TKI Imatinib mesylate for 3 years
reduce the frequency of disease recurrencefollowing complete resection.Five year
survival for all stages combined is upto 83%.Here we present a five year retrospective
data on the clinicopathological features and outcomes of GIST from a tertiary cancer
care centre in south India.
Methods: This retrospective study was conducted in a tertiary cancer care centre in
South India.Medical records of all consecutive patients with biopsy and IHC
(Immunohistochemistry) proven GIST cases from January 2017 to December 2021 were
collected, reviewed and analysed .
Results: 38 cases of biopsy and IHC proven GISTs were analysed. Median age was 54
years. 20 were males and 18 were females .The most common primary site was
stomach(45%) followed by small intestine(39%).Majority of the patients were stage III
at presentation (53%). 26 of cases were metastatic at presentation. Primary surgery was
offered in 55% of the patients.68% of the patients received adjuvant treatment with
Imatinib. 83 % of patients (10/12) who completed 3 years of adjuvant treatment
remained disease free and 82% of all patients (31/38) are alive at the time of analysis.
There was no progression in stage IV GISTs treated with Imatinib. 31% of patients
developed GI toxicity with imatinib. Recurrence was seen in only 4 patients (14%) who
received adjuvant TKI (Tyrosine kinase inhibitors). Common sites of recurrence was
liver (50%) and omental and peritoneal secondaries.(50%).Progression on second line
therapy with Sunitinib was seen only in one case of recurrent GIST.
Conclusion: Adjuvant Imatinib is efficacious and is well tolerated by our
population.83% of the patients who completed adjuvant therapy are disease free at 2
years.5 year survival rate is about 82%.There is no grade 3 or 4 toxicity with Imatinib.


Dr. Sunny Goyal, Dr. Prachi Jain, Dr. Dalip Singh Dhiman, Dr. Rajender Punia, Dr. Deergha Singh, Dr. Fayaz Khan H

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 1, Pages 163-169

Aim: To evaluate efficiencies of magnetic resonance imaging & ultrasonographyprocedures for various pathologies related to female pelvic region.
Materials & Methods: This study was performed on total sixty patients. All patients reported for various clinical issues of pelvic region. Magnetic resonance imaging & ultrasonography procedures were used as diagnostic imaging modality. Scanning outcomes of magnetic resonance imaging & ultrasonography have been categorized as group one and group two respectively. All suggestive findings of both imaging modalities were correlated with clinical diagnosis. Based on these existences of correlations, Results thus obtained was compiled and sent for basic statistical analysis. P value less than 0.05 was considered significant (p< 0.05).   
Results: Among all sixty studied patients, females were 14 in age group of 25-28 years. 13 patients were seen in age range of 33-36 years. P value was reported to be significant for this (0.01). Magnetic resonance imaging confirmed Inborn Anomalies in 3 patients. Uterine Mutilation was confirmed in 16 patients by magnetic resonance imaging. Pathologies related to Adnexa were noted in 28 patients. P value was reported to be significant for this (0.002). Endometrial Malignancies were noted in 2 patients. P value was reported to be significant for this (0.001). Pathologies related to Adnexa were noted in 25 patients by Ultrasonography. P value was reported to be significant for this (0.010).
Conclusion: Magnetic resonance imaging was able to detect and confirm almost all studied pathologies related to female pelvic region. Ultrasonography procedure was unable to detect few of those pathologies. Therefore, magnetic resonance imaging is superior and accurate option for scanning pelvis region.


Bakhtiyar Gafurov; Zamira Babadjanova; Dilrabo Khalimova

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 2521-2525

Abstract: Back pain is a syndrome that can be associated with degenerative-dystrophic
changes in the spine, muscle damage and diseases, damage to the nervous system (the spinal
cord, its roots, and peripheral nerves), pathology of the internal organs of the thoracic and
abdominal cavities, pelvis, and mental disorders. The most common cause of acute back pain
is changes that occur when the muscles, ligaments, or joints of the spine are overloaded


Samyuktha P S; Geetha R V; Jayalakshmi somasundaram

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 697-708

Artificial Intelligence is a progressive, rapidly developing field. It has the potential to ease diagnosis, treatment and care of patients. It is vital that medical professionals are aware about Artificial Intelligence and its scope in health care. Artificial Intelligence has the capability to ease diagnosis and care. The future of medicine is Artificial Intelligence based. A survey was carried to assess the awareness levels about Artificial Intelligence and its scopes in Healthcare. A questionnaire was circulated among medical and healthcare professionals. The total participation for the study was 100. The results were collected and tabulated to be analysed using SPSS windows version 20. There was an overall positive response from the participants. 92% believed that Artificial Intelligence is the future of medicine. Recent advancements have made it imperative that the healthcare workers be aware of Artificial intelligence and its scopes. Artificial Intelligence is reaching the medical field. It is a reality that a certain level of hyperbole seems to have taken over the discussion of Artificial Intelligence in healthcare. On one hand, healthcare industrialists and researchers highlight the need for high quality health data, on the other hand, physicians are still waiting for evidence of the usefulness of these tools and wonder who will be held responsible in case of an injury due to the tool, and the other ethical factors associated with it. It can be concluded that the participants had a moderate level of knowledge about Artificial Intelligence and its scopes, which can be improved.