Online ISSN: 2515-8260

Keywords : Chloroquine


Dr.Arun Kumar; Dr.Monisha S

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 5365-5374

The therapy of COVID-19 has attracted great interest in Chloroquine. The latest focus on these chloroquine applications has contributed to a survey on the effect and possibility of hormonobiphase dose reaction on extremely biologically different models. The examination showed that chloroquin usually induced hormetal effects that impacted many types of cells, including tumour cell lines (e.g. human breasts, colons, colones) and non-tumor cell lines, improved viral reproduction, motility of semen, varied behavioural endpoints, and decreased the risk of convulsions. These diverse and nuanced findings indicate that hormetic dose reactions with different biological models and endpoints are common in chloroquine treatments. These findings impact the nature of the study, including dosage number and distance, and suggest a variety of clinical challenges and opportunities focused on the expected outcome.

Recent Medications Of Hydroxychloriquine; Advances Of Aminoquinoline Drugs In Pandemic Era

Ashish sharma; Surbhi Sharma

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 4714-4721

The infection or contagoiuosness of a novel coronavirus found in China (2019-nCoV) is rapidly spreading and increasing worldwide. Due to the lack of effective treatment options for 2019-nCoV, various strategies are being tested all over the world. In this study, we are presented a medicinal impoertances of Hydroxy Chloroquine in the treatment of 2019-nCoV as it is having pretty much similarities with malaria in terms of primary symptoms. However not only Hydroxy Chloroquine can cure the disease, there is a need of proper vaccine for this particular virus to get control in its spread along with multi drug therapy. The present article is collectively presented a report on recent advancements in the medication application of Hydroxychloroquine

Use Of Chloroquine And Hydroxychloroquine In COVID-19 Patients- A Dilemma

Archana Bhatia; Sandeep K Bains; Ruchika Gupta; Tajinder Bansal; Kuldeep S Sandhu; Jaideepa .

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 6558-6565

The terror of COVID-19 is present universally. The number of cases is on rise. There is always debate about use of chloroquine and hydroxychloroquine as a prophylaxis. Healthcare workers being the front line soldiers need additional protection as compared to general population. This review article highlighted the mechanism of action of both drugs and their role in COVID- 19 patients.


Keerthana. B; Dr.R.Gayatri Devi; Dr.Ganesh Lakshmanan

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 822-831

COVID 19 being the deadliest disease all over the world regarded as the pandemic, the hope of every people is to get an effective medication that can counter it. There is a strong belief that chloroquine may help in controlling the virus. It is taken as an oral preparation. Chloroquine or hydroxychloroquine is a drug class 4- aminoquinoline. Chloroquine is contraindicated in people with heart disease or diabetes. It has a narrow therapeutic index and can cause toxicity easily.A derivative of chloroquine, hydroxychloroquine was synthesised first in 1946. Chloroquine is primarily used to prevent and treat malaria in areas where malaria remains sensitive to its effects. A self-administered questionnaire was prepared consisting of 10 questions and was distributed to a random population through Google docs and we got almost 100 responses. About 63% of the participants are aware of COVID-19 and chloroquine. SPSS software was used to analyse the data for descriptive statistics and chi-square analysis for association with gender. About 50% of the participants' perception is that chloroquine will protect them from COVID-19, and are aware that hydroxychloroquine and other forms of chloroquine are undergoing a clinical trial of COVID-19. If it succeeds it will have a big impact on the current crisis.