Online ISSN: 2515-8260

Keywords : SARS

Immune Modulating Mechanisms Implemented To Control N-Cov Disease

Tahreem Fathima; A.S.Smiline Girija; D. Ezhilarasan

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 2551-2561

The n-CoV is a recent pandemic globally raising serious concerns on its exorbitance in both infection, transmission and mortality rate. It is an infectious disease driven by uncontrolled immune mediated inflammatory disease resulting in cytokine storms and acute respiratory respiratory syndrome. The virus affects the respiratory system and other organ systems and lower respiratory tract. Its initial symptoms include dry cough, nausea, fever, sneezing. In the virus and host interactions, both humoral and cellular immune response seem to play a vital role. Innate immunity is the first line of defence against virus invasion. Adaptive immunity also plays an important part in viral clearance via activated cytotoxic T cells that destroy virus-infected cells and antibody-producing B cells that target virus-specific antigens. With no proper medication to control the covid disease, researchers have implemented various immune mediated mechanisms to curb the viral replication and further establishment of the disease. This review thus highlights on the various immune-modulating mechanism implemented against covid disease with its limitations and challenges.


Surya Sitara; Ganesh Lakshmanan; Gayatri Devi R

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 897-907

COVID-19 is a viral infection associated with pneumonia that originated from Wuhan city in December
2019. In the end of 2019, it began spreading in China. It can spread through air droplets and close
communication with those COVID-19 infected people. There were similar episodes of novel respiratory
viral infection like SARS, MERS etc in the past. The main aim of this study is to determine the
comparative impact of day to day life in SARS, MERS and COVID-19. An online survey with a self
structured questionnaire to analyse the comparative impact of SARS, MERS and COVID-19 pandemic
was carried out. The questionnaire was designed using the online survey platform google forms and the
link was circulated through social networks and with the collected responses a descriptive statistical
analysis was carried out using the “SPSS software 2.0”. It is evident that around 97.7% of participants are
aware about SARS and MERS and nearly 92.2% of participants were aware about the symptoms of SARS,
MERS and COVID-19. Majority of participants were aware of the economic impact, social distancing and
intensity of harm caused by the COVID-19 than other epidemics. SARS, MERS and COVID-19 are dead
full respiratory disorders. This study revealed that the majority of the population were aware about the
difference on impact of these respiratory diseases on day to day life and graded the COVID -19 has the
most impact comparatively.