Online ISSN: 2515-8260

Keywords : Oral lichen planus


A Comparative Analysis of different Treatment Modalities of Oral Lichen Planus

Sonali Roy, Archana Kumari, Praveen Chandra

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 1287-1291

Background:Lichen planus (LP) is a common, chronic inflammatory mucocutaneous
disease of unknown etiology and putative autoimmune pathogenesis. The present study
compared different treatment modalities of oral lichen planus.
Materials & Methods: 78 clinically and histopathological diagnosed cases of oral lichen
planus were divided into 2 groups of 39 each. Group I patients were given 0.1% tacrolimus
cream and group II patients were given 0.05% topical application of clobetasol propionate.
Parameters such as pain on VAS and size of the lesion was recorded at baseline, after 3
weeks and 6 weeks.
Results: The mean size (cm2) in group I was 5.8, 3.4 and 1.6 and in group II was 4.7, 3.2
and 1.2 at baseline, 3 weeks and 6 weeks respectively. A non- significant difference was
observed (P> 0.05). The mean VAS was 2.8, 1.4 and 0.6 in group I and 2.9, 1.8 and 0.8 at
baseline, 3 weeks and 6 weeks in group II respectively. The difference was significant (P<
0.05).
Conclusion: 0.1% tacrolimus reduced size of the lesion and pain score efficiently than
0.5% clobetasol propionate in patients of oral lichen planus.

Curcumin alone and curcumin with prednisone in management Oral Lichen Planuspatients

Dr.Rutika Naik, Dr.Lubna Nazneen,Dr Akshay Dhobley,Dr.Aparna Sharma Thombre,Dr.Ullas Saxena,Dr.Suparna Kosta

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 3784-3788

Background:Oral Lichen Planus is a chronic inflammatory mucocutaneous disease affecting
the oral cavity, skin and nails. The present study compared curcumin alone and curcumin
with prednisone in management of cases of oral lichen planus.
Materials & Methods:The present study was conducted on 68 patients diagnosed clinically and
histologically as oral lichen planus which were divided randomly into 2 groups of 34 each. In
group I patients, Curenext oral gel was prescribed for topical application for 15 minutes, three
times a day. In group II patients, a paste of crushed tablet of prednisone and curenext oral gel
was prescribed for 15 minutes, three times a day. All patients were recalled after 10 days for
1st follow up and 20 days later for 2nd follow up and reticulation, erosion and pain on VAS
were recorded.
Results: The mean reticulation score at baseline in group I was 1.82, in group II was 1.80, on
10th day in group I was 1.60 and in group II was 1.14 and on 20th day in group I was 0.86 and
in group II was 1.42. The difference was significant (P< 0.05). The mean erosion score at
baseline in group I was 2.32, in group II was 2.30, on 10th day in group I was 1.95 and in
group II was 1.45 and on 20th day in group I was 0.82 and in group II was 0.10. The
difference was significant (P< 0.05). The mean VAS score at baseline in group I was 4.10, in
group II was 3.94, on 10th day in group I was 3.24 and in group II was 1.92 and on 20th day in
group I was 1.26 and in group II was 0.06. The difference was significant (P< 0.05).
Conclusion:Authors found that combination of curcumin and prednisone proved to be
effective as compared to curcumin alone in patients of oral lichen planus

PREVALENCE OF EROSIVE LICHEN PLANUS : A RETROSPECTIVE STUDY

T. Santhosh; Jayanth kumar Vadivel; Sankari malaiappan

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 1547-1554

Oral Lichen Planus(OLP) is a chronic inflammatory disease which has potential to transform into a malignancy mainly into squamous cell carcinoma. This study was done to evaluate the prevalence of erosive OLP among all OLP cases in a particular ethinic group of people. Materials and method :Data retrieved was from 86000 case sheets from saveetha dental college. The case sheets showed 94 patients with OLP. Most of the patients were in the age group of 50-60 years with a female predominance. 48 patients were erosive OLP variant. A chi square analysis showed erosive OLP had a tendency to occur more in the buccal mucosa(p<0.05). A chi square analysis to compare gender was not significant(p>0.05) This study shows that there is more prevalence of erosive OLP with a female predominance and affecting the buccal mucoa.