Online ISSN: 2515-8260

Keywords : antibiotics


Nimesulide induced flaring in psoriasis

Dr Harmeet Singh, Dr Dheeraj Nair, Dr Nishant Sahu, Dr Syed Tauseeful Haque

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 3840-3842

Background: Nimesulide is a cyclooxygenase (COX) inhibitor with a high degree of selectivity to COX-2. It is a widely used and well tolerated non steroid anti-inflammatory drug that also has analgesic and antipyretic properties. The most frequently reported side effects concern the GI tract. Pruritus and skin rash are the most common cutaneous adverse reactions. Case report: This is a case report of a 58 years old patient who came to ER with develop wheal, multiple joint pain sparing PIP/DIP joint, fever, generalized weakness, decrease oral intake afternimesulide ingestion.He also gave a history of psoriatic arthritis.He was managed with intravenous steroids, antibiotics, antihistaminic & iv analgesics Result:After 2days of medications his general condition improved, joint pain reduced, appetite improved and discharged on oral medicationsConclusion: Drug induced flare is common cutaneous drug reaction, often misdiagnosed. A detailed history taking and physical examination are the key to suspect this condition.

Study of Factors associated with pathological and aerobic microbial colonization of Neonatal Gastrointestinal System – A hospital based Case control study

Faheem Moideen; Baliga Kiran; Harris M M; Davdidson Devasia; Ali Kumble

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 3165-3168

The rate and extent of neonatal gastrointestinal tract colonization depends on various perinatal
and neonatal factors. Colonization of gastrointestinal tract (GIT) after birth could be delayed because of
prematurity, caesarean delivery or total parental nutrition. The ill and preterm neonates in NICU acquire
intestinal flora that differ from that of healthy newborn. Objective: Hence we aim to study the factors associated
with pathological colonization of aerobic microbial flora in neonates and find pattern of pathogenic aerobic
microbial colonization of neonates. Methodology: The study was done on 94 neonates in a tertiary teaching
hospital NICU , 51 cases with pathological colonization ,43 control with normal colonization. Data collected
using Performa, Oral and rectal swabs taken Results: 68 neonates who received antibiotics 46 (90.2%) were
cases 22(51.3%) were controls. Staphylococcus aureus was predominant suggesting influence of maternal
colonization. Cases were more in babies born through LSCS and in babies whose mother had received
antibiotics Conclusion: Of all factors influencing establishment of pathological microbiota in neonatal GIT
which are interdependent , neonatal exposure to antibiotics was the most significant . Emergence of MRSA ,
ESBL are of particular concern as these are a constant threat as source of health care associated infection

To study the changing pattern of bacterial flora and their sensitivity patterns in grade IIIB open fractures of long bones: a prospective study at a Tertiary Centre in North India

Dr.Gursagardeep Singh; Dr. Mandeep Singh; Dr. Anshul Dahuja; Dr.Rashmeet Kaur; Dr.Radhe Shyam; Dr.Haramritpal Kaur; Dr. Shipra

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 3245-3259

Primary goal in management of open fractures is prevention of infection of bone and soft tissue by early debridement, irrigation of wound and administration of broadspectrum antibiotics with stabilization of fractures. The pattern of organisms found in open fractures is important in the selection of antibiotics for prophylaxis and empirical treatment. In this prospective study, 50 consecutive patients of all ages, both the sexes, with open fracture of grade IIIB as per Gustilo- Anderson classification were evaluated for bacterial isolates. Higher rate of infection was found in patients with farm injuries and leg was most common site. The most common gram negative and gram positive bacteria isolated were E.coli and S.aureus respectively (19.5% each). On analysis of the predebridement, post-debridement, and third culture, positive pre-debridement culture showed maximum growth of Gram-positive bacteria. However, majority of these patients were found to have growth of different organism in their post-debridement culture reports.

Treatment Strategies Of Cholera: A Review

Clara Basumatary; Rajinder Kaur; Sukhminderjit Kaur

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 4889-4899

Cholera is a contagious diarrheal disease which spreads through contaminated food and water. It is caused by Gram negative bacterium Vibrio cholerae of the O1 or O139 serogroup. Cholera can potentially spread as epidemic or endemic. If undiagnosed and untreated at the earlier stages, it can result in dehydration and death. Different endeavors are made for the treatment of cholera. Oral rehydration therapy (ORT), use of antimicrobials and antibiotics, probiotics and vaccinations are amongst the various alternative modes of treatment that can be used to treat cholera depending upon the severity of the disease. Also, antibiotics like tetracycline, azithromycin and doxycycline can be used synergistically for the treatment of acute infection and intense dehydration. Researchers have also advocated the use of different vaccines including oral cholera vaccine. In this review, we have provided a brief overview of the cholera disease and its pathogenesis along with different treatment strategies that can be used to treat it or reduce its symptoms.

Phytochemicals as new class of antibiotics to control Multi Drug Resistance

Satish Kumar Sharma; Tejinder Kaur

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 6, Pages 1433-1442

Phytochemicals represent traditional knowledge of compounds effective in symptomatic relief and potential healing properties. The idea has emerged from the fact that natural resources such as neem, turmeric, cloves etc. have been used to cure health problems since a really long time. Even in the current modern world, people have more preference towards natural therapeutics than modern drug formulations. Antibiotics are the drugs which are most easily prescribed unnecessarily to attain extremely rapid symptomatic relief. The practice has led to natural selection of resistant bacterial strains which are spreading at an alarming rate. The world without antibiotics is horrible to contemplate and can cause uncontrollable mortality rate in future due to resistant bacterial infections. The review elaborates importance of phytochemicals as compounds of natural origin, easy production, industrialization scope, broad spectrum antibacterial capabilities to tackle the crisis of antibiotics in the ever growing era of multi drug resistance

Etiopatogenesis And Treatment Of Maxillofacial Inflammatory Processes Using Penicillin Group Antibiotics

Makhmudov Jahongirmirzo; Pulotova Shaxzoda Karimovna

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 3860-3866

Currently, inflammatory processes activate various systems in the body. This article reveals the etiology and pathogenesis of odontogenic inflammatory diseases of the maxillofacial region. Special attention is paid to the aggressive course of the inflammatory process with the defeat of deep cellular spaces, accompanied by pronounced endogenous intoxication. The author analyzes the importance of the use of antibiotics from the group of penicillins in the treatment of inflammatory processes of the maxillofacial region.

CURRENT TRENDS IN ANTIBIOTIC PRESCRIPTION FOR VARIOUS PERIODONTAL FLAP SURGICAL PROCEDURE - A HOSPITAL BASED ANALYSIS

Niveda Rajeshwaran; GurumoorthyKaarthikeyan .; Priyalochana Gajendran

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 1427-1439

The aim of the present study is to assess the current trends in antibiotic prescription for various periodontal flap surgical procedures among periodontists in Chennai. Retrospective data collection was conducted from June 2019 to March 2020 on patients who visited the outpatient department of Periodontics for multitude of flap surgical procedures. The type of flap surgery done and the antibiotic regimen prescribed were recorded. The data was tabulated using excel and SPSS software version 23.0 (Statistical Package For The Social Sciences) was used for descriptive statistics.The distribution of antibiotics after flap surgical procedure among the above mentioned groups were expressed in terms of percentage. Chi square test was done to assess the association between the study variables.Based on this hospital based assessment, it was found that the most commonly prescribed antibiotic was amoxicillin 500mg, followed by a combination of amoxicillin and metronidazole for flap surgical procedures like Open flap debridement, Resective osseous surgery and regenerative osseous surgery. The least preferred antibiotics were azithromycin and doxycycline.There was statistically significant association between gender and type of antibiotic given, with a higher percentage of males receiving a combination of amoxicillin and metronidazole than females. There was no significant difference between the antibiotics prescribed for patients who underwent Resective or regenerative flap surgery. Thus Amoxicillin is the most preferred, cost-effective and less toxic drug which acts against both aerobic and anaerobic microorganisms. However care must be taken in administering antibiotics in order to avoid misuse and overuse of antibiotics.