Online ISSN: 2515-8260

Keywords : WHO Classification


A Clinicopathological Study of Gastric Adenocarcinomas- A Two Year Retrospective Descriptive Study in a Tertiary Care Centre

Ramya Katta, Gaddam Sampoorna, Venkatesh, Kakumanu Nageswara Rao, Annu Mareena George, Ann Mary Varghese

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 6, Pages 867-873

Background: Gastric carcinoma is the third most common cause of cancer related mortality worldwide. The present study is taken up to provide an overview of the spectrum of malignancies, age and sex incidence and risk factor such as tobacco usage, alcohol consumption, dietary intake and blood group analysis of gastric adenocarcinomas in South India.
Martial and Methods: The present study is a two year retrospective study that included all the cases received from   1st August, 2018 to 31st July 2020 in the department of pathology, Guntur Medical College and Government General Hospital, Guntur.
Results: A total of 49 cases were included in the study. The most common age group was sixth decade of life with male preponderance. Gastric outlet obstruction was the most common presenting symptom. Tubular type of gastric adenocarcinoma was the most common histopathological variant.
Conclusion: Regardless of growing understanding of the risk factors, phenotypic and genotypic alterations and diagnostic modalities, Gastric adenocarcinoma still linger to have poor prognosis due to limited treatment options.

A Prospective hospital based observational assessment of patient with ovarian malignancies

Dr. Deepak Thakker, Dr. Shailendra V Mangnale

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 2127-2133

Aim: To analyze the clinical presentation and histopathological types of ovarian malignancies.
Material and methods: A Prospective hospital based observational study was conducted in the Department of Obstetrics and Gynaecology at VIMS, Dahanu for the period of 1.5 years. Total 100 cases of ovarian tumours were included in this study. The tumours were cut and allowed to fix in 10% formalin for 24-48 hours. After formalin fixation, multiple bits were taken for histopathological examination. The blocks were cut at 3-5 microns thickness and stained with Haematoxylin and Eosin. Detailed microscopic examination of the tumour was done.
Results: Out of 100 cases of ovarian tumours, 71 were benign, 6 were tumours of low malignant potential and 23 were malignant. The youngest patient was 12 months and the oldest was 67 years forming a range of 18 months to 67 years. Highest incidence of ovarian tumour was noted in the 40-50years 38cases out of 100 cases accounting for 38%. Highest incidence of benign ovarian tumour was noted in 30-40 years 26 cases out of 71 accounting for 36.62%. Highest incidence of malignant tumour was noted in the 40-50years 12 out of 23 cases accounting for 52.17%. 37% of the patients complained of dull aching lower abdominal pain, 24% complained of abdominal mass and 6% of the patients gave history of menstrual disturbance like menorrhagia. Urinary disturbances were found in 5% patients with tumours. Out of 100 patients 9 patients were not married and all were below twenty years of age. Among married, 83were parous and remaining were 8 nulliparous. Out of 100 cases of ovarian tumors, 29 were associated with appendicitis and 14 were associated with uterovaginal prolapse.
Conclusion: The ovarian tumors manifest a complex and varied spectrum of clinical, morphological and pathological features. Correlating the clinical parameters and categorizing the tumors according to the WHO classification help us in coming to an early diagnosis, management and hence in the prognosis of ovarian tumors.

KNOWLEDGE ABOUT RECENT MODIFICATIONS IN THE CLASSIFICATION OF ODONTOGENIC TUMOUR AMONG ORAL PATHOLOGIST - A QUESTIONNAIRE BASED SURVEY

Aswani. E; Abilasha .; R Gheena. S

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 1016-1031

Classification is the process of grouping similar entities under one category for the case of their comprehension and better handling. The WHO systems of classification is a time - honoured system that has prevailed from decades together and is under constant evolution. Classification of Odontogenic Tumours was formulated by Pieree Paul Broar and has undergone several transformations over 1989 - till 2017. So many entities appear every year in the classification. The study aimed to assess the knowledge , awareness regarding recently revised modification of OT among oral pathologists.A cross sectional, questionnaire based survey study was conducted among 100 oral pathologists around chennai and puducherry population. Ethical clearance was given by the institutional review board and study was conducted over a period of 2 weeks through the questionnaire in google forms and sent in an email link. Questionnaire was divided into various sections based on demographic data, awareness and knowledge along with feedback questions are added in that survey. The statistical analysis done with software 2.1.0 version and microsoft word and excel sheet were used to generate tables and graphs.Of the 100 questionnaires are filled and returned to the response rate of 100%. Majority of the participants fall under the age of 28 - 29 years of about 51% remaining in 24-27 years (34%) with female predominance of 93% (n=93. Majority of the participants were PG residents of about 81%. In that 15% of the participants are not aware about the update version of classification.This survey is first of its kind. From the survey, we conclude that although oral pathologists were aware about OT classification but still most of the PG residents did not have enough knowledge regarding updation in the classification of OT. So, to create awareness regarding odontogenic tumour classification is of utmost importance for oral pathologists as odontogenic tumours are key lesions in diagnosis of oral and jaw swellings