Online ISSN: 2515-8260

Keywords : Phytochemicals

Phytochemicals And Antioxidant Of Methanol Extract Of Gracilaria Salicornia, Halimeda Gracilis, Halimeda Macroloba, And Hypnea Asperi From Tidung Island Coastal Region

Retno Widowati; Sri Handayani; Suprihatin .; Indra Lesmana Rahayu

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 1, Pages 896-907

The research aimed to find out the content of active compound of simplicia and the ability of methanol extract of Gracilaria salicornia, Halimeda gracilis, Halimeda macroloba, and Hypnea asperi as the antioxidant. Phytochemical testing of macro algae simplicia was conducted qualitatively to determine the presence of the active compound, i.e. phenolic, flavonoids, tanin, saponin, steroid, triterpenoid, alkaloid, and hidroquinon. The test method of antioxidant activity is the capture of free radical 1,1-Diphenyl-2-Picrylhidrazyl (DPPH). The active compounds which belongs to macro algae that are tested are flavonoids, steroids, and saponins. The results of examination of antioxidant activity showed the highest percentage of free radical capture of DPPH methanol extract of G. salicornia was 7,228%. The result of univariate ANOVA in antioxidant activity, indicating that there was an effect of concentration on free radical capture of DPPH (p ≤ 0,05) and did not show the interaction between species of macro algae and concentration. The highest percentage of interception DPPH free radical of methanol extracts of each macro algae tested i.e. G. salicornia, H. asperi, H. gracilis, and H. Macroloba respectively

Phytochemicals as new class of antibiotics to control Multi Drug Resistance

Satish Kumar Sharma; Tejinder Kaur

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 6, Pages 1433-1442

Phytochemicals represent traditional knowledge of compounds effective in symptomatic relief and potential healing properties. The idea has emerged from the fact that natural resources such as neem, turmeric, cloves etc. have been used to cure health problems since a really long time. Even in the current modern world, people have more preference towards natural therapeutics than modern drug formulations. Antibiotics are the drugs which are most easily prescribed unnecessarily to attain extremely rapid symptomatic relief. The practice has led to natural selection of resistant bacterial strains which are spreading at an alarming rate. The world without antibiotics is horrible to contemplate and can cause uncontrollable mortality rate in future due to resistant bacterial infections. The review elaborates importance of phytochemicals as compounds of natural origin, easy production, industrialization scope, broad spectrum antibacterial capabilities to tackle the crisis of antibiotics in the ever growing era of multi drug resistance

Antimicrobial Activity of Green Synthesized Silver Nanoparticles Room Sprayer from Arachis hypogaea Root Nodules

Govindaswamy Padmapriya; Alagesan Muthukumaravel; Kamalanathan Ashok; Janarthanan Senthil; Muthu Babu

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 4, Pages 2639-2646

Our research provides an update vision about the recent development in nanodrug by using eco-friendly and cost-effective silver nanoparticles from A. hypogaea root nodules for the first time. We also characterized these silver nanoparticles from various spectroscopic and microscopic methods. Their stability makes the present method a viable alternative to chemical and physical methods. Because of the least specificity of the reaction parameters, this process can be explored for large-scale synthesis of silver nanoparticles. Antimicrobial activity of silver nanoparticles room sprayer showed promising antimicrobial activity against S. aureus, E.coli and A. niger in the 100 ppm concentration and in future this kind of eco-friendly and cost effective silver nanoparticles room sprayer is needed to control many dread full diseases in the present scenario instead of using commercially available room sprayers. The investigation features a productive method to acquire bionanoaerosol that can be used against pathogenic microorganisms, thus contributing to solve this globally serious concern, especially given their being a limited choice of nanoantibiotic treatment.


Pooja Kumari; Ashwani Kumar

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 2544-2551

Millets are the small seeded grains of family Poaceae. They are able to grow on less fertile soils, have low water requirement and short maturity time. They are also nutrient dense in comparison to rice, wheat and maize. Their proteins are free from gluten and hence can be used an alternative to wheat flour for celiac patients. They are rich source of dietary fibre and phytochemicals like phytic acid and ferulic acid. Dietary fibre helps in the growth of probiotic microorganisms and hence millets can be used as a potential prebiotic source. Dietary fibre also reduces the glycaemic index of the food. Phytic acid helps in the reduction of cholesterol and also reduces the cancer. Ferulic acid is an antioxidant and exhibit strong free radical scavenging and anti-inflammatory activity. Nowadays, the millets have been use widely for the development of functional foods.

Phytochemical analysis of α-amylase- inhibiting secondary metabolites of endophyte Penicillium brevicaule alba Thom

Gulyamova T.G.; Nasmetova S.M.; Ruzieva D.M.; Mukhammedov I.I,; Kadyrova G.Kh.; Karimova F. A.

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 829-836

The present work was aimed to identify phytochemicals in methanol extract P. brevicaule alba Thom - CC200, obtained from C. cristata , by qualitative and TLC analysis and evaluation of α-amylase inhibitory activity in vitro. It was determined the presence in the extract of glycosides, terpenoids, and saponins. The partitioning of the extract by TLC showed that inhibition of enzyme activity at 50,3% and 37,6% is associated with two compounds of saponin nature.

Quality Evaluation Of Under-Utilized Crops Of Himachal Pradesh

A. Anand; Y.S. Dhaliwal; R. Verma; Manju .

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 4063-4072

Most of traditional crops have often been used for centuries, but have become increasingly neglected in times as more productive and profitable crops replaced them in farming systems. Almost about half of the humanity’s need regarding calories and proteins is met by three crops, wheat, maize, and rice, but there is an urgent need to promote crop diversification to avoid the vulnerable situations in future.. Under-utilized crops are often rich in nutrients when compared to more popular staple crops. They often contain high levels of protein, vitamins, phytochemicals and they can have a good macronutrient profile of fat, protein and carbohydrates. With regard to health superiority, national under-utilized crops for example pulses can be included as a promising food group. Thence, developing varietalhuman dietary sources e.g., amaranth, buckwheat, ricebean, adzuki bean, chenopodium and many more can play a important role to ensure nutritional security.

Phytochemical Screening And In Vitro Antioxidant Activity Of Enicostemma Hyssopifolium

K. P. Komal; V. M. BerlinGrace; D.David Wilson; Sardar Hussain

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 382-394

Medicinal plants and plant derived products have been part of the health care system since ancient human civilization. Traditional medicine uses plant extracts because of it’s antioxidant activity. In contrast usage of synthetic antioxidants are being restricted due to several limitations. Thus, there is always demand for newer and alternative phytomedicines. The aim of the present study is to analyse phytochemical components and to explore the In vitro antioxidant potential of methanolic extract of Enicostemma hyssopifolium (MEEh). The plant extract was prepared by organic solvents. The MEEh was used for GC/MS analysis and for exploring the prospects of Enicostemma hyssopifolium. The radical scavenging bioassays such as DPPH and ABTS were carried out to study in vitro antioxidant potency. The lipid peroxidation assay was performed to analyse their inhibitory effects and ferric reducing power of the extract was also evaluated. GC/MS analysis revealed that the plant is a rich source of phytochemicals such as 3,5-Dimethoxyacetophenone, Ergost-5-en-3-ol which are known to have antioxidant potency. In the antioxidant assay of MEEh the IC 50 was found to be 655.3>306.6 μg/ml. In lipid peroxidation assay, 33.45% of inhibition was found at 1000 μg/ml. The findings of the study revealed the potential of Enicostemma hyssopifolium as a source for natural antioxidants. It revealed that the plant could be a promising alternative agent in scavenging free radicals and may have ameliorative effect in complications associated with free radical damage.