Online ISSN: 2515-8260

Keywords : Candida albicans

Polyherbal Gel Development And Evaluation For Antifungal Activity

Priyanka B. Parekar , Shivraj S. Shivpuje , Vijay V. Navghare , Manasi M. Savale , Vijaya B. Surwase , Priti S. Mane- Kolpe , Priyanak S. Kale

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 5409-5418

Tridaxprocumbens and Azaridactaindica traditional medicinal plant life which have antifungal hobby in opposition to Candida albicans, a combination of these  plant life have now not been known for its pastime against this fungus. The reason of this research was to formulate topical gel, a combination of Tridaxprocumbens and Azaridactaindicta which has antifungal hobby in opposition to Candida albicans. The antifungal pastime take a look at of T. Procumbens and A. Indica the use of agar well diffusion approach turned into carried out. Thereafter, a topical gel formulation was prepared using Sodium carboxymethyl cellulose as a gelling agent of concentration 1; 1.Five and a couple of%. Test parameters for topical gel includes organoleptic, pH, extrudability, spreadability, diffusion, and stability take a look at.

Comparison of seven different liquid media for germ tube test for candida albicans

Kamlesh Rajpal

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 5599-5604

Infections produced by yeast of the genus Candida are the most frequent fungal
infections, with Candida albicans being the most prevalent isolated species. The quick
identification of this yeast is mostly based on the formation of germ tubes in human or
animal serum. This study details the utilisation of seven different liquid media for germ
tube development at 2, 2.5, 3, and 4 hours. We looked at 193 yeasts for germ tube
formation, including 157 (81.3 percent) C. albicans. At 2 hours, C. albicans germ tube
development was most prevalent in human serum (98%), followed by brain heart
infusion broth (84%), and tryptic soy broth (65.6%).Sensitivity, specificity, positive
predictive value (PPV), and negative predictive value (NPV) for human serum germ
tube formation at 2 h were 98 percent, 100 percent, 100 percent, and 92.3 percent,
respectively. An incubation period of more than 2 hours improves sensitivity but
decreases specificity, as well as the PPV and NPV of the germ tube test in all tested sera
(GTT). In conclusion, with a 2-hour incubation period, human serum was shown to be
the most acceptable medium for GTT.

Insilico Interaction of Bioactive Compounds from Clove againstOral Candida albicans biofilm drug targets

Sindhu priya Kuppusamy; Lakshmi T; Surendar A

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 1, Pages 537-548

Aim: Insilico Interaction of Bioactive Compounds from Clove againstOral Candida albicans biofilm drug targets. Materials and methods: All the 3D models were obtained from PubMed and the final analysis was produced by two systems, mainly chemsketch and GOLD protein-ligand docking. Results : Here in this study we have tried to find the best compatible bio active compound of clove towards the target. Out of 5 Bioactive compounds from clove Eugenol acetate O4,O3 showed the highest docking score having h bond score to be 2.888(O4) , 2.653(O3). Conclusion: In most of the cases the docking the H bond value must be considered must be considered because the hydrogen bonds are stronger than van-der-walls bond and weaker than covalent bond as H bonds have the ability to create a bond or break a bond easily in this study we r trying to read the compatibility between the bioactive compounds and the target compound in this case its Candida albicans biofilm. Further the the research can be extended to wet lab work for further details.


Sharon keziah.V Sharon keziah.V1; Dr. Deepika Rajendran; Dr. R. Pradeep Kumar

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 1237-1246

Denture Stomatitis( DS) is one of the common denture related complications in patients wearing dentures after years of denture use. There have been various studies on its prevalence despite the fact that its exact etiology is still unknown. Removable dentures have served as an important prosthesis in dentistry, whereby it helps in regaining the phonetics and masticatory functions as well as esthetics in edentulous patients. The aim of this study was to determine the prevalence and risk factors that can cause denture stomatitis in denture wearers. This study was designed as a retrospective clinical study. All the patients with removable dentures (Complete dentures , Removable Partial dentures , Cast partial denture ) were taken into account and the data was retrieved. The data was analysed and results were recorded.Out of the 1415 subjects wearing dentures (complete or partial ) , 80 were found to have denture stomatitis in which 57.4% were women and 42.6% were men. The majority of the DS patients were in the age group range of 51-80 years. Temporary partial dentures (50%) were the most prevalent type of prosthesis in patients with denture stomatitis. When the medical history was reviewed most of the patients did not have any underlying systemic diseases(61.1%) did not have any medical condition, (18.5%) were diabetic, (11.1 %) were hypertensive. When all the diabetic patients(2577) were evaluated , 9.32% had denture stomatitis .In the study, it was observed that denture stomatitis was prevalent in elderly patients with slight female predilection. Diabetes was the most prevalent systemic illness associated with denture stomatitis