Online ISSN: 2515-8260

Keywords : Stem Cells


Stem cell management is truly a primary bio-insurance for the well-being of babies- A study on Indian pregnant women

Swati Chaudhary, Dr. Supriti Agrawal

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 3403-3418

Background: In recent years, Non-communicable diseases (NCDs) have been shown
in developed countries to have an increasingly important impact on their health status
worldwide. The NCDs are the world's leading cause of death and a significant threat
to public health in developing countries. Almost 71 per cent of deaths worldwide are
individually responsible for non-communicable diseases including cardiovascular
diseases, stroke, cancer, diabetes and chronic condition. Almost three-fourths patients
with non-communicable diseases have died before the age of 70 and 82% of 16 million
prematurely deaths are in small and average countries are due to NCDs as per the
WHO report 2018. India is undergoing rapid transitions with increase in Noncommunicable
diseases (NCDs), that are resulting into significant rise in morbidity
and mortality in Urban and rural populations.47% of the patients in India are bearing
the treatment cost (Out of Pocket) themselves. Stem cell therapy is becoming the
crucial line of treatment for these diseases. In fact, from last two decades, Stem cells
derived from cord blood were used for treatment of blood disorders, immune systems
and metabolic diseases as an alternative to bone marrow transplants. In 2016, Noncommunicable
diseases (NCDs) control initiative was implemented by the Indian
government to educate about the use of stem cells to treat non-communicable diseases.
Doctors and biotech companies are helping to educate pregnant women to encourage
the use of stem cells so they can decide to store their child's cord blood as needed for
future use. Henceforth, this paper aims for understanding the attitude of Indian
pregnant women for the storage and usage of stem cell that would be a critical bioinsurance
for baby’s well –being

STEM CELLS, TISSUE ENGINEERING AND PERIODONTAL REGENERATION: A REVIEW

Dr Khalid Gufran

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 11, Pages 5980-5987

 In this review we aim to discuss the clinical utility of stem cells in regeneration of periodontal tissue from recent studies. We contemplate the main stem cells used for periodontal regeneration, along with bone marrow-derived mesenchymal stem cells. Furthermore we elaborated about the stem cells derived from dental pulp, periodontal ligament, exfoliated human deciduous teeth, apical papilla along with dental follicle precursor cells. These stem cells in future can be utilized for the tissue regeneration in periodontal treatment

ENAMEL REGENERATION - A REVIEW

Ranjana V; Gifrina Jayaraj; Gayathri R

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 1384-1394

Outermost covering of the teeth is dental enamel. Enamel is the hardest substance and highly mineralized tissue present in the human body which is almost 96%. It is formed by developing enamel organ epithelial cells called ameloblasts. The protein present in the enamel that helps in the mineralization process is Amelogenin. It is revealed that stem cells can be used for whole tooth regeneration and enamel regeneration but the main problem faced in fabricating cell free synthetic enamel is the formation of the complex interprismatic substance. The main aim of this review was to analyze and review on the various methods of enamel regeneration. This review was done based on the articles obtained from various search engines such as PubMed, PubMed central and Google scholar. They were collected with a restriction in time basis from 1997 - 2020. The inclusion criteria were original research papers, review articles, in vitro studied among various conditions and articles that contain pros and cons. Exclusion criteria came into account for retracted articles and articles of other languages. All the articles were selected based on Enamel Regeneration. The level of evidence of the reviewed articles were categorized as per the criteria of the centre for Evidence-Based Medicine, Oxford, UK. Enamel is the hardest mineralized tissue, which can withstand masticatory forces and gives protection to underlying dentin and pulp. Enamel cannot be regenerated since the ameloblast which forms the enamel, gets degenerated. Therefore, it should be preserved, as there is no material found to exactly duplicate it.

TOOTH REGENERATION- A REVIEW

Hemaanhini Tamilmani; Gifrina Jayaraj; Gayathri R

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 1420-1426

Tooth loss is quite common worldwide. For treating a lost tooth, treatments such as dental implants (most common worldwide), fillings (made up of inert dental material), dentures, etc. These techniques can restore all the functions of a normal tooth. But using dental tissues and other dental related materials are still a mystery to the dental world. Pubmed research revealed 117 relevant articles. Out of which a total of ‘33’ systematic reviews and their original citations were included in this review. Tooth regeneration is a very complicated process and needs more depth study on this topic. From many of the researches that were reviewed in this article it was seen that there were many new methods developed but none were approved for applying in real life. Tooth regeneration is a vast topic and requires a lot of knowledge to be understood. This study can be used as reference for future research.

HUMAN DENTAL PULP STEM CELLS AND ITS APPLICATIONS IN DENTISTRY- A REVIEW

Mohamed Thameemul Ansari.K. A; Raghu Nandakumar; A.K. Anjali

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 1834-1838

Stem cells are special human cells that can develop into any cell type of the organism if it's induced and have the ability to renew themselves under suitable conditions. Applications of stem cells exist in manyfields. A Review study is conducted to analyze and investigate dental Pulp stem cells and its application. Human pluripotent stem cells (either human embryonic stem cells or induced pluripotent stem cells) can differentiate into every cell type of the human body with infinite self-rentention capacity. Hence, pluripotent stem cells are an ideal source to generate specialized cell types for cell replacement therapy, e.g. beta cells for diabetics Nevertheless, due to a large number of differentiation steps, current protocols for in vitro cell differentiation are rather complex.. To regulate the cell growth and differentiation, almost 20 signaling proteins and small molecules last for more than four weeks. Not all cells differentiate into the targeted cells but take incorrect differentiation paths during this multistep process.. This can lead to a highly heterogeneous cell population with beta cells that are not fully functional. This paper reviews the recent studies and researches about dental pulp stem cells and their applications in the field of dentistry.