Online ISSN: 2515-8260

Keywords : pruritus

Dermatological manifestations in patients with chronic kidney disease: A cross sectional study

Bindushree R, Priyashree R

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 373-379

Introduction: Chronic kidney disease (CKD) is associated with a complex array of cutaneous
manifestations caused either by the disease or by treatment. Cutaneous manifestations in chronic kidney
disease are polymorphic and diverse. Most patients with severe CKD progress to end stage renal disease
(ESRD) with significant morbidity and mortality. The Aim of our study was to evaluate the prevalence
and pattern of cutaneous disorders among patients with chronic kidney disease.
Materials and Methods: One hundred patients of chronic kidney disease above the age of 18 years with
dermatological manifestation were enrolled in the study. A detailed physical examination and
dermatological examination was done and findings recorded. Relevant investigations including complete
haemogram, diabetic profile, ANA, renal function tests, Liver function tests, electrolytes, viral markers,
serum calcium, phosphorous and PTH (parathormone) levels, KOH mount, culture & sensitivity, woods
lamp examination, biopsy was done if indicated.
Results: In our study we included 100 patients of CKD with cutaneous manifestations. The most
common cause of CKD in our study was found to be diabetic nephropathy which was seen in 47% (n=47)
patients. Pruritus was the most common dermatological manifestation seen in 73% (n=73) of the total
study population followed by xerosis in 68% (n=68). More than 50% of the study population had more
than one dermatological manifestations. Nail and hair changes was seen in 43% and 58% respectively.
Conclusion: Patients with end stage renal disease (ESRD) may present with variety of skin abnormalities
and the most common being pruritus and xerosis as seen in our study. An inter-disciplinary approach
involving dermatologists and nephrologists is essential to improve the quality of life of patients with


Jv’n prof. Dr. M. P. Sharma m.d. (hom.); Jv’n dr. Rakesh sharmam.d. (hom.); Jv’n prof. Dr. Anil kumar vangani m.d. (hom.); Jv’n dr. Ravi jain m.d. (hom.); Jv’n dr. Alka jain m.d. (hom.); Jv’n dr. Gaurav gupta (hom.)

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 1233-1237

Under acute skin conditions there comes various ailments of skin like Eczemas,
Anaphylaxis, Atopy, Herpes Simplex, Photo-dermatitis, Seborrhoeic dermatitis, Miliaria,
Chilblains, DRESS reaction, AGEP reaction, Pompholyx etc. are a spectrum of the acute skin
conditions that affects human skin and manifests as erythema, eruptions, wheals, pustulosis and
often present with flaking or scaling skin or wheals, inflammation and pruritus. Homeopathy is
becoming one of the most popular management option for such conditions,and it is authenticated
via its principles- in Ancient Indian Literature and clinical trials are needed to test the efficacy, in
order to help community, Corporates and Government to create a policy to stoppage of work loss
and to improve the overall quality of living of it’s citizens/employees which will be observe b the
end of this study and further studies will be needed for the confirmation.