Online ISSN: 2515-8260

Keywords : chronic


Prospective Analysis of Burden of Hypersensitivity Pneumonitis at a Tertiary Care Hospital

Madhurmay, Rajendra Kumar Saini

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 1, Pages 653-656

Background: Establishing whether patients are exposed to a ‘known cause’ is a key
element in both the diagnostic assessment and the subsequent management of
hypersensitivity pneumonitis (HP).
Objective: The aim of the study is to determine the burden of hypersensitivity
pneumonitis at a respiratory center.
Methods: 100 patients had been enrolled to the study. Demographic, clinical,
radiological and aetiological data were collected with a random identification code for
each patient in view of maintaining the confidentiality during data collection.
Results: Out of 100 patients, there were 65 females and 35 males. Mean age of the
population was 55.50 years (SD = 10.50) years. 50 patients were less than 65 years of
which 30 were aged between 45 to 60 years while 20 were aged <5 years.
Conclusion: In general, patients with acute disease, if correctly and timely diagnosed
and treated, have a good prognosis, and patients usually improve. By contrast, patients
with subacute/chronic HP (in particular those with bird fancier’s disease) often
progress to irreversible pulmonary fibrosis and may die within a few years after
diagnosis.

Microbiological profile and antibiotic sensitivity pattern of bacteria isolated from patients with chronic bacterial prostatitis

Nashwan MR Ibrahim

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 2, Pages 1781-1789

Chronic bacterial prostatitis is a persistent infection of the prostate characterized by frequent relapses due to incomplete eradication of the causative organisms, with a negative impact on patient’s quality of life. This study aimed to determine the most common bacterial causative agents and their antibiotic sensitivity patterns in patients with chronic bacterial prostatitis in Duhok, Kurdistan, northern Iraq. A standardMeares-Stamey four-glass test was performed for all males presenting with chronic prostatitis symptoms for more than 3 months. Men with high leukocyte counts and bacterial growth inexpressed prostatic secretion (EPS) and post-prostate massage urine (VB3) samples but negative first-voided (VB1) and midstream urine (VB2) samples were included in the study. The Phoenix system (Becton Dickinson) was used for bacterial identification and antimicrobial susceptibility testing.Staphylococcus spp. were the most prevalent microorganisms in patients with chronic prostatitis (60.8%), followed by Escherichia coli and Enterococcus spp. (13.7%).Most patients with chronic prostatitis who were diagnosed with Staphylococcus spp. exhibited high resistance tobenzylpenicillin (75.0%), oxacillin (60.5%), and ampicillin (59.0%). Patients diagnosed with Enterococcus spp. showed high resistance to quinupristin-dalfopristin(20.0%), cefoxitin screen (15.7%), clindamycin (16.9%), tetracycline (16.9%), and rifampicin (17.1%). Among those diagnosed with Streptococcus spp., most had resistance to oxacillin (7.4%), tobramycin (8.0%), erythromycin (8.4%), clindamycin (8.4%), tetracycline (8.4%), and mupirocin (12.1%).The patients with E. coli had resistance to extended-spectrum β-lactamases (ESBL)(45.5%) and cefepime (25.0%). In summary, we found that the most prevalent pathogens from patients with chronic bacterial prostatitis are E. coli, Enterococcus spp., and Staphylococcus aureus. Gram-positive isolates showed the highest resistance to benzylpenicillin, fosfomycin, ampicillin, tetracycline, rifampicin, and mupirocin. Moreover, gram-negative bacteria were most resistant to ESBL, cefepime, and ampicillin-sulbactam. To manage this condition, physicians should take into consideration the development of multi-drug resistance among the pathogenic agents.

RHINOSCLEROMA – A RARE CASE REPORT

Dr. Anup Kediya; Dr. Anil Agrawal; Dr. Aanchal Manchanda; Dr. Sunita Vagha

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 1278-1281


Rhinoscleroma is a rare chronic infection with granuloma formation which is
precipitated due to recurrent chronic sinusitis. Clinically patient presents with mass or
swelling in upper airways most commonly in nose with obstructive features. Though there are
many tests for its diagnostic evaluation, histology still holds the mainstream modality for its
confirmatory diagnosis.